ABSTRACT
Bartter's syndrome (BS) is an inherited renal tubular disorder characterized by hypokalemia, hypochloremic metabolic alkalosis, and hyperaldosteronism with normal blood pressure. A 22-year-old woman was referred at 23 week of gestation. Polyhydramnios was detected and the chloride level of the amniotic fluid was high. The mother was treated with indomethacin from 26 to 31 week of gestation. The newborn was delivered at 34 week of gestation. At 8th day of life, indomethacin was also started for the baby. After three days, a colonic perforation developed. Indomethacin-induced colon perforation is uncommon in antenatal Bartter's syndrome. This patient indicates that administration of indomethacin in both antenatal and/or early postnatal period may be associated with colonic perforation.
Subject(s)
Adult , Amniotic Fluid/chemistry , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Bartter Syndrome/complications , Bartter Syndrome/diagnosis , Bartter Syndrome/drug therapy , Bartter Syndrome/genetics , Colonic Diseases/complications , Colonic Diseases/genetics , Female , Gestational Age , Humans , Indomethacin/adverse effects , Infant, Newborn , Intestinal Perforation/chemically induced , Intestinal Perforation/complications , Intestinal Perforation/genetics , Mutation , Polyhydramnios/drug therapy , Polyhydramnios/genetics , Pregnancy , Pregnancy Complications/geneticsABSTRACT
Introducción. La peritonitis meconial se presenta en el recién nacido de término, siendo compicación rara en el prematuro. Ocurre después de una perforación in utero. Ocasionalmente se sella y no está asociada a obstrucción intestinal. Caso clínico. Se presenta un neonato con peritonitis meconial, sin datos de obstrucción intestinal. El diagnóstico fue un hallazgo por radiografía toracoabdominal, corroborado con ultrasonido abdominal por la presencia de calcificaciones. Conclusiones. Se hace una revisión de la literatura, consideraciones clínicas y tratamiento de la peritonitis meconial