1.
Indian J Physiol Pharmacol
;
1990 Apr; 34(2): 101-4
Article
in English
| IMSEAR
| ID: sea-106551
ABSTRACT
Phosphamidon, a systemic organophosphate insecticide, (1.4 mg/kg - dose 1/4th of LD50 given ip), produced several autonomic, neurological and behavioral effects in mice with peak effects being at 15 min. Similar dose in rats also abolished conditioned avoidance response. Pre-treatment with atropine, iproniazid, alpha-methyl-p-tyrosine, p-chlorophenylalanine or thiosemicarbazide reduce many of these effects. This suggests that phosphamidon toxicity involves the central cholinergic, adrenergic, serotonergic and GABAergic systems in addition to peripheral cholinergic effects.
Subject(s)
Animals , Atropine/pharmacology , Autonomic Nervous System/drug effects , Behavior, Animal/drug effects , Fenclonine/pharmacology , Iproniazid/pharmacology , Lethal Dose 50 , Male , Methyltyrosines/pharmacology , Mice , Nervous System Diseases/chemically induced , Phosphamidon/toxicity , Rats , Rats, Inbred Strains , Semicarbazides/pharmacology , Tyrosine 3-Monooxygenase/antagonists & inhibitors , alpha-Methyltyrosine
2.
Indian J Biochem Biophys
;
1983 Apr; 20(2): 96-9
Article
in English
| IMSEAR
| ID: sea-28316
3.
Indian J Physiol Pharmacol
;
1970 Jul; 14(3): 185-92
Article
in English
| IMSEAR
| ID: sea-106703
Subject(s)
Analgesia , Animals , Avoidance Learning/drug effects , Body Temperature/drug effects , Chlorpromazine/pharmacology , Dextroamphetamine/pharmacology , Drug Interactions , Hypnotics and Sedatives/pharmacology , Iproniazid/pharmacology , Male , Mescaline/pharmacology , Motor Activity/drug effects , Oils, Volatile/pharmacology , Plant Extracts/pharmacology , Plants , Rats , Rectum
4.
Indian J Physiol Pharmacol
;
1967 Jan; 11(1): 33-43
Article
in English
| IMSEAR
| ID: sea-106732
Subject(s)
Amphetamine/pharmacology , Animals , Body Temperature/drug effects , Chlorpromazine/antagonists & inhibitors , Drug Synergism , Humans , Hyperkinesis/chemically induced , Hypothermia, Induced , Iproniazid/pharmacology , Lysergic Acid Diethylamide/pharmacology , Motor Activity/drug effects , Nitriles , Plants, Medicinal , Rats , Saponins/antagonists & inhibitors , Serotonin/metabolism , Serotonin Antagonists
5.
J Indian Med Assoc
;
1966 Feb; 46(4): 197-8
Article
in English
| IMSEAR
| ID: sea-103612
6.
Indian J Physiol Pharmacol
;
1965 Jul; 9(3): 103-10
Article
in English
| IMSEAR
| ID: sea-107415
7.
Indian J Physiol Pharmacol
;
1964 Jul; 8(3): 113-6
Article
in English
| IMSEAR
| ID: sea-108917