ABSTRACT
PURPOSE: To evaluate the effects of isoxsuprine and nicotine on TRAM. METHODS: Forty eight 48 Wistar rats distributed into four Groups (n=12). All rats received medication managed daily for 20 days: saline solution (SA), nicotine solution (NI), isoxsuprine solution (IS) and nicotine solution (NI) + isoxsuprine solution (IS). On day 21st the rats were submitted to the caudally based, right unipedicled TRAM flap and after 48 hours, made the macroscopic evaluation of the surface of the flap, photographic documentation and collection of material for histology. Data from macroscopic evaluation were analyzed by ANOVA and microscopic evaluation by Kruskal-Wallis test, with significance level of 5%. RESULTS: In the macroscopic evaluation of isoxsuprine Group retail presented absolute numbers: final area (p=0.001*) and viable area (p=0.006*) with the highest values; necrosis (p=0.001*) had the lowest value. Microscopic examination revealed no significant findings in the study of TRAM under the action of isoxsuprine and nicotine to the percentage of necrosis in the left and right cranial and caudal regions. CONCLUSIONS: There was significant improvement in viability of TRAM using the isoxsuprine solution alone. No influence using nicotine alone and in association with isoxsuprine. .
Subject(s)
Animals , Female , Isoxsuprine/pharmacology , Myocutaneous Flap , Nicotine/adverse effects , Nicotinic Agonists/adverse effects , Rectus Abdominis/transplantation , Vasodilator Agents/pharmacology , Graft Survival/drug effects , Models, Animal , Myocutaneous Flap/pathology , Necrosis/pathology , Prospective Studies , Rats, Wistar , Reproducibility of Results , Rectus Abdominis/drug effects , Rectus Abdominis/pathology , Smoking/adverse effects , Tissue Survival/drug effectsABSTRACT
Effectiveness of nifedipine in suppressing premature uterine activity was studied on 20 normal pregnant women who received, depending on the frequency of uterine contractions and degree of cervical dilatation, 5-10 mg nifedipine orally 8 hourly till the uterine contractions were abolished followed by 5 mg 12 hourly up to 38 weeks of gestation. Another 20 age, gravida and gestational period matched normal pregnant women received 10 mg isoxsuprine hydrochloride orally 8 hourly till the uterine contractions were abolished, followed by 10 mg 12 hourly up to 38 weeks of gestation. Successful tocolysis was observed in 85% of cases receiving nifedipine in contrast to 40% of women receiving isoxsuprine hydrochloride. The mean time from presentation to delivery and mean birth weight were 21.8 days and 2510 g respectively in isoxsuprine hydrochloride treated cases and 34.2 days and 2750 g respectively in cases treated with nifedipine. In either group there were no serious untoward effects on mother, labour and baby.
Subject(s)
Adult , Female , Humans , Isoxsuprine/pharmacology , Nifedipine/administration & dosage , Obstetric Labor, Premature/drug therapy , Pregnancy , Tocolysis , Uterine Contraction/drug effectsABSTRACT
This experiment was designed to compare qualitatvely the inhibitory effects of salbutamol and isoxsuprine on isolated rat uterus at different stages of pregnancy.Twenty female white albino rats were divided equally into four groups, nonpregnant, first, second and third week pregnant groups. A standard segment of the uterus was suspended in oxygenated organ bath.Myometerial contractility was recorded by isotonic lever The effects of oxytocin, salbutamol and isoxsuprine were studied on those four groups of animals. Salbutamol appears to be more potent inhibitory drug to myometerial contractility compared to isoxsuprine in isolated preparation of the rat uterus. Particularly so during pregnancy and as pregnancy advances approaching term