ABSTRACT
No abstract available.
Subject(s)
Humans , Male , Middle Aged , Bile Ducts, Intrahepatic , Cell Differentiation , Cholangiocarcinoma/pathology , Immunohistochemistry , Keratin-19/metabolism , Liver Neoplasms/pathology , Magnetic Resonance Imaging , Tomography, X-Ray ComputedABSTRACT
No abstract available.
Subject(s)
Aged , Humans , Male , Bile Duct Neoplasms/metabolism , Bile Ducts, Intrahepatic/metabolism , Cholangiocarcinoma/metabolism , Immunohistochemistry , Keratin-19/metabolism , Positron-Emission Tomography , Tomography, X-Ray ComputedABSTRACT
Diffuse follicular variant papillary thyroid carcinoma (DFVPTC) is a rare variant papillary thyroid carcinoma. DFVPTC typically occurs in young females, extensively involves one lobe or both lobes entirely with frequent nodal metastasis and vascular invasion. In contrast to the other subtypes of follicular variant, DFVPTC has biologically aggressive behavior. We present a case of DFVPTC arising in a 69-yr-old male patient. He presented hoarseness for a few months. Following diagnosis of malignancy on aspiration cytology, total thyroidectomy with neck dissection was performed. The tumor involved both lobes of thyroid, encroaching the surrounding structures including tracheal cartilage and esophagus. Multiple lymph node metastasis and vascular invasion were also found. The patient passed away due to the unexplained bleeding of surgical site.
Subject(s)
Aged , Humans , Male , CD56 Antigen/metabolism , Carcinoma, Papillary, Follicular/diagnosis , Galectin 3/metabolism , Immunohistochemistry , Keratin-19/metabolism , Lymph Nodes/pathology , Lymphatic Metastasis , Thyroid Neoplasms/diagnosis , Thyroidectomy , Tomography, X-Ray ComputedABSTRACT
Combined hepatocellular carcinoma and cholangiocarcinoma (combined HCC-CC) is a rare subtype of primary liver cancer. We investigated the histopathologic features of transitional or intermediate areas in 21 combined HCC-CCs and immunophenotypes using different hepatic progenitor cell markers (CK7, CK19, c-kit, NCAM, and EpCAM). Major histologic findings of transitional or intermediate areas of 21 combined HCC-CCs included strands/trabeculae of small, uniform, oval-shaped cells with scant cytoplasm and hyperchromatic nuclei embedded within an abundant stroma, small cells with an antler-like anastomosing pattern, and solid nests of intermediate hepatocyte-like cells surrounded by small cells in periphery, in order of frequency. The intermediate area of one tumor was composed predominantly of spindle cells arranged in short fascicles. Immunophenotype of tumor cells with intermediate morphology suggested a progenitor cell origin for this tumor. Clinical findings of combined HCC-CC showed a closer resemblance with those of HCC than those of CC. In univariate analysis, tumor size, TNM stage, and serum alpha-fetoprotein levels showed a significant association with poor patient survival. Serum alpha-fetoprotein level was an independent prognostic indicator in multivariate analysis. In conclusion, an awareness of the clinicopathologic features, specifically the various morphologic features of intermediate areas in this tumor, is essential for prevention of potential misdiagnosis as another tumor.