ABSTRACT
En el presente trabajo se investigaron las alteraciones ultraestructurales en el glomérulo renal de ovejas con hidatidosis. Utilizando microscopía electrónica de transmisión, fueron examinadas muestras renales de 39 ovejas, 34 de ellas con hidatidosis y 5 sin la parasitosis. Adicionalmente, fue realizado un estudio bioquímico a través de dosaje sérico de creatinina, úrea, proteínas totales y albumina. Las alteraciones ultraestructurales identificadas fueron la presencia de depósitos densos mesangiales, subendoteliales e intramembranosos; proliferación de células mesangiales con áreas de esclerosis segmentaria e interposición de células mesangiales con formación de neo-membrana. Durante el estudio bioquímico se observó un aumento significativo de proteínas totales séricas en el grupo experimental en relación con el de control. El estudio demostró que la glomerulonefritis asociada a hidatidosis en ovinos puede ser clasificada en 4 categorías: lesiones mínimas, glomerulonefritis mesangial, glomerulonefritis segmentaria y focal, y glomerulonefritis membranoproliferativa, siendo predominantemente proliferativa y mesangial
Subject(s)
Animals , Echinococcosis/complications , Glomerulonephritis, Membranoproliferative/etiology , Kidney Glomerulus/ultrastructure , Echinococcosis/blood , Echinococcus/pathogenicity , Kidney Glomerulus/parasitology , Microscopy, Electron , Sheep/parasitologyABSTRACT
In an endemic area for schistosomiasis in the northeast of the state of Minas Gerais in Brazil 516 individuals have been submitted to clinical and laboratory examination, ultrasonography of the abdomen and dopplerecocardiography in order to define the morbidity of schistosomiasis before and after treatment. A high prevalence of schistosomiasis (66.3 per cent) and of severe disease (9.5per cent with palpable spleens) were recorded. Ultrasonography classified liver periportal fibrosis as light (19.4 per cent), moderate (27.6 per cent) and intense (6.8 per cent), and 46.0 per cent presented no periportal fibrosis. Twenty one out of the 53 individuals (39.6 per cent) with palpable spleens did not present liver fibrosis on ultrasound. Periportal lymph nodes were described in 33.8 per cent of the population and anti-KLH antibodies were found in the serum of 40.7 per cent. Urinary alterations compatible with the glomerulopathy of schistosomiasis were observed in 4.5 per cent of the population, and 11.7 per cent of the individuals examined by dopplerecocardiography had pulmonary hypertension. Twelve months after treatment for schistosomiasis the prevalence of the disease dropped from 66.3 per cent to 25.0 per cent. In Queixadinha, a profile of the morbidity of schistosomiasis has just been established.
Subject(s)
Humans , Animals , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Schistosomiasis mansoni/epidemiology , Aged, 80 and over , Brazil/epidemiology , Feces/parasitology , Kidney Glomerulus/parasitology , Hypertension, Pulmonary/epidemiology , Kidney Diseases/parasitology , Morbidity , Schistosoma mansoni/isolation & purification , Schistosomiasis mansoni , Schistosomiasis mansoni/prevention & controlABSTRACT
Estudo retrospectivo de 59 crianças com GNDA Pós-estreptocócica, avaliadas quanto à idade, sexo, etiologia, sintomatologia e dados laboratoriais, no período entre 1985 e 1988 no Instituto de Puericultura Martagäo Gesteira da UFRJ (Departamento de Pediatria da Faculdade de Medicina). Foi analisada possível diminuiçäo do número de casos de GNDA pós-estreptocócica com infecçäo anterior de vias aéreas superiores em nosso meio e muitos casos de GNDA sem proteinúria, relacionado provavelmente a forma mais leve de GNDA