ABSTRACT
Previous studies revealed that selectins play key roles in homing of immune cells to inflamed tissues and lymphatic organs. L-selectins are expressed on immune cells and interact with P and E selectins to homing to the tissues, hence, the polymorphisms within the gene of L-selectins may are associated with alteration in its expression. Thus, the current cross-sectional analytical study has been designed to investigate the polymorphisms within L-selectin gene and their relation with visceral leishmaniasis [VL]. This study was performed on 194 samples during 2004-2012.The PCR-SSP and immunoflorescence techniques were used to evaluate the L-selectins polymorphism and anti-Leishmaniaantibody titration, respectively, in 56, 74 and 64 seropositive VL patients [group 1], seropositive healthy controls [group 2] and seronegative healthy controls [group 3]. The results showed that the genotypes [P=0.711] and alleles [P=0.679] within L-selectins gene [A/C] was not differ between groups. Our results also demonstrated that the genotypes within L-selectins in group 1 [P=0.807] and 2 [P=0.441] were not associated with the titration of anti-leishmania antibody. The results identified that the polymorphisms within L-selectins gene were not associated with VL and it may be concluded that these genotypes and alleles are unable to affect immune responses in VL patients