ABSTRACT
Abstract Objective To compare two different treatments—the use of highly purified anhydrous (HPA) lanolin and expressed breast milk—for women with pain and nipple trauma during the breastfeeding process. Method A total of 180 puerperal women were randomly assigned to 2 groups: one was treated with HPA lanolin and the other with their own expressed breast milk. All of the participants received the same breastfeeding technique instructions and therapeutic care standard. Three assessments were performed: at the time of inclusion in the study (after randomization); after 48 hours; and after 7 days. At each interval, data was collected in relation to pain and trauma. A numerical/verbal category scale was used for the pain variable, and the nipple trauma score for the trauma variable. The results were subjected to statistical analysis using the chi-squared test, the Fisher exact test, the student t-test, and the Kolmogorov-Smirnov test. Generalized estimating equations were calculated using the STATA 12 statistical software package (StataCorp LLC, College Station, TX, USA) and IBM SPSS Statistics for Windows, Version 20.0 (IBM Corp, Armonk, NY, USA). Results There was pain improvement from the second to the third assessment in the group that used HPA lanolin, while the pain remained unchanged between these two periods (p< 0.001) in the breast milk group. In terms of trauma, improvement was identified in its extension and depth from the first to the third assessment, and it was higher in the HPA lanolin group than in the breast milk group (p= 0.025). Conclusion The treatment of pain and nipple trauma with HPA lanolin achieved better results than the one with breast milk, based on a 7-day treatment period.
Resumo Objetivo Comparar dois tratamentos distintos—o uso de lanolina anidra altamente purificada (HPA, na sigla em inglês) e o próprio leite materno—para mulheres com dor e trauma mamilar durante o processo de amamentação. Métodos Participaram do estudo 180 puérperas randomizadas para 2 grupos: um utilizou tratamento com lanolina HPA e o outro o próprio leite materno. Todas receberam a mesma orientação quanto à técnica de amamentação e rigor terapêutico e foram avaliadas em três momentos: na inclusão no estudo (após a randomização), em 48 horas e em 7 dias. Em todos os momentos, foram colhidos dados em relação à dor e ao trauma. Para a variável dor, utilizou-se escala de categoria numérica/nerbal e, para a variável trauma, a pontuação de traumas mamilares. Os testes estatísticos utilizados foram: Qui-quadrado, teste exato de Fisher, t de Student, e Kolmogorov-Smirnov, sendo que os modelos de equações de estimação generalizadas foram calculados por meio dos pacotes STATA 12 (StataCorp LLC, College Station, TX, EUA) e IBM SPSS Statistics for Windows, Versão 20.0 (IBM Corp, Armonk, NY, EUA). Resultados Houve melhora da dor da segunda para a terceira avaliação no grupo que utilizou a lanolina HPA, enquanto que no grupo que usou leite materno a dor permaneceu inalterada entre esses dois momentos (p< 0,001). Quanto ao trauma, foi identificada melhora em sua extensão e profundidade, da primeira para a terceira avaliação, e a melhora foi maior no grupo tratado com lanolina HPA do que no grupo tratado com leite materno (p= 0,025). Conclusão O tratamento da dor e do trauma mamilar com lanolina HPA teve melhor resultado comparado com o leite materno, com base em um período de tratamento de 7 dias.
Subject(s)
Humans , Female , Adolescent , Adult , Young Adult , Pain Management/methods , Lanolin/therapeutic use , Milk, Human , Nipples/injuries , Pain/etiology , Breast Feeding/adverse effects , Middle AgedABSTRACT
Abstract Purpose: To investigate the therapeutic potential of honey, Nigella sativa (N. sativa) and their combination in rat model of excisional wound healing. Methods: A circular excision wound was established in the back region of 50 Wistar rats. Subsequently, they were divided into 5 groups and daily topical administration of lanolin in the control group, honey in the honey group, cold-pressed N. sativa seed oil in the N. sativa groups, mix of 1:1 ratio of honey and N. sativa seed oil in the mix group, and phenytoin cream in the phenytoin group were used. Then, wound surface areas were evaluated using digital camera immediately after the injury and at post excision days 5, 10, 15 and 20. Results: Significant reduction in wound surface area was observed within and between the groups (P < 0.001). In the post excision days 5, 10, 15 and 20 the wound surface areas in the mix group were significantly lower than the other groups followed by the phenytoin, honey, N. sativa, and control groups. Conclusion: The wound healing may be improved and accelerated by using topical solutions of honey, N. sativa seed oil and especially their mixture.
Subject(s)
Animals , Male , Wound Healing/drug effects , Plant Oils/pharmacology , Nigella sativa/chemistry , Honey , Phenytoin/pharmacology , Time Factors , Administration, Cutaneous , Random Allocation , Reproducibility of Results , Treatment Outcome , Rats, Wistar , Drug Combinations , Drug Synergism , Lanolin/pharmacologyABSTRACT
PURPOSE: To compare the efficacy of 3 different eye ointment instillations with eyelid taping and eyelid taping alone to prevent eye complications during surgery under general anesthesia. METHODS: A total of 296 eyes of 148 patients who underwent general anesthesia for at least 60 minutes were randomly assigned to 1 of the following 4 groups: group A, eyelid taping alone; group B, eyelid taping with solcoseryl ointment; group C, eyelid taping with carbomer ointment; group D, eyelid taping with lanolin ointment. Schirmer test, tear film break-up time (TF-BUT), conjunctival hyperemia scale (CHS), National Eye Institute corneal staining scale (NSS), and ocular surface disease index (OSDI) were prospectively evaluated before and after general anesthesia. RESULTS: TF-BUT was significantly increased in the group B compared with the preoperative value (p = 0.035). CHS was significantly decreased in all 3 ointment groups (p < 0.05) after general anesthesia and the degree was significantly higher in groups B and C (p < 0.001). No corneal abrasion developed after general anesthesia. However, corneal erosion developed in 20 eyes of previously healthy subjects; 8 eyes (12.5%) in group A, 0 eye (0%) in group B, 2 eyes (2.5%) in group C, and 10 eyes (13.9%) in group D. The occurrence rates of new lesions were significantly lower in groups B and C (p = 0.035). CONCLUSIONS: Both eyelid taping alone and eyelid taping with eye ointment are effective protection methods against corneal abrasion during operation under general anesthesia. Eye ointment instillation together with eyelid taping shows not only improvement of subjective symptoms but also improvement of objective ocular surface parameters proving to be an effective ocular protection during general anesthesia.
Subject(s)
Humans , Actihaemyl , Anesthesia, General , Eyelids , Hyperemia , Lanolin , Prospective Studies , TearsABSTRACT
PURPOSE: To compare the efficacy of 3 different eye ointment instillations with eyelid taping and eyelid taping alone to prevent eye complications during surgery under general anesthesia. METHODS: A total of 296 eyes of 148 patients who underwent general anesthesia for at least 60 minutes were randomly assigned to 1 of the following 4 groups: group A, eyelid taping alone; group B, eyelid taping with solcoseryl ointment; group C, eyelid taping with carbomer ointment; group D, eyelid taping with lanolin ointment. Schirmer test, tear film break-up time (TF-BUT), conjunctival hyperemia scale (CHS), National Eye Institute corneal staining scale (NSS), and ocular surface disease index (OSDI) were prospectively evaluated before and after general anesthesia. RESULTS: TF-BUT was significantly increased in the group B compared with the preoperative value (p = 0.035). CHS was significantly decreased in all 3 ointment groups (p < 0.05) after general anesthesia and the degree was significantly higher in groups B and C (p < 0.001). No corneal abrasion developed after general anesthesia. However, corneal erosion developed in 20 eyes of previously healthy subjects; 8 eyes (12.5%) in group A, 0 eye (0%) in group B, 2 eyes (2.5%) in group C, and 10 eyes (13.9%) in group D. The occurrence rates of new lesions were significantly lower in groups B and C (p = 0.035). CONCLUSIONS: Both eyelid taping alone and eyelid taping with eye ointment are effective protection methods against corneal abrasion during operation under general anesthesia. Eye ointment instillation together with eyelid taping shows not only improvement of subjective symptoms but also improvement of objective ocular surface parameters proving to be an effective ocular protection during general anesthesia.
Subject(s)
Humans , Actihaemyl , Anesthesia, General , Eyelids , Hyperemia , Lanolin , Prospective Studies , TearsABSTRACT
The side effects of chemotherapy on the lips may cause esthetic and functional impact and increase the risk of infection. HPA Lanolin® is an option for supportive therapy because it has anti-inflammatory, antimicrobial and moisturizing properties. Objective: To evaluate the efficacy of this product in the prevention of lip alterations in a population of patients undergoing chemotherapy. Material and Methods: Patients undergoing chemotherapy (n = 57) were examined and distributed into two groups: study (used HPA Lanolin®) and control (without supportive therapy on the lips). We evaluated the patients two weeks after chemotherapy, registering oral alterations, symptoms of pain, discomfort, limitation of mouth opening and dehydration, classified according to a visual analogue scale. Results: Patients who used HPA Lanolin® had lower dehydration and experienced improvement of lip dryness (p<0.001). The main symptoms were dehydration, discomfort, limitation of mouth opening, pain. The main clinical signs were dry lips, mucositis, cheilitis, hematoma, swelling and cracking. We found no difference concerning the variables of pain, discomfort, and limitation of mouth opening between the study and control group. Conclusions: We suggest that HPA Lanolin® is effective in reducing the symptoms of dehydration and the signs of lip dryness resulting from toxicity of chemotherapy, proving to be an interesting alternative supportive therapy for cancer patients.
Subject(s)
Adolescent , Adult , Female , Humans , Male , Young Adult , Antineoplastic Agents/adverse effects , Cosmetics/therapeutic use , Lanolin/therapeutic use , Lip/drug effects , Dehydration/prevention & control , Mucositis/prevention & control , Neoplasms/drug therapy , Pain Measurement , Prospective Studies , Pain/prevention & control , Statistics, Nonparametric , Time Factors , Treatment OutcomeABSTRACT
OBJECTIVE: To evaluate the effect of anhydrous lanolin-based ointment in the process of healing nipple injuries. METHODS: This is a descriptive experimental study was performed in two Maternity Hospitals in São Paulo. The random sample consisted of 50 puerperium women with nipple injuries, hospitalized in the period of June 2002 to July 2003. Participants were randomly assigned into control and experimental groups, by the means of a draw. Statistical analysis was performed using Qui-square, Student's t test, and ANOVA (á at 5%). RESULTS: The size of the injury in the control group reduced in 0.41 ± 0.11 cm (right breast) and 0.29 ± 0.06 cm (left breast) compared to the experimental group, from the first to the second evaluation (p < 0.001), showing to be statistically significant. CONCLUSION: The lanolin is effective in treating nipple injuries.
OBJETIVO: Avaliar o efeito da pomada a base de lanolina anídrica na cicatrização de lesões mamilares apresentadas por puérperas internadas em duas maternidades do Município de São Paulo. MÉTODOS: Estudo experimental descritivo realizado em duas maternidades do Município de São Paulo. A amostra aleatória foi constituída de 50 puérperas com trauma mamilar internadas no período de junho de 2002 a julho de 2003. A amostra foi composta por meio de sorteio aleatório, distribuída entre os grupos controle e experimental. Utilizou-se testes Qui-quadrado, t de Student e ANOVA (á of 5%). RESULTADOS: Observou-se uma diferença na diminuição do tamanho da lesão mamilar de 0,41 ± 0,11 cm (mama direita) e 0,29 ± 0,06 cm (mama esquerda) nas puérperas do grupo experimental para o grupo controle, da primeira para a segunda avaliação (p < 0,001), mostrando ser estatisticamente significativa. CONCLUSÃO: A lanolina foi favorável no tratamento das lesões mamilares.
OBJETIVO: Evaluar el efecto de la pomada a base de lanolina anhídrica en la cicatrización de lesiones del pezón. MÉTODOS: Estudio experimental descriptivo realizado en dos Maternidades de la ciudad de Sao Paulo. La muestra aleatoria estuvo conformada por 50 puérperas con trauma del pezón internadas en el período de junio del 2002 a julio del 2003. La muestra fue compuesta por medio de sorteo aleatorio y distribuida entre los grupos control y experimental. Se utilizó el Chi Cuadrado, t de Student y ANOVA (á del 5%). RESULTADOS: Se observó una diferencia en la reducción del tamaño de la lesión del pezón de 0.41 que ± 0,11 cm (mama derecha) y 0,29 ± 0.06 cm (mama izquierda) en las puérperas del grupo experimental en relación al grupo control, de la primera a la segunda evaluación (p < 0,001), demostrando ser estadísticamente significativa. CONCLUSIÓN: La lanolina es favorable en el tratamiento de las lesiones del pezón.
Subject(s)
Humans , Female , Breast Feeding/adverse effects , Wound Healing , Pain/prevention & control , Lanolin/therapeutic use , Nipples/injuries , Ointments , Simple Random Sampling , Analysis of Variance , Chi-Square Distribution , Clinical TrialABSTRACT
BACKGROUND AND OBJECTIVES: Many people experience problems with a dry nasal mucous membrane, often without wondering why. The cause of problem is known as rhinitis sicca, senile rhinitis, and atrophic rhinitis, etc. A common form of treatment for patients who have such symptoms has been to begin by rinsing the inside of the nose with saline solution, to drop peanut oil, to apply antibiotic-ointment and moisturizing agents. Lanolin has been know as a safe skin moisturizing agent and used to treat dry nose. The purpose of this study was to evaluate the effect of lanolin on a group of patients seeking treatment for dryness of the nose. MATERIAL AND METHODS: Ninety-three patients experiencing problems with dry nasal mucosa were selected from the out-patient clinic. Fifty-seven patients, average age 36.3 years old, were treated with 1:2 mixture of lanolin and vaseline ointment. Thirty-six patients, average age 32.0 years, were treated with vaseline ointment. Both ointments were applied three times a day for two weeks. The efficacy of treatment was determined with pre and post-treatment six symptoms on a visual analogue scale: nasal obstruction, crust formation, mucosal dryness, respiratory discomfort, sleep disturbance, and general discomfort. RESULTS: For subjects treated with lanolin, the average VAS value for nasal obstruction was 5.84+/-2.28 and it decreased to 2.89+/-1.29, while the corresponding values for subjects treated with vaseline were 4.39+/-1.77 decreasing to 3.11+/- 1.24 (p<0.05). Crust formation of lanolin treated subjects were 5.67+/-2.39 and it decreased to 2.09+/-1.46, while the vaseline treated subjects were 4.83+/-1.99 decreasing to 2.33+/-1.31 (p<0.05). Average total symptom improvement was 65.7% (from 27.95+/-9.30 to 9.86+/-4.58) in lanolin treated group, while it was 44.8% (from 20.9+/-76.59 to 11.64+/-4.18) in vaseline treated group. CONCLUSION: We found that the efficacy of lanolin was statistically signigicantly better than that of vaseline. During the study period, there was no local reactions have been reported, nor have any allergic reactions. The present study underlines the fact that the way to treat nasal mucosal dryness is to use lanolin ointment.
Subject(s)
Humans , Hypersensitivity , Lanolin , Mucous Membrane , Nasal Mucosa , Nasal Obstruction , Nose , Ointments , Outpatients , Petrolatum , Rhinitis , Rhinitis, Atrophic , Skin , Sodium ChlorideABSTRACT
Lanolin is a complex material consisting of a mixture of numerous esters and polyesters of high-moleculer-weight alcohols and fatty acids, Lanolin allergy is important because lanolin is widely used as an emulsifier in topical medicaments and in numerous cosmetic preparations. We report a case of allergic contact dermatitis in a 27-year-old female. An erythematous pruritic rash develgood around the eyelid developed after applying a new eye cream and was aggravated after applying Cambison ophthalmic ointment. Patch testing showed positive reactions to Cambison ophthalmic ointment, 30% wool alcohol, Amerchol L101 and Nivea cream. A use test with 100% Cambison ophthalmic ointment base was positive
Subject(s)
Adult , Female , Humans , Alcohols , Dermatitis, Allergic Contact , Esters , Exanthema , Eyelids , Fatty Acids , Hypersensitivity , Lanolin , Patch Tests , Polyesters , WoolABSTRACT
Neomycin is one of the aminoglycoside antibiotics and not uncommonly causes allergic contact dermatitis. Wool alcohol is one of the most widely used lanolin bases and rarely has been reported to cause allergic contact dermatitis. A 63-year-old male presented with a pruritic, erythematous swelling on the right periorbital area. He had a cataract operation on his right eye 10 days ago and has applied several eye drops and topical antibacterial agents. Patch test with Korean standard antigens and ophthalmic preparations revealed strong positive reactions to neomycin sulfate and the Maxitrol ointment composed of dexamethasone, neomycin sulfate and polymyxin B, and positive reaction to wool alcohol. Neomycin may be the major causative agent to produce allergic contact dermatitis, and wool alcohol also has some relation to it.
Subject(s)
Humans , Male , Middle Aged , Anti-Bacterial Agents , Cataract , Dermatitis, Allergic Contact , Dexamethasone , Lanolin , Neomycin , Ophthalmic Solutions , Patch Tests , Polymyxin B , WoolABSTRACT
The present study was performed to evaluate the comedogenicity of several cosmetic ingredients, vegetable oils, steroid and sulfur. The test materials were applied to one ear canal of rabbits for 6 weekdays for 2 weeks. The results were as follows: l. Among the 14 cosmetic ingredients, no comedogenicity was shown in propylene glycol and petrolatum, mild comedogencity in squalene, acetylated lanolin, polyethylene glycol, cetyl aIcohol and Tween 80. Propylene glycol, sodium lauryl sulfate and oleic acid showed moderate comedogenicity. Severe comedogenicity was observed in myristyl myristate, isopropyl myristate, butyl stearate and myristyl lactate. 2. Moderate to severe comedogenicity was shown in olive oil, sesame oil and corn oil and moderate comedogenicity in sulfur (8%) and betamethasone dipropionate (0.06%) R. Histopathologic grading were paralleled the findings of the naked eye.
Subject(s)
Rabbits , Betamethasone , Corn Oil , Ear Canal , Lactic Acid , Lanolin , Myristic Acid , Olea , Oleic Acid , Petrolatum , Plant Oils , Polyethylene Glycols , Polysorbates , Propylene Glycol , Sesame Oil , Sodium Dodecyl Sulfate , Squalene , Sulfur , Olive OilABSTRACT
A group of chemicals that have proved to be frequent causes of allergic contact dermatitis from applied ingredients of the vehicle. Fisher (1971) testing with a vehicle tray of 15 chemicals in 100 patients with allergic contact dermatitis due to topically administered medications found 30 positive patch test reactions of patients and reported that most important sensitiiing chemicals are Ethylenediamine, Lanolin, Farabens, Phenylmercuric acid, and. propylene glycol monostearate. These chemicals have been recognized as such common sensitizers that they are nonincluded. in the standard patch test series by many countries. From the standpoint of allergenicity of topical preparations including topical medicaments and cosmetics, prevention and diagnostic procedures of dermatitis should be investigated extensively through the patch test studies. But, in our country, there has only a few investigation conceming the dermatitis from vehicle, particularly the medicaments and cosmetics. Therefore, author has tried to establish the vehicle tray fitted to our country according to the basic consideration used with the vehicle patch test tray of Fisher. 100 patients suspected of having allergic contct dermatitis due to topical medication or cosmetics were patch tested with a group of chemicals composed of substances commonly found in vehicles of current topical medications or cosmetics. There were many significant reactions to Ethylenediamine, Paraben, Lanolin, Sodium lauryl sulfate, Polyethylene glycol and Turpentine which play a significant role as solubilzer, antioxidants, emulsifieis, exirpients, preservatives, stabilizers, and surfactants. Author proposed that a group of chemicals should be patch tested on patients of allergic contact dermatitis for the establishmc,nt and development of the hypoallergenic topical medicaments or cosmetics.
Subject(s)
Humans , Antioxidants , Dermatitis , Dermatitis, Allergic Contact , Lanolin , Patch Tests , Polyethylene Glycols , Propylene Glycol , Sodium Dodecyl Sulfate , Surface-Active Agents , TurpentineABSTRACT
Os títulos aglutinantes mais elevados foram verificados após a terceira e quarta inoculações. A função da lanolina é tornar lenta a absorção dos antígenos, favorecendo a formação precoce de anticorpos. É necessário observar um intervalo maior entre a primeira e a segunda inoculação quando se tratar de germes de poder tóxico elevado. É condição essencial para a primeira inoculação empregar pequena quantidade de germes ou germes atenuados. O processo empregado permite imunizar, com germes vivos e virulentos, pequenos animais de laboratório para diferentes finalidades (AU).