ABSTRACT
Las manchas de vino de oporto son un tipo de malformación capilar que afecta del 0,3 al 0,5% de la población. Están presentes desde el nacimiento como máculas o placas eritematosas en la piel o mucosas. Sin tratamiento, las lesiones tienden a oscurecerse con la edad, tornándose rojizas o color púrpura, y pueden desarrollar engrosamiento nodular o un granuloma piógeno asociado. Los tratamientos con láser proporcionan mejoría mediante la destrucción selectiva de la vasculatura. Se han utilizado una variedad de láseres vasculares selectivos, pero el tratamiento de primera elección es el láser de colorante pulsado. Los mejores resultados se obtienen cuando el tratamiento es instaurado tempranamente. (AU)
Port wine stains are a type of vascular malformation that affects 0.3% to 0.5% of the population. They are present from birth as erythematous macules or plaques on the skin or mucous membranes. Without treatment, these lesions tend to darken with age, becoming reddish or purple and may develop nodular thickening or an associated pyogenic granuloma. Laser treatments might provide an improvement by selective destruction of the vasculature. A variety of selective vascular lásers may be employed, with the pulsed dye laser as the gold standard treatment. Better results are obtained when the treatment is established early. (AU)
Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Port-Wine Stain/therapy , Facial Injuries/therapy , Lasers, Dye/therapeutic use , Port-Wine Stain/classification , Port-Wine Stain/diagnosis , Port-Wine Stain/etiology , Port-Wine Stain/genetics , Port-Wine Stain/prevention & control , Port-Wine Stain/psychology , Cooling Agents , Facial Injuries/diagnosis , Facial Injuries/psychology , Lasers, Dye/adverse effectsABSTRACT
Many efforts are made to find new and more effective treatments for psoriasis. Intralesional 5-Fluorouracil [5-FU] +epinephrine is a cheap option which can be administered with long intervals. The effectiveness of Pulse Dye Laser [PDL] on psoriasis has been already assessed. We decided to evaluate the effectiveness of 5-FU+epinephrine and compare it to betamethasone and PDL. A group of 22 patients with chronic stable plaque psoriasis were included. Three plaques on each patient were treated with 5- FU + epinephrine, PDL and betamethasone, respectively. Psoriasis Severity Index [PSI] scoring was applied to assess each plaque before treatment and in weeks 2, 4, 6, 12, and 24. Photos of each plaque were taken before treatment and at each treatment and follow-up session. They were finally compared and scored by a dermatologist. Decline in mean Psoriasis Severity Index [PSI] in week 6 [2 weeks after treatment] and in week 24 [the last follow-up session] was statistically significant as compared to baseline in all groups. [P<0.001] The highest decline in mean PSI score was in the 5-FU + epinephrine group while the lowest belonged to the PDL group [80% vs. 27%].The mean period of remission in the 5-FU+epinephrine group was significantly longer in comparison to the two other groups. [P<0.001] In photographic evaluation, the best response was observed in the 5- FU + epinephrine group. 5-FU + epinephrine is a cheap option which can provide a rapid response and long remission .With respect to limited effectiveness, short remission and high cost; PDL dose not seem to be a preferred choice in the treatment of psoriasis
Subject(s)
Humans , Psoriasis/therapy , Fluorouracil , Epinephrine , Lasers, Dye , Betamethasone , Treatment Outcome , Fluorouracil/adverse effects , Lasers, Dye/adverse effectsABSTRACT
Molluscum contagiosum is a common cutaneous disease that may be difficult to treat when there are multiple lesions; especially in children. This study was conducted to determine the efficacy of pulsed dye laser (585 nm) in the treatment of molluscum contagiosum in 20 children. In the treated group, 70.5% of lesions healed after the first treatment; the remaining 10.6% after the second treatment (2 weeks later). The overall cure rate was significantly different from the control group (p< 0.01). The therapy was also well tolerated. Only mild transient hypopigmentation and erythema were observed. None encountered infectious events. In conclusion, pulsed dye laser is a good alternative treatment for molluscum contagiosum due to high efficacy and mild transient side effects.