[ therapeutic effects of oral administration of garlic extract and tablet on experimentally lead acetate poisoning in mouse]

To study the therapeutic effects of garlic extract and tablet on lead poisoning in mouse. Experimental study. Eighty mature male mice with 22-25g body weight. Mice were divided into 8 groups of 10 mice each. All groups received lead acetate [5mg/kg of bady weight] for 21 weeks and after then treated daily for another 4 weeks as follows: group A1, 500mg/kg fresh garlic; group A2, 250mg/kg fresh garlic; group A3, 125mg/kg fresh garlic; group B1, 1/4 Garlet tablet per kg body weight [Eq. to 500 mg fresh garlic]; group B2, 1/8 Garlet tablet per kg body weight [Eq. to 250 mg fresh garlic]; group B3, 1/16 Garlet tablet per kg body weight [Eq. to 125 mg fresh garlic]; group C, 5mg/kg lead acetate and group D did not received any thing in both the first 4 and the second 4 weeks. These results showed that daily administration of fresh garlic [preferably 250-500 mg/kg] or Garlet tablet [1/4 of one garlet tablet per kg body weight] can have therapeutic effects on mice with chronic lead administration. Result showed that garlic and garlet tablets [in a lower grade] have the ability to reduce the lead residues in soft tissues as well as bone in chronic lead poisoned mouse. So, it can be concluded that garlic can be used for lead poisoning therapy in mouse and probably in human and other animals. Moreover, fresh garlic or garlet tablet in aforementioned dose could be used in areas with lead pollution

Clinical toxicological study on lead exposed painters in Egypt

A study of blood lead concentration and its relation to clinical manifestations in 20 painters working for a period ranged from one to 30 years using lead salts in paints is reported. The mean blood lead concentration was 30.8 +/- 10.6 in the exposed painters while in the control group blood lead concentration was 23.4 +/- 5.9. The clinical examination of painters revealed presence of fatigue, headache, irritability, nervousness, pallor and hypertension. The ECG changes are in the form of arrhythmias, ventricular hypertrophy with axis and position defect. The main objective of the present study was to carry out a pilot survey of blood lead concentration in painters and to assess the effect of the increased blood lead concentration on the general health condition of these painters

Recomendaciones en el manejo de intoxicación por plomo / Recommendations in the management of lead poisoning

Se presentan las recomendaciones en el manejo del niño intoxicado por plomo, que se utilizan en los grandes centros de concentración de intoxicaciones. Se habla de la prueba provocadora que se emplea para conocer la cantidad de plomo que puede ser removido y el tratamiento que se deben utilizar con las diferentes concentraciones de plomo en sangre, así como las recomendaciones en el uso de agentes quelantes

Validade de correçäo de valores de ALA-U através da densidade urinária e da concentraçäo de creatinina / Confirmation of U-ALA results through the urinary density and the creatinine content

A determinaçäo do ácido delta aminolevulínico urinário (ALA-U é um dos Indices Biológicos de Exposiçäo (IBE) mais utilizados no controle biológico da exposiçäo ocupacional ao chumbo. O ALA é geralmente determinado na urina colhida ao final da jornada de trabalho, e as variaçöes decorrentes do fluxo urinário säo corrigidas através da concentraçäo de creatinina ou da densidade urinária . O presente trabalho faz um estudo estatístico de 223 resultados de ALA-U obtidos mno Laboratório de Análises Toxicológicas da Faculdade da Faculdade de Fármacia da UFMG, procurando avaliar a validade dessas correçöes. Os resultados demonstram que näo existe diferença significativa entre os valores näo corrigidos e os corrigidos pela densidade, tornando-se desnecessária a utilizaçäo deste parâmetro como fator de correçäo das variaçöes do fluxo urinário

Otimizaçäo das condiçöes analíticas para a determinaçäo espectrofotométrica de àcido delta-aminolevulínico urinário (ALA-U) / Optimization of the analytical conditions for the spectrophotometric determination of urinary-aminolevulinic acid (U-ALA)

Procurando otimizar as condiçöes analíticas da determinaçäo de ALA-U, pelo método de TOMOKUNI & OGATA (1972)1, foi idealizado o presente trabalho. Apesar de o método analítico ser simples e fácil, algumas de suas etapas podem resultar em erros na concentraçäo de ALA-U. Assim, a possível perda ou contaminaçäo durante a fase de ciclizaçäo e de separaçäo do ALA, o papel do intervalo de tempo entre a formaçäo do produto colorido e a leitura espectro fotométrica e a importância da utilizaçäo do espectrofotômetro de duplo feixe na leitura das absorvância foram testadas e discutidas no presente trabalho

study of convulsions in childhood

This prospective study was performed on 400 children, between the ages of 1 month and 13 years with a history of convulsions, admitted during a 2-year period. There were more males than females, with more children admitted in the winter season than in the summer. The largest group suffered febrile convulsions [77%], followed by afebrile convulsions and epilepsy [11.2%], hypocalcaemia with or without rickets [5.7%], central nervous system infections [4.4%] and lead intoxication [0.8%]. In nearly 40% of the children, the laboratory investigations were normal, while polymorphonuclear leucocytosis [37.5%] was the most common laboratory finding. Central nervous system infections were found in all age groups, and hypocalcaemia and lead intoxication were found to be significant causative factors for convulsions in children under 2 years of age