ABSTRACT
Leiomyosarcoma of urinary bladder (LMS-UB) is a highly malignant mesenchymal tumor, accounting for less than 0.5% of all bladder malignancies, with a predominant clinical presentation of hematuria. Here we report a case of low-grade LMS-UB. A 44-year-old male patient was admitted to the hospital with urodynia for 2 weeks. The patient's pelvis CT showed a mass on the right part of the bladder. For this reason, he was initially diagnosed with bladder cancer. We performed a robot-assisted laparoscopic enucleation of the bladder tumor and low-grade LMS-UB was diagnosed with the histopathological examination. He underwent 5 cycles of adjuvant chemotherapy after surgery. At 19months postoperative follow-up, the patient had no symptoms, recurrence, or distant metastasis. There is no report on the treatment of LMS-UB with minimally invasive enucleation worldwide. This case provides a new comprehensive treatment method of enucleation combined with adjuvant chemotherapy for early low-grade LMS-UB to reduce complications and improve patients' quality of life after surgery.
Subject(s)
Male , Humans , Adult , Urinary Bladder/surgery , Leiomyosarcoma/secondary , Robotics , Quality of Life , Pelvis/pathology , Urinary Bladder Neoplasms/pathology , Laparoscopy/methodsABSTRACT
Abstract Introduction: Leiomyosarcoma is a tumor which is rarely seen in the thyroid gland. The diagnosis may be difficult and the treatment is controversial. Objective: The objective of the study is to review the literature about a rare malignant disease of the thyroid gland which has high mortality. Methods: Two cases of thyroid leiomyosarcoma are presented and the previous 23 cases in the current literature are reviewed. Results: A total of 25 cases of thyroid leiomyosarcoma are reviewed; the most common complaint was rapidly growing anterior neck mass, and ten of the 25 patients had distant metastasis at the initial admission. Fifteen of the 25 patients died with the disease in the first 12 months after the diagnosis. Conclusion: The differential diagnosis of thyroid leiomyosarcoma is important and should be performed with other malignancies of the gland, especially with anaplastic carcinoma. The prognosis is poor and there is no consensus regarding the treatment.
Resumo Introdução: Leiomiossarcoma é um tumor raramente observado na glândula tireoide. O diagnóstico pode ser difícil e o tratamento é controverso. Objetivo: O objetivo do estudo foi revisar a literatura sobre um tumor raro da glândula tireoide que possui alto índice de mortalidade. Método: Dois casos de leiomiossarcoma da tireoide são apresentados, e os 23 casos anteriores relatados na literatura atual foram revisados. Resultados: Um total de 25 casos de leiomiossarcoma da tireoide foi revisado. A queixa mais comum foi o rápido crescimento de um tumor cervical anterior; 10 dos 25 pacientes apresentavam metástases distantes no momento da admissão. Quinze dos 25 pacientes foram a óbito nos primeiros 12 meses após o diagnóstico. Conclusão: O diagnóstico diferencial de leiomiossarcoma da tireoide é importante e deve ser feito com outras doenças malignas da glândula, especialmente carcinoma anaplásico. O prognóstico é ruim e não há consenso em relação ao tratamento.
Subject(s)
Humans , Female , Adult , Aged , Thyroid Neoplasms/diagnosis , Leiomyosarcoma/diagnosis , Thyroid Neoplasms/pathology , Thyroid Neoplasms/therapy , Fatal Outcome , Leiomyosarcoma/pathology , Leiomyosarcoma/secondary , Leiomyosarcoma/therapyABSTRACT
OBJECTIVE: The aim of this study was to investigate outcomes in uterine cancer patients undergoing pulmonary metastasectomy and prognostic factors associated with survival after the procedure. METHODS: A retrospective study was performed in 29 uterine cancer patients who underwent surgical resection of pulmonary metastatic lesions at Samsung Medical Center between June 1995 and December 2011. RESULTS: Histopathology showed carcinoma in 17 patients (58.6%) and sarcoma in 12 patients (41.4%). Of the 29 patients, 17 (58.6%) had less than three pulmonary metastatic lesions. Eight (27.6%) had symptoms related to lung metastasis. The 5-year survival rate after pulmonary metastasectomy for the entire cohort was 48.2%. On univariate and multivariate analysis, the presence of pulmonary symptoms and more than three lesions of metastasis were associated with poor survival after pulmonary metastasectomy. CONCLUSION: Pulmonary metastasectomy for uterine cancer is an acceptable treatment in selected patients. Patients with more than three pulmonary metastatic lesions and pulmonary symptoms related to lung metastasis could expect to have worse prognosis after pulmonary metastasectomy.
Subject(s)
Adult , Aged , Female , Humans , Middle Aged , Adenocarcinoma/secondary , Combined Modality Therapy , Hysterectomy/methods , Leiomyosarcoma/secondary , Lung Neoplasms/secondary , Metastasectomy/methods , Prognosis , Retrospective Studies , Treatment Outcome , Uterine NeoplasmsABSTRACT
We report a 45 years-old woman operated in 2003 for a stage IV uterine leiomyosarcoma with lung metastases. Pulmonary metastases were surgically excised in 2003, 2005 and finally in July, 2006. Since then, the patient is in good conditions. There is evidence that resection of pulmonary metastases of gynecologic cancers, when the primary tumor is controlled, significantly prolongs survival.
Subject(s)
Female , Humans , Middle Aged , Leiomyosarcoma/secondary , Lung Neoplasms/secondary , Uterine Neoplasms/pathology , Lung Neoplasms/surgery , Neoplasm Staging , Reoperation , Tomography, X-Ray ComputedABSTRACT
A case of metastatic leiomyosarcoma of the liver was presented. The clinical, radiological, pathologic and therapeutic aspects are mentioned
Subject(s)
Humans , Female , Aged , Leiomyosarcoma/secondary , Liver Neoplasms/secondary , Biopsy , Cecum/pathology , Liver/pathology , Ileum/pathology , Leiomyosarcoma/pathology , Leiomyosarcoma , Liver Neoplasms/pathology , Liver Neoplasms , Cecal Neoplasms/pathology , Ileal Neoplasms/pathology , Tomography, X-Ray ComputedABSTRACT
La biopsia por aspiración con aguja fina esta actualmente aceptada como una técnica diagnóstica segura y confiable. En los pacientes que se presentan con enfermedad metastática diseminada de origin desconocido puede jugar un papel importante aportando un diagnóstico certero y rápido. Brindando de esta forma la oportundad de iniciar un plan terapéutico rápidamente. Esta técnica usualmente se puede realizar sin necesidad de hospitalizar al paciente con lo cual se logra reducir los costos tanto para el paciente como para el hospital. En los casos en que se llega a un diagnóstico definitivo se logra también evitarle una cirugía innecesaria al paciente. Este artículo presenta varios casos ilustrativos en los que se llegó a un diagnóstico final mediante el uso de la biopsia por aspiración con aguja fina