ABSTRACT
No abstract available.
Subject(s)
Adult , Humans , Male , Middle Aged , Bone Marrow/pathology , DNA Mutational Analysis , Leukemia, Myelomonocytic, Chronic/diagnosis , Leukemia, Neutrophilic, Chronic/diagnosis , Leukocyte Disorders/diagnosis , Mutation , Prognosis , Receptors, Colony-Stimulating Factor/genetics , Recurrence , Stem Cell Transplantation , Transplantation, HomologousABSTRACT
We present the case of a 44 years man who presented to us with persistent leucocytosis. Following relevant investigations, we diagnosed him to have Chronic Neutrophilic Leukaemia (CNL); a rare haematological disorder. Ten months later, he remains non-responsive to standard line of treatment.
Subject(s)
Adult , Allopurinol/therapeutic use , Humans , Hydroxyurea/therapeutic use , Leukemia, Neutrophilic, Chronic/diagnosis , Leukocytosis/diagnosis , Male , Prognosis , Vitamins/therapeutic useABSTRACT
Se describe un caso de leucemia neutrofílica crónica asociada a leucemia de piel, en una paciente de 49 años de edad, sexo femenino, diagnosticada en julio de 2001; con presencia de 43.605/mm3 neutrófilos en sangre periférica y médula ósea hipercelular con serie granulocítica hiperplástica. el estudio histopatológico de la piel reveló infiltrado del 70 porciento de blastos tipo mieloide. Fue tratada con hidroxiurea, siendo favorable la resuesta clínica y laboratorial. el hemograma de diciembre de 2001 presentó 5.656/mm3 neutrófilos.
Subject(s)
Humans , Female , Adult , Skin , Leukemia , Leukemia, Neutrophilic, Chronic/diagnosis , Leukemia, Neutrophilic, Chronic/genetics , Leukemia, Neutrophilic, Chronic/therapyABSTRACT
Chronic neutrophilic leukemia is a rare hematological disorder with hepatosplenomegaly and sustained mature neutrophilic leucocytosis. Increased serum vitamin B12, increased serum urine acid levels and increased leukocyte alkaline phosphatase activity are the associated features in the absence of fever or any other underlying disorder to cause leukemoid reaction. We report one such rare case.