Serum lipid profile abnormalities of patients with chronic liver disease due to hepatitis C virus

Liver disease could be associated with abnormalities in plasma lipids and lipoprotein structure and metabolism. A relationship between chronic hepatitis C virus [HCV] infection and lipid metabolism has recently suggested. Although HCV targets the liver, it has become increasingly evident that HCV can induce diseases of many organs. Is to detect the effect of HCV infection on lipid profile in chronic hepatitis and cirrhotic patients. The study was designed as a case-control study that was carried out on 49 patients with an age ranging from 23 to 56 years of both sexes. They were selected from the outpatient clinic of the National Hepatology and Tropical Medicine Research Institute [NHTMRI] in the period from December 2004 to May 2005. Patients were classified into two groups: Group I: 25 cases with early liver disease. Group II: 24 cases with advanced liver cell failure. Twenty apparently healthy control subjects with matched age and sex were also included in the study. Serum lipid profile assay was done by a dry chemistry technique for both patients and controls. Group I and group II showed a significant decrease in serum cholesterol compared to control group [p <0.05], also, group I showed a highly significant difference in serum cholesterol compared to group II [p <0.001]. Group I showed a significant difference in serum TG and LDL compared to group II [P<0.05], also, group II showed a highly significant decrease in serum LDL compared to control group [p < 0.001]. No significant change was found in serum HDL and serum VLDL between the three studied groups [p>0.05]. Chronic liver disease due to HCV infection shows lipid profile derangement which will be more affected with progression of liver cirrhosis

Lipid abnormalities, atherogenicity and lipid peroxidation in nephrotic syndrome patients

Serum lipid abnormalities are common in nephrotic syndrome. Disturbance in lipid enzymatic activities and lipoprotein catabolism may account for uremic hyperlipidemia. Therefore, serum lipids from 25 patients with nephrotic syndrome and from 12 healthy control subjects were examined. Free cholesterol level demonstrated significant increase while lecithin showed significant decrease, in turn, higher F/L ratio [atherogenic index]. Lipase activities revealed significant decrease, while lipid peroxidation was insignificantly increased. F/L ratio was positively correlated [insignificant] with peroxide value and lipase activity [r = 0.14, 0.16, respectively]. In the control group, F/L was negatively correlated with lipase, but was significantly positive versus peroxide value