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1.
Hist. ciênc. saúde-Manguinhos ; 21(4): 1361-1378, Oct-Dec/2014. tab
Article in Portuguese | LILACS | ID: lil-732521

ABSTRACT

Após algumas décadas de batalha, a geriatria e a gerontologia se tornaram as legítimas ciências do envelhecimento. Hoje surge uma contestação a tal condição. Em sua breve história, a medicina antienvelhecimento se afirmou como prática médica que questiona o modo de se endereçar o envelhecimento biológico. Com isso, toda a medicina é questionada. Aqui, exploramos especialmente como essa controvérsia se estrutura em torno dos fundamentos das ciências do envelhecimento. Há bases para esses questionamentos? Como eles foram tratados por aqueles que os receberam? Tendo em vista uma perspectiva sociotécnica, é interessante pensar que, para geriatras e gerontólogos, a necessária crítica à medicina antienvelhecimento também traz uma importante reflexão sobre o modo como as ciências do envelhecimento vêm tratando seu objeto.


After some decades of struggle, geriatrics and gerontology have become the legitimate sciences of aging. Today, their status is being questioned. In its short history, anti-aging medicine has taken root as a medical practice that questions how to address biological aging. In so doing, all medicine is questioned. Here, we explore in particular how this controversy is structured around the founding principles of the sciences of aging. Is there any basis for these questionings? How have they been treated by those who have received them? Taking a socio-technical viewpoint, it is worth considering that for geriatricians and gerontologists, the need to criticize anti-aging medicine also raises some important reflections about how the sciences of aging address their subject.


Subject(s)
Animals , Male , Rats , Anti-Ulcer Agents/pharmacology , Malonates/pharmacology , Stomach Ulcer/prevention & control , Anti-Inflammatory Agents, Non-Steroidal , Ethanol , Gastric Mucosa/pathology , Indomethacin , Prostaglandins/metabolism , Rats, Wistar , Stomach Ulcer/chemically induced , Stomach Ulcer/pathology , Sucralfate/pharmacology
3.
Salud pública Méx ; 56(5): 502-510, sep.-oct. 2014. ilus, tab
Article in English | LILACS | ID: lil-733323

ABSTRACT

Objective. To estimate the annual cost of the National Cervical Cancer Screening Program (CCSP) of the Mexican Institute of Social Security (IMSS). Materials and methods. This cost analysis examined regional coverage rates reported by IMSS. We estimated the number of cytology, colposcopy, biopsy and pathology evaluations, as well as the diagnostic test and treatment costs for cervical intraepithelial neoplasia grade II and III (CIN 2/3) and cervical cancer. Diagnostic test costs were estimated using a micro-costing technique. Sensitivity analyses were performed. Results. The cost to perform 2.7 million cytology tests was nearly 38 million dollars, which represents 26.1% of the total program cost (145.4 million). False negatives account for nearly 43% of the program costs. Conclusion. The low sensitivity of the cytology test generates high rates of false negatives, which results in high institutional costs from the treatment of undetected cervical cancer cases.


Objetivo. Estimar el costo anual del Programa Nacional de Detección Oportuna de Cáncer Cervical en el Instituto Mexicano del Seguro Social (IMSS). Material y métodos. Este análisis de costos examinó las distintas coberturas por región reportadas por el IMSS. Se estimó el número de citologías, colposcopías, biopsias y evaluaciones de patología y los costos de pruebas de diagnóstico y de tratamientos por neoplasia cervical intraepitelial de grado II y III (NIC 2/3) y cáncer cervical. Los costos de las pruebas de diagnóstico se estimaron utilizando una técnica de microcosteo. Se llevó a cabo un análisis de sensibilidad. Resultados. El costo de realizar 2.7 millones de citologías fue de 38 millones de dólares, lo que representa 26.1% del costo total del programa (145.4 millones). Los falsos negativos corresponden a casi 43% de los costos del programa. Conclusiones. La baja sensibilidad de la citología genera un alto número de falsos negativos que resultan en costos elevados para la institución por el tratamiento de estos casos no detectados.


Subject(s)
Animals , Female , Rats , Collagen/metabolism , Fibronectins/metabolism , Laminin/metabolism , Liver Cirrhosis, Experimental/metabolism , Malonates/pharmacology , Antibody Specificity , Dimethylnitrosamine , Evaluation Studies as Topic , Extracellular Matrix/metabolism , Immunoenzyme Techniques , Liver Cirrhosis, Experimental/chemically induced , Rats, Sprague-Dawley
4.
Indian J Biochem Biophys ; 1984 Oct; 21(5): 340-2
Article in English | IMSEAR | ID: sea-26633
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