ABSTRACT
OBJECTIVES: The purpose of this work was to determine whether the intraperitoneal administration of glibenclamide as a K ATP channel blocker could have an effect on the antinociceptive effects of antidepressants with different mechanisms of action. METHODS: Three antidepressant drugs, amitriptyline as a dual-action, nonselective inhibitor of noradrenaline and a serotonin reuptake inhibitor, fluvoxamine as a selective serotonin reuptake inhibitor and maprotiline as a selective noradrenaline reuptake inhibitor, were selected, and the effect of glibenclamide on their antinociceptive activities was assessed in male Swiss mice (25-30 g) using a formalin test. DISCUSSION: None of the drugs affected acute nociceptive responses during the first phase. Amitriptyline (5, 10 mg/ kg), maprotiline (10, 20 mg/kg) and fluvoxamine (20 and 30 mg/kg) effectively inhibited pain induction caused by the second phase of the formalin test. Glibenclamide (5 mg/kg) alone did not alter licking behaviors based on a comparison with the control group. However, the pretreatment of animals with glibenclamide (10 and 15 mg/kg) partially reversed the antinociceptive effects of fluvoxamine but not those of maprotiline. In addition, the highest dose of glibenclamide (15 mg/kg) partially prevented the analgesic effect of amitriptyline. CONCLUSION: Therefore, it seems that adenosine triphosphate-dependent potassium channels have a major role in the analgesic activity of amitriptyline and fluvoxamine.
Subject(s)
Animals , Male , Mice , Analgesics/therapeutic use , Antidepressive Agents/therapeutic use , Glyburide/pharmacology , Pain Measurement/drug effects , Potassium Channel Blockers/pharmacology , Potassium Channels/drug effects , Analysis of Variance , Amitriptyline/therapeutic use , Drug Interactions , Fluvoxamine/therapeutic use , Models, Animal , Maprotiline/therapeutic use , Pain/chemically induced , Pain/drug therapy , Random AllocationABSTRACT
El autor hace un estudio retrospectivo de múltiples casos de depresión tratados con maprotilina (ludiomil). Utiliza la clasificación nosológica de Paul Kielholz y hace un estudio sobre dicho medicamento
Subject(s)
Maprotiline , Maprotiline/therapeutic use , Antidepressive Agents , Antidepressive Agents/therapeutic use , Depression/therapyABSTRACT
Infusöes venosas de antidepressivos é utilizada como técnica de tratamento de Depressöes resistentes, em regime ambulatorial. Em estudo aberto com 33 pacientes, procura-se verificar a eficácia e tolerância do tratamento com infusöes. Duas substâncias, clomipramina (preferentemente serotoninérgica) e Maprotilina (noradrenérgica), säo utilizadas no estudo. Modificaçäo da técnica usual, com aumento do tempo de perfusäo, e cuidados clínicos, possibilitam a aplicaçäo em regime extra-hospitalar. Os resultados indicam evoluçäo favorável em mais de 80 por cento dos casos, com baixo nível de efeitos colaterais. Seguimento de um ano é considerado.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Ambulatory Care , Antidepressive Agents, Tricyclic/therapeutic use , Clomipramine/therapeutic use , Depressive Disorder/drug therapy , Maprotiline/therapeutic use , Antidepressive Agents, Tricyclic/administration & dosage , Clomipramine/administration & dosage , Infusions, Intravenous , Maprotiline/administration & dosage , Treatment OutcomeSubject(s)
Adult , Middle Aged , Humans , Male , Female , Cerebrovascular Disorders/psychology , Depression/drug therapy , Prospective Studies , Maprotiline/therapeutic useABSTRACT
Os autores apresentam inicialmente uma revisäo bibliográfica do uso de infusäo endovenosa em psicofarmacoterapia, como também as principais teorias neuroquímicas das depressöes de fundamento biológico
Subject(s)
Adolescent , Adult , Middle Aged , Humans , Male , Female , Clomipramine/therapeutic use , Depression/drug therapy , Maprotiline/therapeutic use , Drug Therapy, CombinationABSTRACT
El presente ensayo, consistió en un estudio abierto, no comparativo de los efectos clínicos de 75 mgrs. de Maprotilina, en pacientes con Depresión Neurótica y en Reacciones Depresivas de Adaptación, cuya intensidad no hacía necesaria la hospitalización. El control de los pacientes, se realizó en la Consulta Externa del Servicio de Psiquiatría del Hospital Vargas de Caracas. Los autores evaluaron a los pacientes semanalmente, a partir del inicio del tratamiento. Para cuantificar los cambios ocurridos, se utilizó la Escola de Hamilton para depresión y un protocolo que contiene datos relativos a la evolución clínica, tratamientos previos, exploraciones cardiovasculares y de laboratorio, datos biográficos y escalas de evaluación para el médico y el paciente, que incluye el control de efectos colaterales atribuibles al medicamento. Al final del ensayo, casi las tres cuartas partes de la muestra presentó mejoría marcada en tanto que los restantes lo hicieron levemente. Se presentaron efectos secundarios leves en seis pacientes, que desaparecieron después de la segunda semana de tratamiento