Evaluación farmacológica de Medazepam, tabletas de 10 mg / Pharmacologic evaluation of 10 mg medazepam tablets

Se evaluó el comportamiento, la actividad sedante y la actividad anticonvulsivante en ratones tratados con medazepam, tabletas de 10 mg, en relación con el similar comercial de procedencia italiana. Los estudios realizados demuestran que la actividad exploratoria, el efecto anticonvulsivante, así como la disminución de la agresividad en ratones no difieren al evaluar ambas formulaciones

Epidural and intrathecal ketamine and medazolam in dogs

This experimental work was conducted on 16 apparently healthy notivebreed dogs of varying ages and weights. The animals were divided into four groups each of four dogs. Two groups were used for epidural and intrathecal administration of ketamine, the other two groups for Medazolam. The dose of ketamine and Medazolam were 30 mg and 5 mg respectively. The clinical manifestations were noted and the histopathological examination of the spinal cords and their meninges was carried out after 24 hours of drugs injection. The results revealed good analgesic response and the presence of very mild perivascular lesions in the spinal cords which are reversible in nature