ABSTRACT
The aim of the present work was to study the effect of the crude extract of Curcuma zedoaria on peripheral blood cells and tumor progression in C57Bl/6J mice injected with B16F10 murine melanoma cells. The intraperitoneal therapy showed a significant increase in total white and red blood cell counts, a decrease in peritoneal cell number and tumor volume reduction, whereas the oral administration revealed a noteworthy augmentation only in total leukocyte count. These results contribute to evaluate the importance of alternative treatments that employ phytotherapic compounds against tumor progression and its possible immunomodulation.
Subject(s)
Animals , Curcuma , Immunologic Factors , Melanoma/chemically induced , Mice , PhytotherapyABSTRACT
Two cases of cutaneous malignant melanoma were observed in two Iran-Iraq war victims exposed to chemical warfare [sulfur mustard gas]. In both cases melanoma developed on healed areas of mustard gas exposure after several months. The clinical course was unusually dramatic in both cases. Both cases died of aggressive clinical course. Possible etiologic role of mustard gas in the development of malignant melanoma is discussed
Subject(s)
Humans , Male , Melanoma/chemically induced , Mustard Gas/poisoning , Carcinogens , Chemical WarfareABSTRACT
En un hombre de 80 años de edad que padece del mal de Parkinson, se desarrolla un melanoma malignoen la cara durante la administración de L-Dopa. Aunque exista una relación casual entre el crecimiento del tumor y la administración de la droga, puede ser sospechada tal posibilidad la cual debe ser considerada cuando se use este medicamento. Se realiza una revisión sobre el tema