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Experimental & Molecular Medicine ; : 176-184, 2007.
Article in English | WPRIM | ID: wpr-90615

ABSTRACT

We investigated the co-stimulatory role of a cell-surface protein, CD99. Co-ligation of CD99 and suboptimal CD3 induced T-cell activation to a level comparable to that obtained with optimal CD3 or CD3+CD28. We also noted concomitant enhancement of the earliest T-cell receptor (TCR) signaling events. In addition, co-ligation of CD99 and CD3 led to translocation of TCR complexes into the lipid raft, without concomitant migration of CD99 to the raft, and consequent enhancement of TCR zeta-mediated signal 1. These data demonstrate the unique properties of CD99 co-stimulation that distinguish this molecule from CD28 and other raft-resident co-stimulatory factors.


Subject(s)
Humans , Antigens, CD/immunology , CD3 Complex/immunology , Cell Adhesion Molecules/immunology , Down-Regulation , Jurkat Cells , Lymphocyte Activation/immunology , Membrane Microdomains/immunology , Membrane Proteins/immunology , Phosphorylation , Phosphotyrosine/metabolism , Protein Transport , Receptors, Antigen, T-Cell/immunology , T-Lymphocytes/immunology
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