ABSTRACT
On the admission of massive meprobamate intoxication, the blood level was 460 mg/l [H8]. Initial shock [H8-H12] was treated successfully with dobutamine and volume expansion. When hemodialysis and hemoperfusion were started [H18], the blood meprobamate level was 340 mg/l and at the end of the procedure [H29] was 110 mg/I. The recovery was uneventful. The respective part of different rotes of elimination was: Gastric lavages [l: H8, 2: h26]=66g; hepatic metabolism [H8-H28]=9.2 g [calculated]; hemodialysis [H18-H29]=8.15 g; hemoperfusion [hemo-pur-charcoal][H20- H28]=7.15 g [measured by elution]; diuresis 26 hours =2g. These data emphasized the following facts: Correct amounts of the drug were extracted by hemoperfusion and hemodialysis; gastric lavage remains the less invasive and most productive method for extraction and the role of hepatic metabolism has to be taken into account in the recovery of such patients