Benign multicystic peritoneal mesothelioma: literature review and update

Benign multicystic peritoneal mesothelioma (BMPM) is a rare peritoneal tumor diagnosed predominantly in pre-menopausal women. Associated risk factors include endometriosis and pelvic inflammatory disease in women, and prior abdominal surgery in both genders. To date, the pathogenesis of this disease remains controversial with possible etiologies, including a neoplastic versus a reactive process. Given the risk factors, some authors believe that this disease is secondary to a reactive process. However, because some studies describe cases where there is no prior surgical history or inflammatory milieu present, and because of this entity's predilection for recurrence, some authors believe the origin to be neoplastic. Some genetic and familial associations have also been reported. Malignant transformation is extremely rare, with only two cases reported in the literature, despite the recurrence potential. Like the etiology, the name of this entity is also controversial. Some authors prefer the term "peritoneal inclusion cyst (PCM)" instead of "benign cystic mesothelioma" and argue that the term mesothelioma should only be used when there is evidence of atypia. Most cases of BMPM are discovered incidentally. Others reflect sequela of tumor mass effect. It appears intra-operatively as large, multi-focal, cystic lesions in the peritoneal and pelvic cavity. Diagnosis is achieved through surgical sampling with histopathological examination. Immunobiologically, BMPM exhibits multiple small cystic spaces with flattened lining containing calretinin positive cells without atypical features, mitotic figures, or tissue invasion. Treatment includes cytoreductive surgery. Here we present a case of BMPM in a 60-year-old male - a rare disease in an uncommon patient population.

Mesotelioma benigno como causa de dolor abdominal inespecífico en un paciente con Enfermedad de Crohn / Benign multicystic peritoneal mesothelioma in a patient with Crohn disease

Benign multicystic peritoneal mesothelioma is an uncommon lesion arising from the peritoneal mesothelium. It is asymptomatic or presents with unspecific symptoms. Imaging techniques may reveal it, however the final diagnosis can only be made by histopathology. Surgery is the only effective treatment considering its high recurrence rate. We report a 19 years old male with Crohn’s disease. Due to persistent abdominal pain, an abdominal magnetic resonance imaging was performed, showing a complex cystic mass in the lower abdomen. The patient underwent surgery and the lesion was completely resected. The pathological study reported a benign multicystic peritoneal mesothelioma.

Benign mesothelioma of peritoneum presenting as a pelvic mass

A large solitary multiloculated pelvic cyst in a 40-year-old woman with chronic pelvic pain was diagnosed to be a Multicystic Benign Mesothelioma [MBM] of peritoneum at laparotomy. Operative findings showed dense adhesions between uterus and bladder anteriorly, small intestines and pouch of Douglas posteriorly, a right ovarian cyst cm containing clear serous fluid and two nodular deposits were seen in the pouch of Douglas, small multiple deposits was found over the mesentery of small intestine and parietal peritoneum. Total abdominal hysterectomy with bilateral oophorectomy and infracolic omentectomy was done. During surgery, there was injury to the small intestine hence, resection of 10 inches of small intestine with re-anastomosis was carried out. Postoperative recovery was satisfactory. At 3 years follow-up, patient is symptom-free

first report of abdominal mesothelioma in a ram in Iran

Primary tumours arising from the mesothelial cells lining the peritoneal cavity, mesothelioma, have been recorded in the abdominal cavity of cattle, horses, dogs and cats. Abdominal tumour masses from a five-year-old male kordi sheep were found during routine inspection at the Mashhad abattoir. At gross examination, the tumour consisted of gray-white multiple firm, sessile nodules, approximately 2.60 kg in weight. Histopathological examination revealed numerous thin papillary projections covered by cuboidal cells with large vesicular nuclei and prominent nucleoli and in some areas the neoplastic cells lined cystic spaces. Mitotic figures were few. Based on histopathological findings, the tumour was diagnosed as abdominal mesothelioma

Benign multicystic mesothelioma of peritoneum: a clinico-pathological study of four cases

To study the clinico-pathological findings of benign multicystic mesothelioma, also known as multicystic peritoneal inclusion cyst [MPIC] which is a rare disease of mesothelial origin. the clinical medical records and the pathology reports of four patients diagnosed as having benign multicystic mesothelioma at Bahrain Defence Force Hospital during one year period between 2003-2004 were evaluated. The H and E stained slides along with the special histochemistry stains and immunoperoxidase techniques were applied for confirmation of the diagnosis. all cases in our study occurred in females aged of 28-46 years with the mean 39. Two patients had previous surgery. The chief complaints included abnormal uterine bleeding, abdominal or pelvic pain and dyspareunia. The size of the cysts ranged 2-3.2 cm in diameter. The histology showed multilocular cystic spaces lined by mesothelial cells which were confirmed by application of special stains and immunoperoxidaae techniques. benign muticystic mesothelioma/MPIC should be distinguished from other benign and malignant tumours as it has excellent prognosis if completely excised. Proper utilization of diagnostic facilities is essential for accurate diagnosis