Subject(s)
Humans , Female , Aged, 80 and over , Methotrexate/poisoning , Chemical and Drug Induced Liver Injury/diagnosis , Psoriasis/complications , Skin Diseases/diagnosis , Zygoma/injuries , Alcohol Drinking/adverse effects , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Methotrexate/adverse effects , Methotrexate/blood , Methotrexate/therapeutic use , Drug Interactions , Mucositis/pathology , Renal Insufficiency/complications , Proton Pump Inhibitors/adverse effects , Chemical and Drug Induced Liver Injury/prevention & control , Chemical and Drug Induced Liver Injury/blood , Cognitive Dysfunction , Folic Acid/administration & dosage , Folic Acid/therapeutic use , Levetiracetam/adverse effects , Gastrointestinal Diseases/diagnosis , Genitalia, Female/injuries , Hematologic Diseases/diagnosis , Anti-Bacterial Agents/adverse effectsABSTRACT
Acute intoxication with methotrexate, used as an abortive, has not been described in Chile. We report two female patients, aged 15 and 24 years old, who presented with mucositis, erythrodermia, pancytopenia, and elevation of hepatic enzymes. Plasma methotrexate levels confirmed the clinical diagnosis and both patients were treated with high leucovorin doses and management of associated complications. In one patient, pregnancy continued, giving birth to a newborn with cranial, face and limb malformations. The second patient had a late rescue with leucovorin and was discharged with a persistent sensory motor neuropathy. Considering the severity of complications and that patients may deny its use, when there is reasonable clinical suspicion of methotrexate intoxication, leucovorin treatment should be started