ABSTRACT
No abstract available.
Subject(s)
Aged , Humans , Male , Ampicillin/therapeutic use , Anti-Bacterial Agents/therapeutic use , Antimetabolites, Antineoplastic/therapeutic use , Asian People , Cytarabine/therapeutic use , Drug Therapy, Combination , Idarubicin/therapeutic use , Leukemia, Myeloid, Acute/complications , Moraxella/genetics , Moraxellaceae Infections/diagnosis , RNA, Ribosomal, 16S/chemistry , Republic of Korea , Respiratory Tract Infections/diagnosis , Sequence Analysis, RNA , Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization , Sulbactam/therapeutic useABSTRACT
Moraxella catarrhalis pneumonia, although in the immunocompromised patients is very uncommon for community-acquired pneumonia (CAP). It demonstrates a potential pathogen with high mortality when the presence of heavy numbers of organisms, intracellularly and extracellularly, in the sputum Gram's stained smears confirmed by cultures. In 2007, the authors reported a case of a 28-year-old Thai single male patient with acquired-immunodeficiency syndrome (AIDS) and Moraxella catarrhalis pneumonia who dramatically responded to two weeks of oral Amoxyclav (Amoxycillin trihydrate 500 milligrams + Clavulanic acid (Potassium clavulanate) 125 milligrams) treatment at 625 milligrams every 8 hours and then discharged. The present case report describes clinical and initial chest roentgenographic presentations of Moraxella catarrhalis pneumonia in AIDS patient. The importance of chest roentgenographic pictures, CD4/CD8-T lymphocyte ratio, sputum Gram's stainings, cultures with susceptibility testing in establishing a diagnosis, and protective vaccine are discussed.
Subject(s)
AIDS-Related Opportunistic Infections/diagnosis , Adult , Humans , Male , Moraxella catarrhalis , Moraxellaceae Infections/diagnosis , Pneumonia, Bacterial/diagnosisABSTRACT
This study was performed to investigate polymerase chain reaction-based detection of bacterial DNA in middle ear fluid and assess the correlation between the PCR-positive rate with several factors associated with middle ear effusion. The purpose was to gain a further understanding of bacterial infection as a major cause of otitis media with effusion. Of the 278 specimens of middle ear fluid, 39 (14%) tested positive by ordinary culture. The overall detection rate of bacterial DNA using the PCR method was 36.7% for middle ear effusion, and bacterial DNA detection rates of Hemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis in the middle ear effusion were 29.1%, 4.7% and 10.8%, respectively. The bacterial DNA detection rate was higher in ears with a history of acute otitis media than those without the history. High detection rates were observed in patients younger than 48 months who have had a higher tendency to present with acute otitis media. We concluded that PCR is a more sensitive method for the detection of bacteria in middle ear effusion than ordinary culture, and acute otitis media is a major contributor to the pathogenesis of otitis media with effusion.