ABSTRACT
OBJECTIVE@#To explore the efficacy and safety of Zhuang medicine medicated thread moxibustion (ZMTM) on psoriasis vulgaris.@*METHODS@#A multicenter, randomized, parallel controlled clinical trial was designed. A total of 241 outpatients with psoriasis vulgaris were randomly divided into a control group (120 cases) and a treatment group (121 cases) using a central block randomization from June 2015 to May 2018. The control group was treated with Western medicines alone including pidotimod dispersible tablets, vitamin B compound tablets, and compound cod liver oil-zinc oxide ointment. The treatment group was treated with ZMTM every 2 days combined with Western medicines. The two groups received continuous intervention for 30 days. The primary outcome was Psoriasis Area and Severity Index (PASI), and the secondary outcomes included Itch Rating Scale, Dermatology Quality of Life Index (DLQI), Hamilton Anxiety Rating Scale (HAMA), as well as PASI response rate. Meanwhile, adverse events were evaluated during the whole clinical trial. Follow-up was carried out 30 days after treatment.@*RESULTS@#There were 5 cases of shedding in this trial. In intention-to-treat analysis, 236 cases were included and each group contained 118 cases. On the 30th and 60th days, PASI scores of patients in each group were significantly lower than that at baseline (P<0.01) and the PASI score reduction of the treatment group was greater than that of the control group (P<0.01). Itch Rating Scale, DLQI, and HAMA scale were decreased in both groups after treatment, and the treatment group showed a better therapeutic effect (P<0.01). The response rates of PASI 50 and 75 were significantly higher than those in the control group [81.4% (96/118), 43.2% (51/118) vs. 41.5% (49/118), 11.0% (13/118), respectively, P<0.05]. During follow-up, the improvements in scores of PASI, Itch Rating Scale, DLQI, and HAMA of the treatment group were significantly greater than those of the control group (P<0.01). The response rates of PASI 50 and 75 in the treatment group were significantly higher than those in the control group, respectively (both P<0.05). No obvious adverse reaction was found in either group.@*CONCLUSION@#ZMTM combined with Western medicines showed a better therapeutic effect in the treatment of psoriasis vulgaris without obvious adverse reaction. (Trial Registration No. ChiCTR-IOR-16008159).
Subject(s)
Humans , Moxibustion/adverse effects , Psoriasis/drug therapy , Quality of Life , Severity of Illness Index , Treatment OutcomeABSTRACT
OBJECTIVE@#To observe the clinical effect of moxibustion combined with plucking technique at Jiquan (HT 1) for preventing peripherally inserted central catheter (PICC)-related venous thrombosis in the upper limbs of malignant tumor patients.@*METHODS@#A total of 80 malignant tumor patients undergoing PICC were randomized into an observation group and a control group, 40 cases in each one. In the control group, the routine care for PICC was exerted. In the observation group, besides the routine care, moxibustion combined with plucking technique at Jiquan (HT 1) was added. Mild moxibustion was exerted along the venous distribution of PICC (avoiding the entry site) for 10 to 15 min, and then, the circling moxibustion was applied to Quchi (LI 11), Xuehai (SP 10) and Tianfu (LU 3), 3 to 5 min at each acupoint. Finally, plucking technique was given at Jiquan (HT 1) for 5 to 10 min. This combined therapy was intervened since the 2nd day of PICC placement, once daily, 5 times a week, for 3 weeks totally. The incidence of the PICC-related venous thrombosis in the upper limbs was compared between the two groups on day 42 of placement. On day 2, 7, 14, 21, 28, 35 and 42 of PICC placement, the peak systolic velocity (PSV) and the end-diastolic velocity (EDV) of the subclavicular vein on the placement side were observed separately in the two groups.@*RESULTS@#The incidence of the PICC-related venous thrombosis in the upper limbs in the observation group was lower than that in the control group (2.5% [1/40] vs 17.5% [7/40], P<0.05). From day 7 to 35 of PICC placement, PSV of the subclavicular vein on the placement side was higher than that on the day 2 of PICC placement in the observation group (P<0.05). On day 28 and 42 of PICC placement, PSV of the subclavicular vein on the placement side was lower than that on the day 2 of PICC placement in the control group (P<0.05). In the observation group, EDV of the subclavicular vein on the placement side was higher than that on the day 2 of PICC placement from day 7 to 28 of PICC placement (P<0.05). In the control group, EDV of the subclavicular vein on the placement side from day 28 to 42 of PICC placement was lower than that on the day 2 of PICC placement (P<0.05). From day 7 to 42 of PICC placement, PSV and EDV of the subclavicular vein on the placement side in the observation group were all higher than those in the control group (P<0.01, P<0.05).@*CONCLUSION@#The combined treatment of moxibustion with plucking technique at Jiquan (HT 1) can effectively prevent PICC-related venous thrombosis in the upper limbs and improve venous blood flow velocity in malignant tumor patients.
Subject(s)
Humans , Catheterization, Central Venous/methods , Catheterization, Peripheral/adverse effects , Moxibustion/adverse effects , Neoplasms/complications , Upper Extremity , Venous Thrombosis/etiologyABSTRACT
OBJECTIVE@#To observe the clinical effect of penetrating moxibustion on migraine without aura (MO) patients.@*METHODS@#Totally 60 MO patients from the Acupuncture Clinic of the Third Affiliated Hospital of Henan University of Chinese Medicine were collected from November 2015 to February 2017. All patients were assigned to a treatment group and a control group using a random number table, 30 cases in each group. The treatment group was treated with penetrating moxibustion, and the control group was treated with mild moxibustion, thrice a week for 4 consecutive weeks. The total effective rate, Visual Analogue Scale (VAS) scores, headache intensity, and Migraine Specific Quality of Life Questionnaire (MSQ) scores of patients after treatment were compared between the two groups. The moxibustion sensation and reaction after moxibustion were observed, and the adverse reactions were evaluated. All patients were followed up at 4 and 16 weeks after treatment.@*RESULTS@#The total effective rate of the treatment group was significantly higher than that of the control group (93.33% vs. 80.00%, P0.05).@*CONCLUSIONS@#Penetrating moxibustion can significantly relieve pain and improve quality of life of MO patients. After penetrating moxibustion, flushing and sweating of patients were obvious, and the curative effect was superior to the mild moxibustion.
Subject(s)
Humans , Acupuncture Points , Migraine without Aura/therapy , Moxibustion/adverse effects , Quality of Life , Treatment OutcomeABSTRACT
O objetivo deste trabalho é estudar o efeito da moxabustao nos pontos Shu-Mo correspondentes ao Wei (estômago) e ao Xiaochang (intestino delgado) na motilidade gastrintestinal. Material - Foram utilizadas 68 ratas fêmeas EPM-1/Wistar, com peso variando entre 195 e 230 gramas; substância pastosa composta de carvao em pó (28,57 por cento), goma arábica em pó (28,57 por cento), água filtrada (42,85 por cento) e moxa em bastao. Método - Os animais foram previamente mantidos em jejum por 24 horas, casualizados em 4 grupos, sendo cada grupo, de 17 ratas, submetido à administraçao de 1,5 ml da substância pastosa de carvao, com sedaçao prévia por éter sulfúrico e realizados os seguintes procedimentos: GRUPO-CONTROLE (1): As ratas foram desenvolvidas à gaiola. GRUPO MOXA (II): As ratas foram mantidas sedadas com éter sulfúrico, foram localizados os pontos de acupuntura B-21 (Weishu), B-27 (Xiaochangshu), VC-12 (Zhongwan) e VC-4 (Guanyuan) e realizada a técnica de moxabustao por 5 minutos sob narcose. Ao término da moxabustao, as ratas foram devolvidas à gaiola. GRUPO SHAM (III): localizados os pontos de nao acupuntura (regiao axilar anterior bilateral) e realizada técnica de moxabustao, durante 5 minutos, sob narcose. GRUPO ÉTER (IV): As ratas continuaram sedadas com éter sulfúrico por 5 minutos. Ao término do tempo programado, as ratas foram devolvidas à gaiola. Todos os animais dos 4 grupos foram sacrificados com éter sulfúrico no vigésimo minuto do experimento. Foi realizada a retirada cirúrgica do intestino delgado e clampeamento da porçao distal atingida pelo carvao; foram medidos a distância de progressao do carvao desde o piloro e o comprimento total do intestino delgado. Resultado - A análise de variância por postos de Kruskal-Wallis e o teste de comparaçoes múltiplas revelaram que os grupos CONTROLE e MOXA nao diferiram entre si e apresentaram progressao absoluta do carvao significantemente maior que os grupos SHAM e ÉTER. Em relaçao ao comprimento do intestino delgado, nao se obteve valor significante entre os grupos. A análise de variância por postos de Kruskal-Wallis mostrou, em relaçao à percentagem (progressao do carvao/comprimento do intestino delgado), que os grupos CONTROLE e MOXA nao variaram significantemente e que apresentaram uma percentagem significantemente maior que os valores observados nos grupos SHAM e ÉTER.
Subject(s)
Animals , Female , Rats , Acupuncture Points , Acupuncture , Gastrointestinal Motility , Moxibustion/adverse effects , Statistics, NonparametricABSTRACT
Pasteurella multocida infection in man is rare. This organism was isolated from a calf infection of a 48-year-old woman with degenerative arthritis who had the history of treatments with prednisolone, acupuncture and moxa cauterization. She did not have any animal contact. It was condsidered probable that the organism invaded through the cauterization ulcers. The organism was difficult to identify, because of its superficial resemblance to other organisms. Oxi/Ferm and N/F systems failed to identify the isolate. The organism was susceptible to many antimicrobial agents tested except to amikacin and clindamycin.