Cancer stem cell: A rogue responsible for tumor development and metastasis.

Cancer stem cells are a small population of cells in a tumor. They have the ability to self-renew and maintain the tumor. The most apt and accepted hypothesis for tumor development is Cancer Stem Cells. This review focuses on this concept of cancer stem cells, serving their purpose and leading to the development of tumor. There are many cell biomarkers which have been described for the identification and characterization of cancer stem cells. The most prominent of the cellular markers for the detection of cancer stem cells; CD133, CD44, ALDH-1 along with some others have been discussed in detail in this review.

Sudden death: Following metastasis from carcinoma of breast.

We report a case on sudden death brought to the Department of Forensic Medicine, Gauhati medical college, Assam. Death was due to syncope as a result of cardiac tamponade due to pericardial effusion following metastasis from carcinoma of breast. Death from cardiac tamponade following carcinoma breast is not a usual finding on the autopsy table. These sudden deaths make forensic pathologists aware of the course of natural diseases. Cardiovascular diseases accounts for vast majority of cases and certain neoplasm may also present as sudden death. Malignancy of breast is one of the commonest malignancies in females and often it presents late with metastasis to the underlying organs. The importance of autopsy lies here in the fact that it alleviates the doubts in the minds of the relatives of the deceased and relieves the law of the burden of un-necessary investigations. Moreover, role of pathology in Forensic Medicine in such cases is inevitable in establishing the cause of death.

rare metastasis from Hepatocellular carcinoma

Primary hepatocellular carcinoma is the second most common gastrointestinal cancer [GIT] in the Kingdom Skin metastasis occur mainly in advanced cases. Using Medline Search only 48 cases of skin metastasis from hepatocellular carcinoma have been reported in the world literature in the past 10 years, with no report from Saudi Arabia

Malignancy: etiology and recent contemporary trends in the management of human tumors

Today, not only is cancer a major health problem, but the management and care of cancer patients is often complex. With the development of medical oncology, as a subspecialty of internal medicine, the internist is playing an ever increasing role in the care of cancer patients. The present article depicts an overview of the biology and etiology of neoplasma and summarizes an approach to management of different types of human tumors

Vulvar metastasis from anal canal cancer

É relatado o caso de uma paciente portadora de câncer do canal anal, que desenvolveu uma metástase vulvar isolada ipsilateral a um linfonodo inguinal afetado após tratamento conservador, necessitando posteriormente cirurgia radical em bloco. Frisa-se que esta forma rara de doença assemelha-se inicialmente a uma úlcera radionecrótica

Metástase: um processo de múltiplas fases. III. Metástases para sítios específicos / Metastasis: a multistep process. III. Site-specific tumor metastasis

Na sequencia de artigos que revisam a literatura acerca dos mecanismos de metástases, abordamos agora as teorias que tratam das metástases para sítios específicos. A predileçäo de certas neoplasias por determinados órgäos para o desenvolvimento de metástases como os adenocarcinomas de próstata pela coluna vertebral, é aspecto bastante conhecido pelos médicos em geral. Duas linhas de pensamento tentam explicar esta seletividade: a teoria da semente-solo e a teoria anatômica. Hoje acredita-se que haja uma somátoria destas teorias. O artigo da especial ênfase aos mecanismos celulares que determinam as metástases sítio específicas