ABSTRACT
El neurofibroma raramente aparece como una lesión solitaria, excepto cuando está presente en los huesos maxilares. Por el contrario, múltiples lesiones se observan en la neurofibromatosis de Von Recklinhausen. El neurofibroma central ha sido informado tanto en mandíbula como en maxilar; sin embargo, esta última ubicación es la más común. Presentamos un caso de neurofibroma central de la mandíbula.
Subject(s)
Humans , Female , Mandibular Diseases/surgery , Neurofibroma/surgery , Neurofibroma/diagnosis , Neurofibroma/pathology , Histological Techniques , Magnetic Resonance Imaging , Neurofibroma , Neurofibroma/ultrastructureABSTRACT
EL neurofibroma es un tumor benigno que deriva de las células de Schwann y de los fibroblastos perineurales de los nervios periféricos. Dentro de los tumores de cabeza y cuello, presenta una frecuencia muy baja, pero es el tumor más frecuente de origen neurógeno. Se presentan solitarios o formando parte de la neurofibromatosis múltiples tipo 1 (enfermedad de Von Recklinghausen). El diagnóstico prequirúrgico es dificultoso. Se llega ala diagnóstico definitivo tras el estudio histopatológico de la pieza quirúrgica. Se presenta un caso clínico y se realiza la revisión bibliográfica correspondiente
Subject(s)
Humans , Male , Female , Middle Aged , Neurofibroma/surgery , Neurofibroma/diagnosis , Neurofibroma , Neurofibroma/ultrastructure , Ear, External/injuries , Biopsy/methods , Diagnosis, DifferentialABSTRACT
This report deals with the ultrastructural observations of 30 peripheral nerve sheath tumours [PNST], which include 25 schwannomas of acoustic nerve, one schwannoma of cauda equina, one neurofibroma from a case of Von Recklinghausen's disease, one pigmented neurofibroma of spinal nerve root and a malignant schwannoma of frontal region. Interdigitating slender cytoplasmic processes covered with a continuous layer of basal lamina constitute the single most important ultrastructural attribute of Schwann cells. Myelin formation was encountered in the cell processes of four out of 25 acoustic schwannomas. In four cases Microtubular arrays identical to that in an axon were seen in Schwann cells. These two observations require further support by additional cases of PNST studies by electron microscopy. The neurofibroma consisted only of Schwann cells and no ultrastructurally identifiable perineurial cells or fibroblasts were detected. The cells in the pigmented neurofibroma revealed submicroscopic features of both Schwann cell and melanocyte, indicating their common ancestry. A unique case of malignant schwannoma arising from frontal meninges is illustrated and it is emphasized that electron microscopy is mandatory for a correct histogenetic diagnosis of malignant tumours which occur at unexpected anatomical sites.