ABSTRACT
A 3-year-old boy presented with bluish patch and scattered blue spots on the left side of his face. After several sessions of laser treatment, the azury patch in the periorbital area became even darker. Histopathology showed many bipolar, pigment-laden dendritic cells scattered in the papillary and upper reticular dermis. Immunohistochemically, these cells were positive for S100, SOX-10, melan-A, P16, and HMB-45. The positive rate of Ki-67 was less than 5%. Finally, the lesion was diagnosed with nevus of Ota concurrent with common blue nevus. Therefore, for cases of the nevus of Ota with poor response to laser treatment, the possible coexisting diseases should be suspected.
Subject(s)
Male , Humans , Child, Preschool , Nevus, Blue/pathology , Nevus of Ota/therapy , Skin/pathology , Face , Skin Neoplasms/pathologyABSTRACT
The evaluation of pigmentary skin lesions by clinical doctors has been based on subjective and qualitative judgements. Observations have mostly relied on visual inspection, making the effects of treatment difficult to evaluate with any precision. For this reason there is a real need for an objective method to evaluate prognosis after treatment. Recent scientific measurements such as reflectance spectrophotometry and reflectance colorimetry have provided accurate quantitative color information about skin lesions, but these techniques are costly and difficult to apply in the clinical field. The purpose of this study was to develop a simple and cost-effective way of evaluating treatment results. We have developed a software program using the L*a*b* color coordinate system to quantify the effect of treatment and have successfully demonstrated its clinical usefulness. Our method compares the relative color difference between normal skin and skin lesions before and after treatment, instead of measuring the absolute color of skin lesions. The accuracy of our quantitative color analysis was confirmed by the simulated images of hemangioma and ota nevus. Clinical efficacy was also confirmed through a blind test involving 3 clinicians who were asked to grade the treatment effects of 13 cases of hemangioma and 7 cases of ota nevus. These subjective clinical grades correlated well with the treatment results obtained using the proposed color analysis system (Correlation coefficient = 0.84).
Subject(s)
Female , Humans , Color , Hemangioma/therapy , Hemangioma/pathology , Nevus of Ota/therapy , Nevus of Ota/pathology , Outcome Assessment, Health Care/methods , Pigmentation Disorders/therapy , Pigmentation Disorders/pathology , Skin Neoplasms/therapy , Skin Neoplasms/pathology , Skin Pigmentation , SoftwareABSTRACT
Dentro de las melanocitosis dérmicas el nevo de Ota ocupa un lugar destacado. Presentamos tres nuevos casos con lesiones clásicas. De rara presentación en la raza caucasiana pero más frecuente en la oriental, suele asociarse a problemas oftalmológicos, auditivos y del sistema nervioso central, pero principalmente su posible degeneración hacia un melanoma es lo que debe alertar al especialista para un control cercano de estos pacientes a lo largo del tiempo. Si bien su diagnóstico no suele ofrecer dificultades, se mencionan otras afecciones de presentación clínico-patológica similar. Se pone énfasis en los avances terapéuticos que se han logrado, especialmente con el uso de la técnica laser
Subject(s)
Humans , Male , Female , Infant , Adult , Middle Aged , Nevus of Ota/diagnosis , Nevus of Ota/complications , Nevus of Ota/therapy , Lasers/therapeutic useABSTRACT
El nevo de Ota se agrupa dentro de las melanosis dérmicas, grupo de dermatosis que se caracterizan por la presencia de melanocitos en la dermis. Se presenta una paciente de 24 años de edad, con una melanosis de 10 años de evolución, color azulada, localizada en región malar derecha, región preauricular, ángulo externo de ojo, cuello y hombro, de lento y constante crecimiento. El estudio anatomopatológico confirmó el diagnóstico de nevo de Ota. Se plantean diferentes modalidades terapéuticas