ABSTRACT
Apoptosis and oxidative stress will be studied. The study included 150 pediatric patients admitted to Assiut University children Hospital because of convulsions. Their ages ranged from 6 M- 12y. The study also included 10 apparently healthy children of matchable age as controls. All cases and controls had the following investigations done: complete blood count, serum calcium, glucose, urea and creatinine. Nitric oxide [NO], Total thiobarbituric acid reactive species [TBARS], soluble fas, 5 hydroxytryptamine [5HT], gamma aminobutyric acid [GAB4] and DNA fragmentation percentage. All cases had an EEG done on admission. This study showed that apoptois and oxidative stress were significantly higher in cases than controls. Cases with prolonged and/or focal convulsions showed significantly higher % DNA fragmentation. Cases with simple febrile convulsions, higher degree of rise of temperature and shorter duration of convulsion [<5 minutes] showed significantly higher % DNA fragmentation. Younger cases [<2years] showed significantly higher degree of rise of temperature, oxidative stress and % DNA fragmentation. Cases with [temperature > 39 Degree C] also showed significantly higher % DNA fragmentation and significantly lower GABA levels. Correlation study showed significant positive correlation between % DNA fragmentation and rise of temperature
Conclusion and Recommendations. From this study, it can he concluded that the so called simple febrile convulsions showed significantly higher apoptosis
Recommendations: It is recommended that EEG monitoring should be done during the convulsion to be able to correlate the EEG, findings with the type of convulsion
Subject(s)
Humans , Male , Female , Apoptosis , Oxidative Stress , Nitric Acid/adverse effects , Thiobarbituric Acid Reactive Substances , Infant , ChildABSTRACT
Nitric acid hand burn is rarely described in the literatures, there is no standard policy for management of this injury, and difficulties in assessing the depth of the burned area in the early stages of the disease makes primary excision and skin grafting delayed. The risk of stiff ness of the hand as a result of delay Eschar excision was managed by using krishner wire fixation of the metacarpophalangeal joint in functional position after Eschar excision
Subject(s)
Humans , Male , Hand Injuries/etiology , Hand Injuries/surgery , Nitric Acid/adverse effects , Skin Transplantation , Burns, Chemical/classificationABSTRACT
Se analiza el caso de una paciente que realizó un intento de autoeliminación por inyección intraperitoneal de ácido nítrico. No hemos encontrado comunicaciones similares a la actual en la literatura consultada. Destacaremos elementos de la clínica, la fisiopatología y el tratamiento, así como también analizaremos otras eventuales opciones terapéuticas