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1.
Rev. bras. epidemiol ; 22: e190021, 2019. tab
Article in Portuguese | LILACS | ID: biblio-990733

ABSTRACT

RESUMO: Introdução: O uso de ansiolíticos é uma opção no tratamento de sintomas psíquicos. Contudo, ainda que o uso seja controlado há riscos de dependência, intoxicação e alterações cognitivas. O uso não controlado entre trabalhadores agrava tais problemas. Objetivos: Identificar a prevalência do uso de ansiolíticos e conhecer os fatores associados ao consumo em bombeiros militares. Método: Pesquisa transversal de base censitária investigou 711 bombeiros de Belo Horizonte, Minas Gerais, por meio de autorrelato. Regressão logística multinomial foi utilizada para verificar associação entre características sociodemográficas, condições de vida, trabalho e saúde e consumo de ansiolíticos de modo controlado ou não. Resultados: A prevalência do uso de ansiolíticos foi 9,9%. Para 7,5% dos bombeiros o consumo ocorreu sem indicação e/ou controle terapêutico especializado. O uso controlado foi associado ao relato compatível com Transtorno Mental Comum (OR = 23,6; IC95% 6,54 - 85,11). O uso não controlado foi associado ao tempo de serviço (OR = 2,57; IC95% 1,03 - 6,40), ao tabagismo (OR = 3,22; IC95% 1,50 - 6,91) e ao Transtorno Mental Comum (OR = 4,02; IC95% 2,17 - 7,45). Conclusão: A alta prevalência de consumo indica alerta para as ações dos programas de saúde ocupacional.


ABSTRACT: Introduction: Use of anxiolytic drugs is an option for treating psychological symptoms. However, even if their use is controlled, there are risks of dependence, intoxication and cognitive alterations. Uncontrolled use among workers worsens these problems. Objectives: Identify the prevalence of anxiolytic use and to know the factors associated with consumption in military firefighters. Method: Cross-sectional survey of 711 firefighters from Belo Horizonte, Minas Gerais, Brazil, was conducted through self-reporting. Multinomial logistic regression was used to investigate associations between sociodemographic characteristics, living, working and health conditions and anxiolytic consumption in a controlled or uncontrolled manner. Results: Prevalence of anxiolytic use was 9.9%. For 7.5% of firefighters the consumption occurred without indication and/or specialized therapeutic control. Controlled use was only associated with symptoms compatible with Common Mental Disorder (OR = 23.6; 95%CI 6.54 - 85.11). Uncontrolled use was associated with length of service (OR = 2.57; 95%CI 1.03 - 6.40), smoking (OR = 3.22; 95%CI 1.50 - 6.91) and symptomatology compatible with Common Mental Disorder (OR = 4.02; 95%CI 2.17 - 7.45). Conclusion: The high prevalence of consumption indicates alert to occupational health programs.


Subject(s)
Humans , Male , Anti-Anxiety Agents/therapeutic use , Firefighters/psychology , Mental Disorders/drug therapy , Military Personnel/psychology , Occupational Diseases/drug therapy , Socioeconomic Factors , Brazil/epidemiology , Epidemiologic Methods , Occupational Health , Mental Disorders/epidemiology , Occupational Diseases/epidemiology
2.
J. bras. pneumol ; 42(6): 447-452, Nov.-Dec. 2016. tab, graf
Article in English | LILACS | ID: biblio-841240

ABSTRACT

ABSTRACT Objective: To describe diagnostic and treatment aspects of hard metal lung disease (HMLD) and to review the current literature on the topic. Methods: This was a retrospective study based on the medical records of patients treated at the Occupational Respiratory Diseases Clinic of the Instituto do Coração, in the city of São Paulo, Brazil, between 2010 and 2013. Results: Of 320 patients treated during the study period, 5 (1.56%) were diagnosed with HMLD. All of those 5 patients were male (mean age, 42.0 ± 13.6 years; mean duration of exposure to hard metals, 11.4 ± 8.0 years). Occupational histories were taken, after which the patients underwent clinical evaluation, chest HRCT, pulmonary function tests, bronchoscopy, BAL, and lung biopsy. Restrictive lung disease was found in all subjects. The most common chest HRCT finding was ground glass opacities (in 80%). In 4 patients, BALF revealed multinucleated giant cells. In 3 patients, lung biopsy revealed giant cell interstitial pneumonia. One patient was diagnosed with desquamative interstitial pneumonia associated with cellular bronchiolitis, and another was diagnosed with a hypersensitivity pneumonitis pattern. All patients were withdrawn from exposure and treated with corticosteroid. Clinical improvement occurred in 2 patients, whereas the disease progressed in 3. Conclusions: Although HMLD is a rare entity, it should always be included in the differential diagnosis of respiratory dysfunction in workers with a high occupational risk of exposure to hard metal particles. A relevant history (clinical and occupational) accompanied by chest HRCT and BAL findings suggestive of the disease might be sufficient for the diagnosis.


RESUMO Objetivo: Descrever aspectos relacionados ao diagnóstico e tratamento de pacientes com doença pulmonar por metal duro (DPMD) e realizar uma revisão da literatura. Métodos: Estudo retrospectivo dos prontuários médicos de pacientes atendidos no Serviço de Doenças Respiratórias Ocupacionais do Instituto do Coração, localizado na cidade de São Paulo, entre 2010 e 2013. Resultados: Entre 320 pacientes atendidos no período do estudo, 5 (1,56%) foram diagnosticados com DPMD. Todos os pacientes eram do sexo masculino, com média de idade de 42,0 ± 13,6 anos e média de tempo de exposição a metal duro de 11,4 ± 8,0 anos. Os pacientes foram submetidos a avaliação clinica, história ocupacional, TCAR de tórax, prova de função pulmonar, broncoscopia com LBA e biópsia pulmonar. Todos apresentaram distúrbio ventilatório restritivo. O achado de imagem à TCAR de tórax mais frequente foi de opacidades em vidro fosco (em 80%). Em 4 pacientes, o LBA revelou presença de células gigantes multinucleadas. Em 3, foi diagnosticada pneumonia intersticial por células gigantes na biópsia pulmonar. Houve o diagnóstico de pneumonia intersticial descamativa associada à bronquiolite celular em 1 paciente e de pneumonite de hipersensibilidade em 1. Todos foram afastados da exposição e tratados com corticoide. Houve melhora em 2 pacientes e progressão da doença em 3. Conclusões: Apesar de ser uma entidade rara, a DPMD deve ser sempre considerada em trabalhadores com risco ocupacional elevado de exposição a metais duros. A história clínica e ocupacional associada a achados em TCAR de tórax e LBA sugestivos da doença podem ser suficientes para o diagnóstico.


Subject(s)
Humans , Male , Adult , Middle Aged , Alloys/adverse effects , Alloys/toxicity , Cobalt/adverse effects , Cobalt/toxicity , Lung Diseases, Interstitial/diagnosis , Occupational Diseases/diagnosis , Occupational Exposure/adverse effects , Tungsten/adverse effects , Tungsten/toxicity , Adrenal Cortex Hormones/therapeutic use , Biopsy , Lung Diseases, Interstitial/drug therapy , Lung Diseases, Interstitial/pathology , Lung/diagnostic imaging , Lung/pathology , Occupational Diseases/drug therapy , Occupational Diseases/pathology , Retrospective Studies , Tomography, X-Ray Computed
3.
Ciênc. Saúde Colet. (Impr.) ; 21(12): 3769-3776, 2016. tab
Article in Portuguese | LILACS | ID: biblio-828528

ABSTRACT

Resumo Os motoristas de caminhão têm sido pouco explorados quanto aos problemas de saúde que os acometem e, principalmente, quanto ao seu perfil de consumo de medicamentos. Este estudo teve o objetivo de determinar o uso contínuo de medicamentos, por motoristas de caminhão, e identificar as características profissionais associadas. Para a sua realização, conduziu-se um estudo transversal com motoristas de caminhão estacionados no Pátio de Triagem do Porto de Paranaguá, Paraná, Brasil. Realizou-se uma entrevista com obtenção de dados socioeconômicos, problemas de saúde, condições de trabalho e uso contínuo de medicamentos. Dos motoristas avaliados (n = 665), 21,1% referiram utilizar algum medicamento continuamente, com destaque para o captopril (10,7%), metformina (10,3%), omeprazol (6,2%) e sinvastatina (6,2%). Motoristas com dezesseis anos ou mais de experiência profissional (RP 1,67; IC 95% 1,11-2,51), proprietários do próprio caminhão (RP 1,38; IC 95% 1,03-1,86) e que não possuíam vínculo empregatício formal (RP 1,49; IC 95% 1,11-2,00) apresentaram maior prevalência de uso contínuo de medicamentos. Observa-se que algumas condições de trabalho têm importante papel do uso contínuo de medicamentos pelos motoristas de caminhão.


Abstract Few studies have been conducted on truck drivers with regard to their health problems, especially their drug consumption profile. This study aimed to determine the continuous use of drugs and to identify use-related professional characteristics among this category. A cross-sectional study was carried out with truck drivers parked at the sorting yard of the, Port of Paranaguá, Paraná. An interview to obtain socioeconomic data, data on health problems, working conditions and continued use of medication was performed. Of the drivers evaluated (n = 665), 21.1% reported a continuous use of some medication, mainly captopril (10.7%), metformin (10.3%), omeprazole (6.2%) and simvastatin (6.2%). Drivers with 16 or more years of professional experience (Prevalence Ratio [PR] 1.67; Confidence Interval [CI] 95% 1.11-2.51), truck owners (PR 1.38; CI 95% 1.03-1.86) and without formal labor contract (PR 1.49; CI 95% 1.11-2.00) had a higher prevalence of continuous use of medication. We noted that some working conditions play an important role in the continuous use of drugs by truck drivers.


Subject(s)
Humans , Male , Adult , Middle Aged , Automobile Driving/statistics & numerical data , Motor Vehicles , Occupational Diseases/drug therapy , Occupations , Socioeconomic Factors , Brazil/epidemiology , Prevalence , Cross-Sectional Studies , Interviews as Topic , Risk Factors , Occupational Diseases/epidemiology
4.
Rev. bras. otorrinolaringol ; 74(4): 621-627, jul.-ago. 2008. ilus
Article in English, Portuguese | LILACS | ID: lil-494435

ABSTRACT

Na literatura, a otite média tuberculosa está como uma causa rara de infecção crônica supurativa da orelha média e mastóide, e os fatores predisponentes foram pouco referidos. Em nosso país há um aumento da incidência de tuberculose, inclusive de formas raras como a otite média tuberculosa. Esses pacientes classicamente têm múltiplas perfurações da membrana timpânica e otorréia, associada à perda auditiva progressiva. O diagnóstico deve ser aventado nos pacientes com otite que não responde a terapia de rotina, seja por fungo da orelha externa ou bacteriana da orelha média. Os autores apresentam, em estudo retrospectivo, quatro pacientes com otite média tuberculosas, sendo duas médicas, uma engenheira química e um menor com casos de tuberculose ativa na família, sendo, portanto, fatores predisponentes o contato familiar com tuberculoso, contato profissional e exposição a agressores de vias aéreas.


Tuberculosis is a rare cause of chronic suppurative otitis media and mastoiditis; the predisposing factors of this association, however, are not commonly described. There has been an alarming increase in the incidence of tuberculosis in Brazil, including tuberculous otitis media. These patients typically present multiple perforations of the tympanic membrane, an ear discharge, and progressive hearing loss. This diagnosis should be taken into account in patients that do not respond to routine therapy for fungal external otitis or bacterial otitis media. In this retrospective study, the authors describe four cases of patients with tuberculous otitis media. This sample consisted of two physicians, a chemical engineer and an underage child in whose family there were cases of active tuberculosis. Predisposing factors for tuberculous otitis were contact with family members that had tuberculosis, professional contact with patients and exposure to pathogenic microorganisms in airways.


Subject(s)
Adult , Child , Female , Humans , Male , Ear Diseases/diagnosis , Mycobacterium tuberculosis/isolation & purification , Occupational Diseases/diagnosis , Tuberculosis/diagnosis , Antitubercular Agents/therapeutic use , Ear Diseases/drug therapy , Isoniazid/therapeutic use , Occupational Diseases/drug therapy , Pyrazinamide/therapeutic use , Retrospective Studies , Risk Factors , Rifampin/therapeutic use , Tuberculosis, Pulmonary/diagnosis , Tuberculosis, Pulmonary/drug therapy , Tuberculosis/drug therapy
5.
Journal of Korean Medical Science ; : 941-946, 2005.
Article in English | WPRIM | ID: wpr-16328

ABSTRACT

Eleven cases of human brucellosis occurred among livestock workers and a veterinarian who lived and worked in a rural area around Jeongeup City, Jeollabuk-Do, Korea from February 2003 to August 2003. Eight of the patients had taken care of Korean native cattle that were infected with bovine brucellosis and had already been slaughtered. Two of the patients had taken care of dairy cattle, and one case was a veterinarian who acquired the disease through an accidental contact with infected cattle while assisting in calf delivery. Eleven cases were identified by serologic work ups and four cases were identified via positive blood cultures. This study shows that the Republic of Korea is no longer free of human brucellosis, Brucella abortus biotype 1. We reviewed the patients' characteristics and serologic data during the oneyear follow up period, and we also discuss on the efficacy and side effects of the rifampin and doxycyline regimen used for the treatment of human brucellosis.


Subject(s)
Adult , Animals , Cattle , Female , Humans , Male , Middle Aged , Animal Husbandry , Anti-Bacterial Agents/adverse effects , Antibodies, Bacterial/blood , Base Sequence , Brucella abortus/genetics , Brucellosis/drug therapy , Brucellosis, Bovine/transmission , DNA, Bacterial/genetics , Disease Outbreaks , Doxycycline/adverse effects , Korea/epidemiology , Occupational Diseases/drug therapy , Rifampin/adverse effects , Veterinarians
6.
Bol. Asoc. Méd. P. R ; 96(2): 103-110, Mar.-Apr. 2004.
Article in English | LILACS | ID: lil-411066

ABSTRACT

INTRODUCTION: Vision and eye related problems are common among computer users, and have been collectively called the Computer Vision Syndrome (CVS). METHODS: An observational study in order to identify the risk factors leading to the CVS was done. Twenty-eight participants answered a validated questionnaire, and had their workstations examined. The questionnaire evaluated personal, environmental, ergonomic factors, and physiologic response of computer users. The distance from the eye to the computers' monitor (A), the computers' monitor height (B), and visual axis height (C) were measured. The difference between B and C was calculated and labeled as D. Angles of gaze to the computer monitor were calculated using the formula: angle=tan(-1)(D/ A). Angles were divided into two groups: participants with angles of gaze ranging from 0 degrees to 13.9 degrees were included in Group 1; and participants gazing at angles larger than 14 degrees were included in Group 2. Statistical analysis of the evaluated variables was made. RESULTS: Computer users in both groups used more tear supplements (as part of the syndrome) than expected. This association was statistically significant (p<0.10). Participants in Group 1 reported more pain than participants in Group 2. Associations between the CVS and other personal or ergonomic variables were not statistically significant. CONCLUSIONS: Our findings show that most important factor leading to the syndrome is the angle of gaze at the computer monitor. Pain in computer users is diminished when gazing downwards at angles of 14 degrees or more. The CVS remains an under estimated and poorly understood issue at the workplace. The general public, health professionals, the government, and private industries need to be educated about the CVS


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Asthenopia/etiology , Computer Terminals , Occupational Diseases/etiology , Dry Eye Syndromes/etiology , Asthenopia/prevention & control , Neck Pain/etiology , Neck Pain/prevention & control , Occupational Diseases/drug therapy , Occupational Diseases/prevention & control , Back Pain/etiology , Back Pain/prevention & control , Ergonomics , Interior Design and Furnishings , Medical Secretaries , Physicians' Offices , Prospective Studies , Surveys and Questionnaires , Risk Factors , Syndrome , Dry Eye Syndromes/drug therapy , Dry Eye Syndromes/prevention & control , Ophthalmic Solutions/therapeutic use , Workplace
7.
Medicina (B.Aires) ; 59(4): 367-9, 1999. ilus
Article in Spanish | LILACS | ID: lil-247896

ABSTRACT

La neumonitis por hipersensibilidad (NH) es la manifestación clínica de una reación inmunológica en el pulmón ante una variedad de antigenos inhalados. La lista de antígenos provocadores y enfermedades específicas crece permanentemente. Se presenta una mujer de 56 años que consultó por disnea de dos meses de evolución y tos poco productiva. Trabajaba en una fábrica de embutidos sopleteando el polvillo que recubre los salamines durante su estacionamiento. Presenta hipoxemia y una espirometria con patrón predominantemente obstructivo. La radiografia de tórax fue normal y la TAC de tórax de alta resolución mostró patrón en mosaico. La biopsia de pulmón confirmó el diagnóstico de NH. La paciente respondió al tratamiento con corticoides sistémicos y al alejamiento de la exposición laboral. El material que recubre los salamines cultivó Penicillium spp, el cual se interpretó como probable agente etiológico de esta NH, a la que llamamos "pulmón del sopleteador de salamines".


Subject(s)
Humans , Female , Middle Aged , Alveolitis, Extrinsic Allergic/diagnosis , Alveolitis, Extrinsic Allergic/drug therapy , Alveolitis, Extrinsic Allergic/microbiology , Dust , Food , Glucocorticoids/therapeutic use , Methylprednisolone/therapeutic use , Occupational Diseases/diagnosis , Occupational Diseases/drug therapy , Penicillium/isolation & purification
11.
Article in English | IMSEAR | ID: sea-21784

ABSTRACT

Twelve culture proven patients of sporotrichosis were seen over a period of 4 1/2 yr in the north-western region of this country. Most of the patients (75%) were from Himachal Pradesh, with slight female preponderance. The right upper limb was commonly (58.3%) involved; gardeners and housewives being the common sufferers. Localised lymphocutaneous variety was the commonest presentation (91.7%), except in one patient, where after initial involvement of the face, the lesion extended to the right upper limb and trunk. All but one patient responded to oral potassium iodide therapy; this patient with mixed infection of Sporothrix schenckii and Cladosporium species, required in addition, amphotericin B therapy.


Subject(s)
Amphotericin B/therapeutic use , Female , Humans , India , Male , Middle Aged , Occupational Diseases/drug therapy , Potassium Iodide/therapeutic use , Sex Factors , Sporotrichosis/drug therapy
12.
Acta méd. colomb ; 18(5): 268-73, sept.-oct. 1993.
Article in Spanish | LILACS | ID: lil-183312

ABSTRACT

La bronquitis industrial es un término recientemente introducido, pero poco utilizado relativamente desconocido. Su definición se refiere a aquellos pacientes que cumplen los criterios de bronquitis crónica con o sin obstrucción al flujo aéreo, no fumadores y que tienen como único antecedente la exposición industrial o ambiental. Con el desarrollo social, tecnológico y la creación de industrias, desde la época de la revolución industrial, el ser humano ha tenido que enfrentarse a un medio ambiente laboral polucionado, consecuentemente ha desarrollado enfermedades pulmonares. El impacto sobre el sistema respiratorio ha sido relevante y éste a su vez redunda en la reducción de la productividad. Para aplicar las medidas de prevención y control deben primero conocerse las entidades. Por ello la presente revisión.


Subject(s)
Humans , Bronchitis/classification , Bronchitis/complications , Bronchitis/diagnosis , Bronchitis/drug therapy , Bronchitis/etiology , Bronchitis/mortality , Bronchitis/physiopathology , Bronchitis/therapy , Industrial Pollutants , Occupational Diseases/classification , Occupational Diseases/complications , Occupational Diseases/diagnosis , Occupational Diseases/drug therapy , Occupational Diseases/epidemiology , Occupational Diseases/mortality , Occupational Diseases/physiopathology , Occupational Diseases/therapy
13.
Arch. argent. alerg. inmunol. clín ; 24(4): 155-65, 1993. ilus
Article in Spanish | LILACS | ID: lil-129850

ABSTRACT

Año 1979 - NUTTER reporta un caso de Urticaria de Contacto producida por sensibilización alérgica al látex (Lx). 11 de marzo de 1991 - La Food and drug Administration (FDA) emite un "comunicado" de alerta advirtiendo a los profesionales de la salud sobre reacciones alérgicas a elementos de uso médico que contienen Lx. Es evidente que la alergia al Lx se ha constituido en los últimos años en una preocupación creciente, tanto por la variedad como por la gravedad de sus manifestaciones clínicas y particularmente porque en muchos casos su etiología permanece ignorada o atribuida a otras causas. Los alergenos del Lx se hallan en los componentes proteicos contenidos en la savia natural del árbol hevea brasiliensis con capacidad para reacciones de hipersensibilidad inmediata mediada por IgE específica y ser causa de rinoconjuntivitis, asma bronquial, urticarias, angiedemas y anafilaxia, en ocasiones con muerte del paciente. Los productos elaborados con Lx también pueden producir reacciones de Tipo IV como eczemas, y dermatitis de contacto atribuidas mayoritariamente a los aditivos usados en la fabricación como son los componentes de los grupos Thiuram, Naftil, Carba y Mercapto. Fundamentamente afecta a tres Grupos de Riesgo bien determinados y caracterizados por tener un alto grado de exposición al Lx. 1) Niños con Espina Bifida y/o malformaciones genitourinarias 18 por ciento a 40 por ciento; 2) Trabajadores de la salud (Médicos y enfermeras de cirugía) 5,4 por ciento a 11 por ciento; 3) Trabajadores de la industria del caucho 6,2 por ciento a 11 por ciento. Sin constituir un grupo determinado de riesgo son posibles de sensibilizarse al Lx las personas que habitualmente usan preservativos, enfermos con repetidas operaciones quirúrgicas y aquellos que por distintas razones están expuestos al Lx. El diagnóstico se fundamenta en un prolijo análisis de antecedentes de exposición. Pruebas cutáneas con Lx natural, Lx amoniacado y extractos obtenidos de productos finales (guantes), determinación de IgE Específica por RAST o ELISA como así también Test de Parches con Lx y aditivos de los grupos mencionados. El tratamiento se fundamenta en la Evitación y en la Prevención. En el primer caso evitando el contacto o reemplazando el Lx por otros materiales como vinílicos y Lx sintéticos (Elastiren, Neopreno y Dactylon). Se estable la prevención Prequirúrgica en aquellos casos de riesgo aplicando bloqueadores H1, H2 y corticoides. Existe unanimidad en todos los autores para difundir su conocimiento en médicos alergistas, cirujanos, neurólogos, anestesistas, radiólogos, odontólogos y enfermeras además de las familias con niños con espina bífida dado que su causalidad, tiende a permanecer encubierta


Subject(s)
Humans , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Dermatitis, Contact/etiology , Latex/adverse effects , Occupational Diseases/prevention & control , Dermatitis, Contact/physiopathology , Dermatitis, Contact/prevention & control , Dermatitis, Occupational/diagnosis , Dermatitis, Occupational/drug therapy , Dermatitis, Occupational/prevention & control , Occupational Diseases/diagnosis , Occupational Diseases/drug therapy , Premedication/standards , Clinical Protocols/standards , Risk Groups
14.
In. Assunçäo, Ada Avila; Silveira, Andréa Maria; Dias, Elizabeth Costa; Silva, Jandira Maciel da; Rigotto, Raquel Maria. Manual de rotinas: ambulatório de doenças profissionais. s.l, Imprensa Universitária da UFMG, 1992. p.53-66, ilus.
Monography in Portuguese | LILACS | ID: lil-124528
17.
Rev. bras. clín. ter ; 14(10): 352-7, out. 1985. tab, ilus
Article in Portuguese | LILACS | ID: lil-33886

ABSTRACT

Trinta e cinco pacientes portadores de dermatites de contato ocupacionais, agudas, subagudas e crônicas, foram submetidos à terapêutica tópica com creme ou pomada de acetonil-triamcinolona a 0,1% em duas aplicaçöes diárias por um período de 17 a 30 dias. As afecçöes em 28 casos (80%) foram classificadas como de intensidade moderada ou grave, sendo que, destes, 23 pacientes já referiam dois ou mais tratamentos prévios com resultados insatisfatórios. Mais da metade dos casos observados (20 pacientes, 57,14%) foram representados por dermatites ocupacionais à produtos de limpeza, em donas-de-casa. A eficácia do tratamento foi avaliada subjetiva e objetivamente através de controles semanais por um período máximo de quatro semanas. Os resultados finais foram excelentes em 27 casos (77,14%) e bons nos restantes 8 casos (22,86%), com um total de 100% dos casos com evoluçäo satisfatória. Näo foram observados efeitos colaterais ou reaçöes de irritaçäo ou hipersensibilidade local em nenhum caso. A acetonil-triamcinolona a 0,1% associada a antibióticos e antimicótico revelou-se uma excelente opçäo terapêutica no tratamento de dermatites de contato de natureza ocupacional; eficaz e praticamente desprovida de efeitos secundários


Subject(s)
Child , Adolescent , Adult , Middle Aged , Humans , Male , Female , Antifungal Agents/therapeutic use , Anti-Bacterial Agents/therapeutic use , Dermatitis, Contact/drug therapy , Occupational Diseases/drug therapy , Triamcinolone Acetonide/therapeutic use , Drug Therapy, Combination
18.
Bahrain Medical Bulletin. 1984; 6 (2): 62-6
in English | IMEMR | ID: emr-3957

ABSTRACT

It is important to evolve bio-monitoring systems in occupational situations as problematic as pesticide exposure. In occupational situations the exposure to pesticide is generally of a subthreshold level, of long standing and to a mixed group of compounds. The organophosphates and carbamates are anticholinesterases, with largely similar biological effects, but with slightly different biotransformation pathways. The validity of the anticholinesterase kinetics is based on specific "selectophore" molecules which take part in the different phases of activation and degradation of the pesticides. The judicial use of critical and precise enzymatic changes, like those of glucronyl transferase with cholinesterase, are supplementary in the biomonitoring of people in pesticide exposure. In this article the rationale of using the anticholinesterase system is described, and correlations between the broad and general physicochemical structure function relationships of these pesticides and specific biological activity at target sites are illustrated. The secondary reactions such as those of detoxification/inactivation, are an equally important component of any biomonitoring system. Some of these should be incorporated into the study especially of long term/chronic subthreshold exposure, to be able to explain better the late occuring clinical pictures of pesticide exposure


Subject(s)
Pesticides/adverse effects , Kinetics , Occupational Diseases/drug therapy
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