Lipid peroxidation and concentrations of reduced glutathione in erythrocytes of workers exposed to diesel engine exhaust

The study was carried out to investigate the effect of diesel engine exhaust inhalation on a total number of 50 male subjects from a bus garage located in Alexandria. The present study showed a significant higher level of lipid peroxidation expressed as malonyldialdehyde [MDA]. The increase in lipid peroxidation was associated with a significant decrease in glutathione [GSH] and an increase in the level of glutathione peroxidase [GSH-PX] activities. Also, the results showed significant changes in the levels of lipid profile of workers exposed to diesel than the control subjects which may lead to inflammation involving damage of the epithelial cells in the airways and alveolar regions of the lung