ABSTRACT
Resumo Mieloma múltiplo (MM) é uma neoplasia que cursa com a proliferação desordenada de clones de plasmócitos, produzindo imunoglobulina monoclonal e normalmente se apresenta como lesões osteolíticas. Em alguns casos, porém, esta doença apresenta-se como massas, chamadas de plasmocitomas. O acometimento ocular e orbitário é incomum nesta patologia. Neste trabalho, descrevemos o caso de uma paciente de 63 anos com diagnóstico prévio de MM que evoluiu com um plasmocitoma intraconal em olho direito, bem como uma massa vascularizada câmara anterior proveniente de infiltração uveal. Essas lesões foram correlacionadas MM e culminaram com a perda visual no olho acometido. Não foi encontrado na literatura relatos de plasmocitoma intraconal.
Abstract Multiple myeloma (MM) leads to disorderly proliferation of plasma cells clones, producing monoclonal immunoglobulin and commonly presents osteolytic lesions. In some cases, however, masses called plasmocytomas are found. Ocular and orbital involvement is unusual in this pathology. In this paper, we describe a case of a 63 year-old patient with previous diagnostic of MM that evolved an intraconal plasmocytoma in the right eye, as well as a vascularized mass in the anterior chamber from uveal infiltration. These lesions were correlated to MM e lead to visual loss in the affected eye. Reports of intraconal plasmocytoma have not been found in literature.
Subject(s)
Humans , Female , Middle Aged , Plasmacytoma/diagnosis , Orbital Neoplasms/diagnosis , Multiple Myeloma/diagnosis , Ophthalmoscopy , Plasmacytoma/drug therapy , Biopsy , Dexamethasone/therapeutic use , Orbital Neoplasms/pathology , Orbital Neoplasms/drug therapy , Magnetic Resonance Imaging , Visual Acuity , Tomography, X-Ray Computed , Ultrasonography , Cyclophosphamide/therapeutic use , Bortezomib/therapeutic use , Slit Lamp Microscopy , Intraocular Pressure , Multiple Myeloma/pathologyABSTRACT
Primitive neuroectodermal tumor is a small round cell malignancy which rarely involves the orbit. We report a case of a two-year old male child presenting as unilateral eccentric proptosis with extraconal and intraconal mass, diagnosed as primary peripheral primitive neuroectodermal tumor (pPPNET) on histopathology and immunohistochemistry. There is no defined consensus in the management of these tumors due to its rare presentation. We describe its distinguishing features with emphasis on multimodal and aggressive treatment approach which ensures appropriate management of these cases.
Subject(s)
Antineoplastic Agents/therapeutic use , Biopsy , Child, Preschool , Follow-Up Studies , Humans , Magnetic Resonance Imaging , Male , Neuroectodermal Tumors, Primitive, Peripheral/diagnosis , Neuroectodermal Tumors, Primitive, Peripheral/drug therapy , Neuroectodermal Tumors, Primitive, Peripheral/radiotherapy , Orbital Neoplasms/diagnosis , Orbital Neoplasms/drug therapy , Orbital Neoplasms/radiotherapy , Radiotherapy, Adjuvant , Tomography, X-Ray ComputedSubject(s)
Anti-Bacterial Agents/therapeutic use , Antiviral Agents/therapeutic use , Chlamydophila psittaci/isolation & purification , Eye Infections, Bacterial , Eye Infections, Viral , Hepacivirus/isolation & purification , Hepatitis C, Chronic/drug therapy , Humans , Lymphoma, B-Cell, Marginal Zone/drug therapy , Orbital Neoplasms/drug therapy , Psittacosis/drug therapyABSTRACT
O objetivo é relatar manifestação incomum de linfoma não-Hodgkin de órbita. Paciente masculino, de 75 anos, se apresentou com queixa de lacrimejamento crônico bilateral. Havia feito dacriocistorrinostomia endonasal à direita e à esquerda por duas vezes, sem sucesso. Ao exame, massas de consistência fibroelástica, em topografia das "bolsas" de gordura das pálpebras inferiores e proptose axial. O paciente negava outros sintomas ou sinais sistêmicos. Hemograma sem alteração, hormônios tireoidianos normais. A tomografia computadorizada mostrava infiltrado difuso na órbita e proptose axial. Biópsia de gordura orbitária e de medula óssea diagnosticaram linfoma não-Hodgkin. O paciente foi tratado com quimioterapia, sendo em seguida submetido à cirurgia da via lacrimal bilateral, com resolução do quadro. A doença sistêmica que exigia diagnóstico e tratamento adequados para que se tivesse bom prognóstico estava mascarada pelo quadro de epífora bilateral.
The purpose is to report an unusual case of orbital non-Hodgkin lymphoma. A 75-year-old man presented with bilateral chronic epiphora complaint and inferior eyelid tumors, axial proptosis, without previous systemic manifestation. The patient was submitted to bilateral endonasal dacryocystorhinostomy twice and the epiphora complaint persisted. The inferior eyelid and bone marrow biopsy revealed non-Hodgkin lymphoma. The patient was treated with systemic chemotherapy and dacryocystorhinostomy with good resolution. The precise diagnosis and the treatment were very important to reach a good resolution of the bilateral epiphora complaint.
Subject(s)
Aged , Humans , Male , Lacrimal Apparatus Diseases , Lymphoma, Non-Hodgkin/pathology , Orbital Neoplasms/pathology , Chronic Disease , Dacryocystorhinostomy , Exophthalmos/diagnosis , Eyelid Neoplasms/pathology , Lacrimal Apparatus Diseases , Lacrimal Apparatus Diseases/surgery , Lymphoma, Non-Hodgkin/drug therapy , Orbital Neoplasms/drug therapy , Treatment FailureABSTRACT
We report a 38-year-old HIV positive female, who developed an acute attack of herpes zoster HZ involving the mandibular, C2, C3, C4, T1, and T2 dermatomes, 9 days after the commencement of the first cycle of chemotherapy regimen for non-Hodgkin's lymphoma NHL. She had developed NHL of the ovary approximately 6 months earlier, followed by metastasis to the left orbit resulting in proptosis of the left eye. A combination of a positive HIV status, lymphoma, and chemotherapy can predispose a patient to an attack of HZ involving many dermatomes
Subject(s)
Humans , Female , Orbital Neoplasms/drug therapy , Herpes Zoster/etiology , HIV Seropositivity/drug therapy , HIV Seropositivity/complications , Antineoplastic Combined Chemotherapy Protocols , Antiretroviral Therapy, Highly ActiveABSTRACT
Dentro del grupo de los tumores malignos epiteliales de las fosas nasales y antro maxilar, el carcinoma mucoepidermoide es el más raro. La participación orbitaria es frecuente y se ilustra con dos casos, uno con participación de la cavidad nasal y antro maxilar y el otro exclusivamente del antro maxilar. Las manifestaciones clínicas dependen de las alteraciones mecánicas musculares y la proptosis; las más frecuentes son: exoftalmo no reductible, disminución de la capacidad visual hasta llegar a la ceguera y deformación facial. La tomografía y resonancia nuclear magnética son muy útiles en el diagnóstico y pronóstico. El pronóstico es malo tanto para la función como para la vida. El tratamiento es eminenetemente quirúrgico, la radioterapia y quimioterapia son paliativos y con severas complicaciones deletéreas
Subject(s)
Humans , Male , Female , Middle Aged , Orbital Neoplasms/surgery , Orbital Neoplasms/drug therapy , Orbital Neoplasms/radiotherapy , Paranasal Sinus Neoplasms , Carcinoma, Mucoepidermoid/surgery , Carcinoma, Mucoepidermoid/pathology , Carcinoma, Mucoepidermoid/therapy , Head and Neck Neoplasms , Ophthalmology , Tomography , Magnetic Resonance SpectroscopyABSTRACT
Apresentamos um caso de "pseudotumor" de órbita e discutimos os aspectos diagnósticos e histopatológicos desta inusitada afecçäo da órbita
Subject(s)
Middle Aged , Humans , Male , Orbital Neoplasms/diagnosis , Prednisone/therapeutic use , Tomography, X-Ray Computed , Orbital Neoplasms/surgery , Orbital Neoplasms/pathology , Orbital Neoplasms/drug therapyABSTRACT
Los tumores linfoides siempre representan un problema diagnóstico, tanto clínico como histopatológico. Se presenta un niño de 4 años con linfomas de Burkitt, cuya manifestación clínica fue proptosis y tumoración en hemicara izquierda. Se hace una revisión de la enfermedad mencionando su distribución universal, su mayor frecuencia en niños entre 2 y 15 años, así como su localización mandibular y abdominal. Se mencionan las características histológicas distintivas y el resultado obtenido con tratamiento combinado de quimioterapia y radioterapia