ABSTRACT
OBJECTIVE@#To observe rule of medicine concentration of blood and the last concentration that through hemoperfusion after poisoned by acephate.@*METHODS@#Utilizeng the patient annual bonus venous blood in hospital emergency room, the content of acephate in plasma was analyzed by gas chromatography.@*RESULTS@#After hemoperfusion, the concentration of acephate showed a rapid drop and the characteristic that the concentration drops quicker if medicine concentration of blood before hemoperfusion is higher.@*CONCLUSION@#Hemoperfusion is able to rapidly reduce the concentration of acephate in blood, its speed is determined by initial concentration and the beginning time of hemoperfusion etc.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Acute Disease , Charcoal/therapeutic use , Chromatography, Gas , Coma/therapy , Emergency Service, Hospital , Hemoperfusion , Organothiophosphorus Compounds/poisoning , Phosphoramides , Poisoning/therapy , Time FactorsSubject(s)
Adult , Female , Food Contamination , Humans , Insecticides/poisoning , Male , Middle Aged , Organothiophosphorus Compounds/poisoning , VegetablesABSTRACT
Acephate, an organophosphorus insecticide (60 mg/day/rat) disturbed the carbohydrate metabolism in albino rats (wt. between 100-150 gms). Changes in the enzyme activities in the liver were estimated in the rats after oral administration of Acephate. The specific activities of succinic dehydrogenase was decreased in experimental rats than control. A gradual decrease in blood and liver glutathione was also observed. Increase in total lactate dehydrogenase was also noted. It has been observed that in the liver homogenate of treated rats, the isoenzymes LDH4+5 were increased, LDH1+2 were decreased while LDH3 remain unchanged with respect to control value.