ABSTRACT
Abstract Some epidermal alterations in measles has been described, such as keratinocytes apoptotic, parakeratosis, giant-cell formation, intranuclear and cytoplasmic inclusions, dyskeratosis, spongiosis, and intracellular edema. The authors report for the first time in human a case of measles with the presence of multinucleated giant cells in the hair follicle and dyskeratosis in acrosyringium.
Subject(s)
Humans , Male , Child , Hair Follicle/pathology , Epidermis/pathology , Measles/pathology , Parakeratosis/pathology , Biopsy , Giant Cells/pathology , Keratinocytes/pathologyABSTRACT
Abstract: Porokeratotic eccrine and hair follicle nevus is a very rare non-hereditary disorder of keratinization with eccrine and hair follicle involvement with only 9 cases described in the literature. In 2009 the term porokeratotic anexial ostial nevus was proposed to comprehend porokeratotic eccrine and hair follicle nevus and a related and more common process without follicular involvement: porokeratotic eccrine ostial and dermal duct nevus Recent findings suggest that both entities may be produced by a mutation in GJB2 gene, which is associated to KID syndrome. Herein we report 2 cases of porokeratotic eccrine and hair follicle nevus and review the existing cases in the Spanish and English literature.
Subject(s)
Humans , Male , Female , Infant, Newborn , Adult , Sweat Gland Diseases/pathology , Porokeratosis/pathology , Hair Follicle/pathology , Eccrine Glands/pathology , Hamartoma/pathology , Nevus/pathology , Parakeratosis/pathology , Biopsy , Rare Diseases , Hair Diseases/pathologyABSTRACT
Abstract: Background: Psoriasis is a chronic inflammatory skin disease that often progresses with nail alterations. It is suspected that there is a correlation between nail psoriasis and enthesitis of the distal interphalangeal joint, seeming to serve as a predictor. Objectives: To analyze the profile of patients with nail psoriasis and correlate the presence of nail alterations with psoriatic arthritis, quality of life, extent of psoriasis and the histopathology of the nail. Methods: An observational cross-sectional study with 40 patients with a diagnosis of psoriasis and without systemic treatment. The patient profile was researched, including quality of life and evaluated for the presence of psoriatic arthritis. The severity of the skin psoriasis and the presence of nail lesions were evaluated. Nail fragments were collected and analyzed through clipping. It obtained 100% of positivity for psoriasis in the histopathology exam of the nail plate. Results: Of the 40 patients, 65% were diagnosed with nail psoriasis. Suggestive findings of psoriatic arthritis in hands were present in 33%, being more frequent in those with nail alteration (p = 0.01). In 92.3% of patients diagnosed with psoriatic arthritis in the hands there was some nail injury. The most frequent injuries were pitting and onycholysis. Conclusions: Patients with nail psoriasis are usually men, with worse quality of life and higher chance of psoriatic arthritis. The correlation between the nail involvement of psoriasis and psoriatic arthritis in hands confirms the association between these two forms. The clinical diagnosis of nail psoriasis did not correlate with the histological diagnosis.
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Psoriasis/epidemiology , Nail Diseases/epidemiology , Parakeratosis/pathology , Psoriasis/pathology , Quality of Life , Severity of Illness Index , Brazil/epidemiology , Arthritis, Psoriatic/complications , Arthritis, Psoriatic/epidemiology , Incidence , Cross-Sectional Studies , Sex Distribution , Onycholysis/epidemiology , Hospitals, University/statistics & numerical data , Nail Diseases/pathologyABSTRACT
La paraqueratosis granular es un desorden de la queratinización adquirido, secundario a un error en la diferenciación epidérmica. Se presenta en forma de pápulas y placas pruriginosas, eritematosas o de color marrón oscuro, que afectan áreas intertriginosas. Su patogénesis es desconocida, pero algunos casos han sido relacionados con ciertos factores, tales como irritantes físicos o agentes químicos. Entre los hallazgos histopatológicos se incluyen un estrato córneo engrosado, paraqueratosis compacta con retención de gránulos de queratohialina, mientras que el estrato granuloso está preservado. Presentamos un caso de paraqueratosis granular axilar en una mujer y se revisan las principales características clínicas, histológicas y terapéuticas de esta inusual entidad.
Granular parakeratosis is a rare acquired keratinization disorder suspected as a consequence of an error in epidermal differentiation. Clinically it appears as dark or erythematous pruritic papules and plaques, that usually involve intertriginous areas. The pathogenesis of this entity is unknown, but some cases have been related to different factors, such as physical irritation or chemical agents. Histopathologic features include a thickened stratum corneum, compact parakeratosis with retention of keratohyalin granules whereas the stratum granulosum is preserved. We report a case of axillary granular parakeratosis in an adult female and a revision of the clinical, therapeutic and histological features of this unusual entity
Subject(s)
Humans , Adult , Parakeratosis/diagnosis , Parakeratosis/pathology , Axilla/pathologyABSTRACT
La paraqueratosis granular es una dermatosis de probable etiología reaccional descripta en la última década. Se presenta como pápulas hiperqueratósicas y eritematosas que confluyen formando placas de aspecto reticulado. Predomina en mujeres de entre 50 y 60 años, en zona de pliegues, particularmente axilares. Comunicamos un caso de paraqueratosis granular axilar, el primero dentro de la literatura médica argentina, y revisamos la bibliografía sobre el tema.
Granular parakeratosis is a cutaneous eruption probably due to a re-active mechanism described during the past decade. It has hyper-keratotic erythematous papules that coalesce into reticular plaques.Women are mostly affected, in their 5th to 6th decade, with a prefer-ence for axillary folds. This is the first report of a patient a with axillarygranular parakeratosis in Argentina, and review the medical literature on this condition.
Subject(s)
Humans , Female , Aged , Parakeratosis/diagnosis , Parakeratosis/pathology , Parakeratosis/drug therapy , Administration, Topical , Axilla/pathology , KeratinsABSTRACT
This is a report of a 60 year-old black female patient presenting with pruritic brownish crusted plaques on both axillae of one month evolution. Histopathology revealed findings characteristic of axillary granular parakeratosis. This entity was first described by Northcutt et al in 1991. Since then, involvement of other intertriginous areas have also been reported. A review of the literature was performed and the term granular parakeratosis is suggested to emphasize its pathognomonic histopathologic features
Subject(s)
Humans , Female , Middle Aged , Parakeratosis/pathologyABSTRACT
Se estudió la frecuencia de frotis alterados en citología ginecológica con células escamosas en miniatura, CEM. En 5000 frotis consecutivos se analizaron todos aquéllos que contenían CEM. Se recolectaron 233 casos con CEM 4,66 por ciento. La frecuencia general de fortis alterados fue de 2,04 por ciento; mientras que esta frecuencia fue de 24,89 por ciento en casos con CEM, p< 10 -8. Ciento catorce frotis con CEM tenían patrón atrófico y 10,5 por ciento de ellos eran alterados; 119 frotis con CEM eran estrogénicos o progestativos y 38,7 por ciento de ellos eran alterados p< 0,05. El 53,2 por ciento de frotis con CEM y gránulos de queratohialina tuvieron diagnóstico de lesión epitelial o frotis atípico, mientras que sólo el 10,4 por ciento de casos con CEM y ausencia de gránulos tuvo estos diagnósticos p< 10 -6. La frecuencia de frotis alterados fue significativamente mayor que la general en casos con CEM, partícularmente en frotis no atróficos o con gránulos de queratohialina