ABSTRACT
Os vírus HTLV-I e HTLV-II são endêmicos em algumas regiões do Brasil, onde uma das doenças associadas, a paraparesia espástica tropical/mielopatia associada ao HTLV (PET/MAH), tem sido diagnosticada em significativo número de pacientes infectados. Nesses indivíduos, a prevalência de tuberculose é maior que na população geral, sugerindo que possa haver um maior risco para esta comorbidade. Relatamos o caso de um homem de 44 anos coinfectado HTLV-I + HTLV-II que desenvolveu meningoencefalomielite por Mycobacterium tuberculosis. O paciente apresentou recuperação clínica parcial, correção da disfunção de barreira hemato-liquórica e negativação no PCR, mediante o tratamento com corticoesteróides e tuberculostáticos.
Subject(s)
Adult , Humans , Male , Encephalomyelitis/complications , HTLV-I Infections/complications , HTLV-II Infections/complications , Tuberculosis, Meningeal/complications , Cerebrospinal Fluid Proteins/analysis , Encephalomyelitis/microbiology , HTLV-I Infections/microbiology , HTLV-II Infections/microbiology , Immunocompromised Host , Mycobacterium tuberculosis/isolation & purification , Paraparesis, Tropical Spastic/complications , Paraparesis, Tropical Spastic/microbiologyABSTRACT
The seroprevalence of HTLV-I was studied in parents, brothers, siblings and sexual partners of 147 patients with spastic paraparesis assocaited to HTLV-1 (HAM/TSP) and 84 patients with HTLV-1 negative spastic pararparesis (SP). Seroprevalence was 29.1 percent for HAM/SP and 0 percent for SP relatives (p<0.001); the last figure is similar to that of the general population. Seroprevalence in sexual partners was 65 percent, suggesting that sexual intercourse is the principal route of transmission. Likewise, seroprevalence in siblings of mothers with HAM/TSP or HTLV-1 positive was 17.6 percent, suggesting a high maternal transmission
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Human T-lymphotropic virus 1/pathogenicity , HTLV-I Infections/epidemiology , Paraparesis, Tropical Spastic/microbiology , Parents , Serologic Tests , HTLV-I Infections/transmission , Contact Tracing/statistics & numerical data , Spouses , MothersABSTRACT
El virus HTLV-I fue encontrado promotor de la Leucemia T del adulto y de la paraparesia espástica tropical. No es el único virus inculpado con la producción de neoplasias en el hombre. Se trata de un virus muy similar al HTLV-II o HIV, que se propaga en forma muy similar a éste. Tiene como diferencia fundamental, al producción de atipías linfoides y su muy largo período de incubación. Se lo encuentra en casi todo el mundo, pero su origen es el sur del Japón, si bien es endémico en la costa Americana del Pacífico, donde produce el cuadro neurológico mencionado anteriormente
Subject(s)
Human T-lymphotropic virus 1/pathogenicity , HTLV-I Infections/epidemiology , HTLV-I Infections/microbiology , Leukemia-Lymphoma, Adult T-Cell/epidemiology , Leukemia-Lymphoma, Adult T-Cell/microbiology , Paraparesis, Tropical Spastic/epidemiology , Paraparesis, Tropical Spastic/microbiology , ArgentinaSubject(s)
Adolescent , Adult , Middle Aged , Humans , Male , Female , Retroviridae/isolation & purification , Nervous System Diseases/epidemiology , Paraparesis, Tropical Spastic/epidemiology , Enzyme-Linked Immunosorbent Assay , Human T-lymphotropic virus 1/isolation & purification , HTLV-I Antibodies/analysis , Blotting, Western , Nervous System Diseases/physiopathology , Nervous System Diseases/immunology , Nervous System Diseases/microbiology , Paraparesis, Tropical Spastic/physiopathology , Paraparesis, Tropical Spastic/immunology , Paraparesis, Tropical Spastic/microbiologyABSTRACT
Se revisa la informacion sobre la paraparesia espastica del Pacifico (PEP) y la paraparesia espastica tropical (PET). Dada la alta positividad de anticuerpos contra el virus HTVL-I en pacientes con PEP de Colombia y con PET de Jamaica, Martinica y Japon se considera que el virus HLTV-I seria el agente causal de la enfermedad. Se revisan la epidemiologia y la informacion reciente sobre el virus HTVL-I. Se informan los resultados de un estudio de casos y controles realizado en Tumaco (costa pacifica de Colombia), que indican una relacion causal entre el virus HTVL-I y la PEP. Se hacen algunas consideraciones terapeuticas y se propone el nombre de mieloneuropatia asociada con retrovirus (MAR) a esta entidad clinica de distribucion mundial