1.
Indian J Physiol Pharmacol
;
1984 Jul-Sep; 28(3): 219-22
Article
in English
| IMSEAR
| ID: sea-107462
ABSTRACT
Rats pretreated with prostaglandin synthesis stimulators, phenoxymethyl penicillin (2, 4 and 8 mg/kg, ip) and levamisole (2.5, 5 and 10 mg/kg, ip) showed a dose related potentiation of catalepsy after subthreshold doses of haloperidol (0.1 mg/kg, ip). Pretreatment with prostaglandin synthesis inhibitors paracetamol and indomethacin exhibited significant inhibition of catalepsy at lower doses (2.5, 6, 10 and 15 mg/kg, ip). However, this antagonism was paradoxically less at higher dose levels (20 and 30 mg/kg, ip). The data suggest neuromodulatory contribution of prostaglandins in neuroleptic-induced catalepsy.
Subject(s)
Acetaminophen/pharmacology , Animals , Catalepsy/chemically induced , Haloperidol , Humans , Indomethacin/pharmacology , Levamisole/pharmacology , Male , Penicillin V/pharmacology , Prostaglandins/biosynthesis , Rats
2.
Hindustan Antibiot Bull
;
1972 May; 14(1): 184-90
Article
in English
| IMSEAR
| ID: sea-2562