Metastatic penile carcinomas : a study of nine cases and review of the literature

Objective: Primary penile carcinoma is one of the rarest male genital tract tumors in Turkey; because circumcision is performed routinely. In general; metastatic carcinoma of the penis is the second most common penile tumor. Despite the fact that the penis is rarely affected by metastases; there have been 319 cases reported in the literature. This study was carried out to throw light on the main characteristics of the metastatic disease. Patients and Methods: Nine patients aged between 32 and 68 years (median 62.9 years) with metastatic tumors of the penis were the subject of this study. The clinical history of the cases was reviewed; and the patients' data were recorded including location; histology of the primary tumor; presence and location of other metastases; clinical findings; treatment and outcome. The microscopic preparations from both the primary tumor and the penile metastases were reviewed in our pathology department to confirm that the penile lesions showed the same histomorphological characteristics as the primary tumor. Results: The primary tumors were located in the genitourinary system in 7 / 9 patients(transitional cell carcinoma of the bladder); while in the remaining two patients the primary site was the lung (squamous cell carcinoma) and the bone marrow (lymphoblastic leukemia); respectively. Percutaneous needle aspiration cytology was performed in all cases and incisional biopsy in one case for diagnosis. Total penectomy was the treatment of choice in 7 cases and bilateral cavernotomy in the leukemia case. No treatment was given to one patient because of multiple metastases in other organs. Survival after treatment lasted from 4 months to 62 months; the longest survival (5 years) was found in the leukemia case. Conclusion: Metastatic penile carcinomas are relatively rare and present a challenging problem. Total penectomy and local excision of solitary nodules or distal penile involvement still represent the treatment of choice. However; because of the association of a penile metastatic lesion with advanced disease; survival rates are limited; and the majority of the patients die within one year

Cancer de pene experiencia cooperativa en Santa Cruz / Cancer of penis cooperative experience in Santa Cruz

Se presenta la experiencia personal de los autores, que trabajan en tres centros hospitalario grandes de nuestra ciudad (Hosp. Oncologico y C.N.S., hOSP. Japones) en un numero de 85 casos de Cancer de Pene. Realizandose un analisis de presentacion de acuerdo a la edad, tiempo transcurrido desde la aparicion del tumor hasta la primera consulta, sus diferentes localizaciones, el astadiamento y el tipo histologico de los tumores. Finalmente se realiza un analisis de los resultados de acuerdo a los distintos tratamiento afectuados. Se hacen las consideraciones epidemiologicas para neustro medio y se trata de esbozar un protocolo de tratamiento, para aplicar en lo sucesivo.

Carcinoma epidermoide del pene en un adolescente: informe de un caso / Carcinoma of the penis in adolescents: A report case

Se informa de un paciente masculino de 15 años de edad, no circuncidado, con deficiente higiene personal y sin antecedentes de vida sexual activa, con un tumor en el pene. La biopsia confirmó carcinoma bien diferenciado, invasor con metástasis a los ganglios linfáticos de la región inguinal. En el tejido de la biopsia se realizó la búsqueda de ADN del virus del papiloma humano tipos 8, 11, 12 y 16 por la reacción en cadena de la polimerasa, la cual fue negativa. Al paciente se le propuso penectomía la que rechazó. Se dio tratamiento paliativo con quimioterapia y radioterapia. Posteriormente presento necrosis total del pene con amputación espontánea. Este es el primer caso de carcinoma epidermoide del pene en un adolescente informado en la literatura latinoamericana