Effect of cimetidine, ranitidine and tiotidine on histamine stimulated gastric acid secretion in intact rats under local conditions

Antisecretory effects of cimetidine, ranitidine and tiotidine were studied on histamine-stimulated gastric Secretion in pylorus ligated intact rats at the dose levels. The data obtained showed that the efficacy of these drugs in reducing the volume of gastric juice was in the order of ranitidine> tiotidine> cimetidine. However, their acid reducing capacities were observed to be in the order of ranitidine> cimetidine> tiotidine in the checked doses. Thus, the data suggests that ranitidine is the most effective antiulcer drug of all the three tested H2-bloking agents