Incidencia y factores asociados en la recurrencia de sangrado ulceroso post inyectoterapia con adrenalina / Incidence and associated factors in ulcer bleeding recurrence post inyectotherapy with adrenalin

Objetivo: Determinar la incidencia y los factores asociados en la recurrencia de sangrado post terapia endoscópica con inyección de adrenalina en pacientes con sangrado ulceroso de un hospital de referencia nacional. Materiales y Métodos: Diseño analítico longitudinal. Se revisaron historias clínicas de pacientes con diagnóstico de Hemorragia Digestiva Alta y con tratamiento endoscópico de inyección con adrenalina entre el 2005 y 2011 en el Hospital Nacional Daniel Alcides Carrión, Perú. Se midieron las variables resangrado ulceroso, factores de riesgo pre-endoscópicos y endoscópicos. Los datos obtenidos fueron sometidos a un análisis bivariado (X2, Test exacto de Fisher y RR) y a un análisis multivariado. Resultados: Se incluyeron 111 pacientes. La incidencia de resangrado fue de 20,7%. El análisis multivariado reveló que el sangrado activo (p=0,002) y el uso de anticoagulantes (p=0,035) fueron variables asociadas con resangrado. Conclusión: La incidencia de resangrado fue de 20,7% y los factores asociados fueron Sangrado Activo y el uso de anticoagulantes.

Aim: to determine the incidence and associated factors with Upper Gastrointestinal bleeding after injection therapy with adrenaline in a general hospital. Methods: Study design: longitudinal and analytic. Clinical records of patients with Upper Gastrointestinal bleeding who received injection therapy with adrenalin during 2005 and 2011 in Daniel Alcides Carrion Hospital, Peru were reviewed. Rebleeding and pre-endoscopic and endoscopic associated factors were sought. A bivariate (Chi Square, Fisher Exact test and RR) and multivariate analysis were performed. Results: A total of 111 patients were included. Rebleeding rate was 20.7%. Multivariate analysis showed active bleeding (p=0.002) and anticoagulant drugs (p=0.035) were associated with rebleeding. Conclusion: Rebleeding rate was 20,7% and active bleeding as well as anticoagulant drugs use were associated factors.

Peptic ulcer bleeding: is Helicobacter pylori a risk factor in an endemic area?

BACKGROUND/OBJECTIVE: A high prevalence of Helicobacter pylori infection has been reported in Iran. Although the importance of H. pylori in the induction of peptic ulcer disease is clearly defined, only few studies have addressed its role in bleeding from peptic ulcers. We evaluated the role of H. pylori in peptic ulcer bleeding. METHODS: Patients with acute peptic ulcer bleeding (PUB) and those with peptic ulcer disease without bleeding ('controls') were enrolled. Upper GI endoscopy and rapid urease test were performed in both groups. Histological study for detection of H. pylori was performed in patients with active bleeding, if RUT was negative. Other variables evaluated included sex, age, smoking, previous history of bleeding, non-steroidal anti-inflammatory drugs use, ulcer size, ulcer location, and duration of acid-peptic disease. Multivariate logistic regression analysis was performed to identify independent risk factors. RESULTS: 161 patients with PUB and 287 control patients were enrolled. H. pylori infection was seen more frequently in patients with duodenal ulcer than gastric ulcer (88.9% vs. 60.5%, p< 0.001). Univariate analysis showed that patients with PUB were more often male, older in age, used NSAID, had history of PUB in the past, had ulcer located in the stomach and not in the duodenum, and more often had large ulcer (>1 cm). Logistic regression analysis showed that H. pylori infection was protective in PUB after controlling for confounders (OR 0.41, 95% CI 0.21-0.79), when ulcer location was not entered in the model. A second model including ulcer location (to test for a residual effect) showed that H. pylori infection was not a significant risk factor in PUB (OR 0.61, 95% CI 0.30-1.24). CONCLUSIONS: H. pylori may not be an independent factor in bleeding from peptic ulcers. The lower frequency of this infection in these patients can be described by the higher frequency of bleeding from gastric ulcers, which are less H. pylori related compared with duodenal ulcer.

Clinical and endoscopic aspects in the evolution of patients with bleeding peptic ulcer: a cohort study

BACKGROUND: Bleeding ulcers are a major problem in public health and represent approximately half of all the cases of upper gastrointestinal hemorrhage in the United States. This study aims to determine the prognostic value of factors such as clinical history, laboratory and endoscopic findings in the occurrence of new episodes of bleeding in patients who have upper gastrointestinal hemorrhage caused by gastric or duodenal peptic ulcer. METHODS: A cohort study with 94 patients was designed to investigate prognostic factors to the occurrence of new episodes of bleeding. RESULTS: From the 94 patients studied, 88 did not present a new bleeding episode in the 7 days following hospital admission. The incidence of rebleeding was significantly higher in those patients with hemoglobin < 6 g/dL at the admission (P = 0.03, RR = 6.2). The localization of the ulcers in bulb was positively associated to rebleeding (P = 0.003). The rebleeding group needed a greater number of units transfunded (P = 0.03) and the time of hospitalization was longer than the time of the hemostasia group (P = 0.0349). CONCLUSIONS: The identification of patients with risk of death by bleeding peptic ulcer remains as a challenge, once few factors are capable of predicting the severity of the evolution. The identification of such factors will alow the choice of the better therapeutic conduct improving the diagnosis and decreasing the rate of rebleeding and the mortality

Ulcera péptica con hemorragia. Análisis de egresos hospitalarios / Peptic ulcer with hemorrhage. An analysis of hospital discharges

Antecedentes. La UG y UD presentan hemorragia en 25 por ciento de los pacientes es una de las principales causas de hospitalización. Objetivo. Determinar la prevalencia de UP con HTDA, por sexo y edad, cuantificar su estancia hospitalaria, su asociación con factores de riesgo y su variación estacional. Método. Se analizaron los egresos hospitalarios durante el periodo de 1991 a 1997; se determinó la tasa de prevalencia ajustada por sexo y edad por 1000 egresos. Se cuantificó su estancia hospitalaria y costo por pacientes. Se investigaron las manifestaciones de hemorragia y la presencia de tabaquismo, etilismo e ingestión de AINE's. Análisis estadístico. Chi cuadrada y t de Student. Resultados. La tasa de prevalencia anual fue de 46.8/1000 egresos hospitalarios. Predominó en la sexta y octava décadas de la vida, con predominio en el sexo femenino (PNS) y durante los meses de mayo, junio y noviembre. La estancia hospitalaria promedio fue de 4.2 días y el costo diario fue de $1,520.00. En 275 pacientes con HTDA fueron del sexo masculino 66 por ciento y la edad promedio de 57 años, la frecuencia de factores de riesgo como tabaquismo (52 por ciento), etilismo (40 por ciento), AINE's (44 por ciento), se observaron con más frecuencia en los pacientes del IMSS (p<0.05). Melena y hematemesis se encontraron en 64 por ciento y 36 por ciento de los casos respectivamente. La UG (41 por ciento) fue más frecuente que la UD (40 por ciento) (PNS). Conclusiones. Se observó una tasa de 46.8/1000 egresos, predominó en mayores de 60 años y en sexo masculino. La UG fue más frecuente y el tabaquismo se asoció en la mayoría de los casos de UP y HTDA

Factores asociados a sangrado gastrointestinal alto - Hospital Padre Billini, 1995-1997 / Factors associated with upper gastrointestinal bleeding \"Padre Billini\" Hospital 1995-1997

Se realizó un estudio retrospectivo con fines de investigar factores asociados a sangrado gastrointestinal alto durante el período abril 1995 a abril 1997 en el Hospital Padre Billini, de donde 35 casos el 60// correspondió al sexo masculino, los grupos de edades más afectado fue de 29-40, 41-52 y 53-64 años para un 14.3// respectivamente, el grupo sanguíneo más afectado fue el grupo ORH+ para un 42.9//, el 63// de los pacientes tenían algún tipo de hábitos tóxicos, el 31.1// refirió antecedentes de gastritis y 28.9// de úlcera péptica, el 14.3// tuvo historia de transfusiones y 22.9// antecedentes, transfusiones

Características clínicas de pacientes con úlceras pépticas múltiples o gigantes / Giant or multiple peptic ulcers

The incidence and clinical characteristics of multiple or giant ulcers (over 20 mm for duodenal ulcer or 25 mm for gastric ulcer) was evaluated among 1434 patients with peptic ulcers. For gastric ulcers, multiple and giant lesions were found in 27% and 14% of patients respectively. Among duodenal ulcers the corresponding figure were 16% and 2.4%. patients with triple gastric ulcers have a greater incidence of massive bleeding. Patients with triple duodenal ulc4ers are older, have more massive and have a greater incidence of gastric retention and hypersecretion and hypersecretion when compared to patients with single or double duodenal ulcers. Giant gastric ulcer was associated to a shorter history and more massive bleeding; giant duodenal ulcer was associated to older age, more massive bleeding and gastric retention, when compared to patients with common size ulcers