ABSTRACT
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive lethal malignancy, characterized by late diagnosis, aggressive growth, and therapy resistance, leading to a poor overall prognosis. Emerging evidence shows that the peripheral nerve is an important non-tumor component in the tumor microenvironment that regulates tumor growth and immune escape. The crosstalk between the neuronal system and PDAC has become a hot research topic that may provide novel mechanisms underlying tumor progression and further uncover promising therapeutic targets. In this review, we highlight the mechanisms of perineural invasion and the role of various types of tumor innervation in the progression of PDAC, summarize the potential signaling pathways modulating the neuronal-cancer interaction, and discuss the current and future therapeutic possibilities for this condition.
Subject(s)
Humans , Carcinoma, Pancreatic Ductal/pathology , Pancreatic Neoplasms/therapy , Signal Transduction , Peripheral Nerves/metabolism , Tumor MicroenvironmentABSTRACT
El presente papel tiene como objetivo estudiar y analizar los resultados obtenidos en la reparación de nervios periféricos, a largo plazo, en el presente caso, 5 años después de la reparación del tronco nervioso seccionado, con técnicas de sutura convencional y la utilización de la cola de fibrina como sutura del mismo efecto. Observando resultados muy similares en ambos grupos, con dificultad para una fuerza muscular buena (hecho frecuente en estas lesiones), pero con una recuperación sensitiva aceptable