To study therapeutic effect and benefit on quality of life in scabies patients

To determine the quality of life by using 5% permethrin cream in scabies patients. Scabies is a contagious, itchy ectoparasitic infection caused by sarcoptes scabiei mite. It is a common public health problem with an estimated global prevalence of 300 to 400 million cases. They increases day by day due to resistance/ recurrence and largely effect the quality of life. 5% permethrin is one of the effective treatment of scabies it is highly effective, well tolerated, poorly absorbed and rapidly metabolized by skin. Open Label Clinical Trail study approved by ethics committee of Jinnah Postgraduate Medical Centre, Karachi. This study was conducted in Basic Medical Sciences Institute with Collaboration of Dermatology Department of JPMC, Karachi from 1st Dec 2010 to 30th Jan. 2011. This study sample involved 65 clinically diagnosed scabies patients who were treated with 5% permethrin cream. Clinical data was collected by using questionnaire. Patients were divided into three age groups and given two applications of permethrin cream on first and 15 day. Follow ups was done on Day 3, Day 15 and Day 30 and there quality of life assessed using dermatological life quality index on day 0 and 30. It was found that quality of life in scabies patients was low and treatment with permethrin cream clinically improved the symptoms of patients and their quality of life significantly. Scabies has a social stigma and the quality of life of patient get effected because of night itching and lack of sleep which improves significantly following proper local therapy

Aerial and tidal transport of mosquito control pesticides into the Florida Keys National Marine Sanctuary

This project was undertaken as the initial monitoring program to determine if mosquito adulticides applied along the Florida Keys cause adverse ecological effects in the Florida Keys National Marine Sanctuary (FKNMS). The study monitored the distribution and persistence of two mosquito adulticides, permethrin and dibrom (naled), during three separate routine applications by the Florida Keys Mosquito Control District. The approach was to determine if toxic concentrations of the pesticides entered the FKNMS by aerial drift or tidal transport. The amount of pesticide entering the FKNMS by way of aerial drift was monitored by collection on glass fiber filter pads, set on floats in a grid pattern on either side of the FKNMS. Permethrin was recovered from filter pads on the leeward side for each of the three applications, ranging from 0.5 to 50.1 microg/m(2) throughout the study. Tidal current transport was monitored by collection of surface and subsurface water samples at each grid site. Tidal transport of naled and dichlorvos (naled degradation product) was apparent in the adjacent waters of the FKNMS. These compounds were detected in subsurface, offshore water at 0.1 to 0.6 microg/1, 14 hr after application. Permethrin was not detected in offshore water samples; however, concentrations ranging from 5.1 to 9.4 microg/l were found in surface water from the canal system adjacent to the application route. Comparison of the observed environmental concentrations with toxicity data (permethrin LC-50, 96 hr for Mysidopsis bahia = 0.02 microg/l) indicated a potential hazard to marine invertebrates in the canals with possible tidal transport to other areas

Evaluation à court et moyen terme de l'effet de la permethrine sur la faune icthtyologique du fleuve Sassanda (Côte d'Ivoire)

Convention IET/OMS