ABSTRACT
Introducción.La medicina del siglo XXI será un punto de fusión de numerosas nuevas tecnologías. Surgirán transformaciones en los paradigmas de la atención médica. Objetivo: Ofrecer una visión de lo que podría ser la atención médica futura. Material y Métodos: Se revisa en la literatura médica las ultimas y nuevas herramientas tecnológicas al servicio de la Medicina, sus posibles transformaciones y aplicación futura a través de la exploración en las principales bases de datos indexadas en los últimos 7 años, que originarán un cambio en el pensamiento científico y una visión predictiva en la atención médica a nivel mundial que realizaran reflexiones sobre enfoques médicos que origina la medicina traslacional. Se analiza el papel de la nanotecnología en la farmacología futurista, así como la genética y robótica, y se establecen comparaciones entre la cantidad de investigaciones por países y el estado actual en la América Latina y cómo influirán los nuevos adelantos científicos en la bioética lo que pudiera dar origen al transhumanismo. Resultados: El influjo de las nuevas tecnologías está ligado con el desarrollo económico y social, por lo que su aplicación no será equitativa, existiendo una diferencia importante en la formulación de patentes, investigaciones indexadas y citaciones entre países desarrollados y subdesarrollados, donde ningún país latinoamericano se encuentra entre los primeros 10 lugares del ranking mundial. Conclusiones: La tecnología actual le da solución a algunos problemas, pero no ha sido capaz de dominar muchas enfermedades. La utilización de la nanotecnología, la genética y la robótica provocarán cambios en los paradigmas de enfrentamiento a las enfermedades. Pudieran ocasionar deshumanización y problemas bioéticos(AU)
Introduction: Medicine in the 21st century will be a fusion point of numerous new technologies. Changes in the paradigms of medical attention will emerge. Objective:To present a view of what future medical attention could be. Material and methods:A review of the last and new technological tools at the service of Medicine is made, and their possible transformations and future implementation are studied through the search of the main databases of the data indexed during the last seven years, which will make a change in the scientific thought and a predictive view of the medical attention worldwide, and make reflections on the medical approaches that arise from translational medicine. The role of nanotechnology in the futuristic pharmacology is analyzed, as well as genetics and robotics; and comparisons are made regarding the amount of research by countries and the current condition in Latin America, and the way the new scientific innovations will influence in the Bioethics, which could give rise to transhumanism. Results:The influence of the new technologies is linked to the economic and social development. Therefore, its implementation will not be equitable, existing an important difference in establishment of patents, indexed research, and quotations between developed and underdeveloped countries, where no Latin American country is among the 10 first places in the world ranking. Conclusions:Current technology gives solution to some problems, but it has not been able to be acquainted with many diseases. The use of nanotechnology, genetics, and robotics will provoke changes in the confrontation paradigms of diseases, which could cause dehumanization and bioethical issues(AU)
Subject(s)
Humans , Pharmacology, Clinical/trends , Access to Essential Medicines and Health Technologies , Holistic Health/education , Biomedical Technology/methods , Nanotechnology/trendsABSTRACT
Therapeutic drug monitoring, a comparatively new investigational procedure in clinical pharmacology, is considered very beneficial to epilepsy patients though it increase the health care cost. Aim of this study was to determine the pattern of use of antiepileptic drug level monitoring over the last 7 years in our tertiary care centre and to critically comment on its utility. Retrospective data audit of archived data from 1998 to 2004 and age, sex, estimated levels of phenytoin, carbamazepine and phenobarbitone by HPLC were noted down, tabulated and compared. Chi square test was used for analysis. Three thousand five jundred thirty four blood samples of patients requesting for 4213 estimations of phenytoin, phenobarbitone or carbamazepine were received. Among the obtained samples, 44.0% (1058) were of children, 68.0% (2402) were of males, 0.6% (22) patients were getting 3 and 18.0% (635) getting 2, antiepileptic medications. 13.0% (546) samples showed level in the toxic range and 39.0% (1653) in lower range. There was increasing demand observed for estimation of antiepileptic drugs, over the 7 years. The number of abnormal values of phenytoin, phenobarbitone and carbamazepine did not show any significant difference over the years. The pattern was similar to that observed in other countries.
Subject(s)
Anticonvulsants/blood , Carbamazepine/blood , Drug Monitoring/statistics & numerical data , Epilepsy/drug therapy , Humans , India , Pharmacology, Clinical/trends , Pharmacy Service, Hospital , Phenobarbital/blood , Phenytoin/blood , Retrospective StudiesABSTRACT
Se presenta una síntesis del desarrollo de los antimicrobianos, abarcando la antigüedad y los tiempos modernos, incluyendo la era pre-antibiótica, el periodo del explosivo desarrollo de antibióticos y el futuro en el cual se plantea los riesgos del incremento de la resistencia y el menor interés de la industria en invertir en la investigación de nuevos compuestos.
Subject(s)
Humans , Anti-Bacterial Agents/history , Pharmacology, Clinical/trends , Drug Resistance, MicrobialABSTRACT
As interações medicamentosas são uma realidade crescente na prática médica. No entanto, a maioria das interações de drogas, habitualmente empregadas na terapia clínica diária, não tem lastro experimental - fato que torna imprevisível o seu resultado, principalmente em termos de possíveis efeitos colaterais. O trabalho procura enfatizar o conhecimento elementar sobre o assunto, destacando os seus aspectos farmacológicos realmente básicos
Subject(s)
Drug Antagonism , Drug Incompatibility , Drug Synergism , Pharmacology, Clinical/trends , Homeopathic Prescription , Biopharmaceutics/trends , Technology, Pharmaceutical/trendsABSTRACT
No abstract available.