ABSTRACT
In New Zealand rabbits a single intravenous injection of streptozotocin (STZ 65 mg/kg) elevated the levels of blood sugar to 340 mg percent, which was associated with glycolysis, ureamia, hypercholesterolemia, hypertriglyceridemia and loss of body weight. Oral administration of jambolan seed (1 g/kg) in casein diet significantly lowered the elevated postmeal (1 1/2 hr after) values of blood sugar, cholesterol, FFA and triglyceride down to levels comparable to phenformin. Jambolan seed treatment failed to check ureamia. Weight loss was checked by phenformin and jambolan seed but the gain was not equivalent to that recorded in nondiabetic control. Like phenformin, jambolan seed too failed to control glycogenolysis in STZ-induced diabetes.
Subject(s)
Animals , Blood Glucose/metabolism , Body Weight/drug effects , Diabetes Mellitus, Experimental/blood , Diet , Lipids/blood , Male , Phenformin/pharmacology , Plants, Medicinal , Rabbits , Urea/bloodSubject(s)
Adult , Cholesterol/blood , Diabetes Mellitus/blood , Female , Humans , Male , Middle Aged , Phenformin/pharmacology , Triglycerides/bloodABSTRACT
Hypoglycaemic fractions of A. cepa Linn (onion) have been separated. After 7 days treatment, the more active hypoglycaemic fraction was about half as active as Phenformin in lowering the fasting blood sugar of alloxan-diabetic rabbits. Oral administration of the hypoglycaemic fraction to alloxan-diabetic rabbits improved their glucose tolerance also. Juice expressed residue of onion, when fed to diabetic patients along with their food, controlled the hyperglycaemia effectively.