Nuevas drogas en el tratamiento de la obesidad y el sobrepeso / New drugs for the treatment of obesity and overweight / Novas drogas no tratamento da Obesidade e Sobrepeso

a obesidad y el sobrepeso se asocian con un mayor riesgo de mortalidad global y de padecer numerosas patologías crónicas, y son muy difíciles de tratar. Es por esto que la implementación de medidas farmacológicas seguras y eficaces reviste una suprema importancia. La lorcaserina y la combinación fentermina/topiramato son nuevas opciones farmacológicas aprobadas en el año 2012 por la FDA (Food and Drugs Administration de los Estados Unidos), a pesar de su compleja forma de administración, y los requerimientos de un programa de entrenamiento y de monitoreo de postmarketing. En el artículo se describen las nuevas drogas aprobadas, sus mecanismos de acción, efectos adversos, características farmacocinéticas su uso en situaciones especiales, y los inconvenientes con las drogas previamente aprobadas y que fueron retiradas del mercado.Palabras clave: obesidad, sobrepeso, topiramato, fentermina, lorcaserin

besity and overweight are associated with an increased risk of overall mortality and the development of many chronic diseases, and they are very difficult to treat. That is why the implementation of safe and effective pharmacological measures is of paramount importance. Lorcaserin and the combination of phentermine/topiramate are two new pharmacological therapies for chronic weight management. They were approved in 2012 by the U.S. Food and Drug Administration, despite concerns over its complex form of administration and the requirement of a training and post-marketing surveillance program.This article describes newly approved drugs, their mechanisms of action, side effects, pharmacokinetics, and their use in special situations, along with the drawbacks of previously approved drugs that were withdrawn from the market.

A obesidade e o sobrepeso são associados a um maiorrisco de mortalidade global e ao padecimento de numerosaspatologias crônicas, e são muito difícies de tratar. É poristo que a implementação de medidas farmaco lógicasseguras e eficazes possui uma suprema importância.A lorcaserina e a combinação fentemina/topiramato sãonovas opções farmacológicas aprovadas no ano 2012pela FDA (Food and Drugs Administration de los EstadosUnidos), apesar da sua complexa forma de administração, eos requerimentos de um programa de treinamento e demonitoramento de postmarketing. No artigo estão descritas as novas drogas aprova das,seus mecanismos de ação, efeitos adversos, característicasfarmacocinéticas, seu uso em situações especiais, e osinconvenientes com as drogas previamente aprovadas eque foram retiradas do mercado.

RE: Pulmonary Hypertension Associated with Use of Phentermine?

No abstract available.

Pulmonary Hypertension Associated with Use of Phentermine

Weight-control drugs (known as anorexigens) such as fenfluramine have been linked with pulmonary hypertension in previous reports. In our case, a 29 year old woman was admitted for shortness of breath and was diagnosed with pulmonary hypertension. Three months ago, she had been taking phentermine for five weeks. Other factors that might have contributed to the development of pulmonary hypertension were excluded. With treatment, her symptoms improved. This is the first case that can suggest a possible connection between phenermine single medication with pulmonary hypertension. Phentermine has been considered a relatively safe drug to treat obesity, and further investigation is needed to decide the safety and dosage of phentermine.