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Arq. neuropsiquiatr ; 75(11): 825-826, Nov. 2017. graf
Article in English | LILACS | ID: biblio-888270

ABSTRACT

ABSTRACT Mary Broadfoot Walker was a Scottish physician who, in 1935, described in great detail the effect of an anticholinesterase drug (physostigmine) on the signs and symptoms of myasthenia gravis. An original five-minutes movie is available online and the skepticism of her contemporary British medical doctors is understandable when the drastic effect of the treatment is shown in this movie. What Mary Walker taught us, more than eight decades ago, about myasthenia gravis continues to be the basis of a pharmacological diagnostic test and treatment of this disease.


RESUMO Mary Broadfoot Walker foi uma médica escocesa que em 1935 descreveu em grande detalhe o efeito de uma droga anticolinesterásica (fisostigmina) nos sinais e sintomas da myasthenia gravis. Um filme original com cinco minutos de duração está disponível online e a reação cética dos colegas médicos contemporâneos de Mary é compreensível dado o drástico efeito terapêutico mostrado neste filme. O que Mary Walker nos ensinou mais de oito décadas atrás continua a ser a base de um teste diagnóstico farmacológico e do tratamento da myasthenia gravis.


Subject(s)
History, 20th Century , Physostigmine/history , Cholinesterase Inhibitors/history , Myasthenia Gravis/history , Physostigmine/therapeutic use , Scotland , Video Recording , Cholinesterase Inhibitors/therapeutic use , Myasthenia Gravis/drug therapy
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