Subject(s)
Antibodies/analysis , Anticoagulants/adverse effects , Antithrombins/therapeutic use , Benzimidazoles/therapeutic use , Chondroitin Sulfates/therapeutic use , Dermatan Sulfate/therapeutic use , Fibrinolytic Agents/therapeutic use , Heparin/adverse effects , Heparin/immunology , Heparitin Sulfate/therapeutic use , Hirudins , Peptide Fragments/therapeutic use , Pipecolic Acids/therapeutic use , Platelet Aggregation Inhibitors/therapeutic use , Polysaccharides/therapeutic use , Pyridines/therapeutic use , Recombinant Proteins/therapeutic use , Thrombin/antagonists & inhibitors , Thrombocytopenia/chemically induced , Thrombocytopenia/therapySubject(s)
Anticoagulants/therapeutic use , Antithrombins/therapeutic use , Benzimidazoles/therapeutic use , Humans , Morpholines/therapeutic use , Pipecolic Acids/therapeutic use , Pyrazoles/therapeutic use , Pyridones/therapeutic use , Thiophenes/therapeutic use , Venous Thromboembolism/prevention & control , beta-Alanine/analogs & derivatives , beta-Alanine/therapeutic useABSTRACT
The concept of neuroprotection relies on the principle that delayed neuronal injury occurs after ischemia. The phenomenon of the "ischemic cascade" has been described, and each step along this cascade provides a target for therapeutic intervention. A wide variety of drugs have been studied in humans. Ten classes of neuroprotective agents have reached phase III efficacy trials but have shown mixed results. They included calcium channel antagonists, NMDA receptor antagonists, lubeluzole, CDP-choline, the free radical scavenger tirilazad and ebselen, enlimomab, GABA agonist clomethiazole, the sodium channel antagonist fosphenytoin, magnesium, glycine site antagonist GV150526 and piracetam. Furthermore, the mechanisms that underlie the development of focal ischemic injury continue to be discovered, opening new therapeutic perspective for neuroprotection that might clinically be applicable in the future.