Clinical, hormonal and radiological features of partial Sheehan's syndrome: an Indian experience

ABSTRACT Objective The objective of this study was to describe clinical presentation, hormonal profile and imaging characteristics of 21 patients with partial Sheehan’s syndrome. Subjects and methods This prospective study was carried out over a period of six years (2008-2013). The evaluation of patients included clinical assessment, hormone estimations and contrast enhanced magnetic resonance imaging of pituitary. Results We documented preservation of gonadotroph, corticotroph and lactotroph function in 71.4, 61.9, and 9.5% of patients respectively. Conclusion To conclude some of the pituitary functions can be preserved in Sheehan’s syndrome and this has important implications from the treatment and long term morbidity point of view.

Children with clinical central diabetes insipidus at King Chulalongkorn Memorial Hospital.

OBJECTIVES: To determine the etiologies and associated endocrine disorders in children with central diabetes insipidus (DI). MATERIAL AND METHOD: The authors retrospectively reviewed the medical records of children with central DI, who were admitted at department of Pediatrics, King Chulalongkorn Memorial Hospital, between 2000 and 2004. Aims of this study were to identify the etiology of central DI in children and also described the anterior pituitary hormone insufficiencies which may occur. RESULTS: Of the total 51 patients, 27 patients were males and 24 were females. Intracranial tumors produced DI in 36 children (70.6%), but 17 of these 36 children (47.22%) had DI before surgical removal of the tumors. Fifteen patients (29.4%) had DI from non-tumor causes, which include idiopathic in 2 patients (13.5%), terminal events in 4 patients (26.8%), central nervous system (CNS) infection in 5 patients (33.3%), CNS anomalies in 2 patients (13.5%), Kabuki syndrome in 1 patient (6.6%), head injury in 1 patient (6.6%). Anterior pituitary function was evaluated in all tumor group and 8 patients of non-tumor group. In intracranial tumor group, growth hormone deficiency (GHD) was documented in 14 from 22 patients (63.6%), secondary adrenal insufficiency in 13 from 20 patients (65%), central hypothyroid in 27 from 36 patients (75%), hyperprolactinemia in 5 from 8 patients (62.5%). CONCLUSION: The most common etiology of central DI is intracranial tumor, and at least 50% of them have clinical features suggesting central DI before surgery. More than 60% have associated anterior pituitary hormone insufficiency.

TSH ultra-sensible et test a la TRH dans l'insuffisance ante-hypophysaire

In 74 patients with untreated pituitary insufficiency, the TRH- test [Ultra- Sensible TSH performed by immunoradiometric assay] has permitted to detect 48 thyreotrop deficiency. There is no correlation between basal TSH- us values and TSH reponse [TSH] under TRH; only 4 patients with pituitary hypothyroidism presented low basal TSH- us [<0.26 micro Ul/ml]. In the pituitary pathology, the TSH reponse under TRH remains indispensable for the evaluation of TSH pituitary reserves, since basal TSH- us value doesn't permit to predict the reponse TSH to TRH

Influence of pituitary on histology of Bidder's organ in castrated toad Bufo melanostictus.

Weight, number of follicles and corpora lutea of Bidder's organ increased significantly after castration of adult toad in breeding season. Removal of pituitary along with testes decreased both weight and number of follicles and corpora lutea. Administration of luteinizing hormone (LH) in castrated and hypophysectomized toad showed more or less similar result as that of control indicating that LH has an effect on the histology of Bidder's organ in the toad.