ABSTRACT
To determine the frequency of placental infarcts and its effect on fetal outcome in hypertensive primigravida mothers. This study was conducted at Obstetrics and Gynecology Department, Lady Reading Hospital Peshawar from 1[st] January 2011 to 30[th] September 2011. The sample size was 130 primigravida mothers. This study was cross sectional in which non probability consecutive sampling technique was adopted. The data was collected on predesigned proforma and was analyzed using SPSS version 17. This study included 130 primigravida mothers in age range from 19-35 years with mean age of 27.27+4.04 years. Placental infarcts were seen in 31% [n=40] patients. Sixty percent [n=24] patients had focal placental infarcts while 40% [n=16] had multifocal placental infarcts. Among fetuses whose placenta showed no infarction, 90% fetuses were live born and 10% were still-born while those fetuses whose placenta showed infarction 70% fetuses were alive and 30% fetuses were still-born. The incidence of adverse perinatal outcomes including intrauterine growth restriction and still birth is higher in hypertensive primigravida mothers with placental infarcts than in hypertensive primigravida mothers with no infarcts
Subject(s)
Humans , Female , Pregnancy , Pregnancy Complications , Morbidity , Mortality , Fetal Mortality , Placenta Diseases/blood , Infarction , Placenta/blood supply , Pre-EclampsiaABSTRACT
La presente revisión trata de la enfermedad trafoblástica gestacional haciendo referencia a los tumores de origen placentario que se derivan del tejido epitelial coriónico. Se describe la clasificación según la OMS, resaltando ls sintomatología clásica de esta patología, así como también los métodos de laboratorio más utilizados como son: La ecosonografía, La dosificación de HCG. Gamagrafía, TAC, estudios de histopatología, medición de alfa feto proteínas dosificación de calcio calmodulina y de CAMP-A quinasa, por último se revisan los esquemas terapéuticos más usados hoy en día.
Subject(s)
Humans , Female , Pregnancy , Adult , Hip Dislocation, Congenital/epidemiology , Hip Dislocation, Congenital/etiology , Neoplasms , Placenta Diseases/classification , Placenta Diseases/diagnosis , Hip Dislocation, Congenital , Hip Dislocation, Congenital/therapy , Placenta Diseases/blood , Placenta Diseases/embryology , Placenta Diseases/etiology , Placenta Diseases/genetics , Placenta Diseases/therapyABSTRACT
Two-hundred fifty-six mothers and their newborns were subjected to clinical and haematological tests for the evidence of malaria. Placentae of these were examined histopathologically for malarial parasites and malarial pigment. Forty six placentae showed scanty malarial pigment ingested by monocytes. These appearances were associated with focal syncytial necrosis and proliferation of cytotrophoblastic cells. Plasmodium falciparum was found in cord blood of six cases. The mean weight of newborns born to mothers having no evidence of malarial placental infection was 2.763 kg, while mean weight of newborns belonging to infected placentae was 2.143 kg. The difference was highly significant.
Subject(s)
Birth Weight , Female , Fetal Blood/parasitology , Humans , Infant, Low Birth Weight , Infant, Newborn , Malaria, Falciparum/blood , Male , Monocytes/pathology , Necrosis , Parity , Placenta Diseases/blood , PregnancyABSTRACT
La desnutrición temprana induce cambios metabólicos específicos sobre el sistema serotoninergico cerebral, en animales de experimentación. La síntesis de serotonina cerebral se encuentra elevada, lo que depende del incremento de su precursor que es el triptófano plasmático libre; la relación del triptófano unido a albúmina con la fracción libre, determina la disponibilidad del precursor para su paso a través de la barrera hematoencefálica. En el presente estudio reportamos los resultados del metabolismo de la serotonina periférica, en dos grupos de recién nacidos humanos con desnutrición intrauterina y sus controles normales. La fracción libre del L-triptófano fue significativamente elevada, los aminoácidos neutros apresentaron modificaciones substanciales y la fracción unida a albúmina del triptófano y las proteínas del plasma fueron significativamente menores al compararse con los recién nacidos con peso adecuado para la edad gestacional. La elevación de la fracción libre del triptófano plasmático en recién nacidos con desnutrición temprana sugiere un incremento del transporte de esta aminoácido al cerebro con un aumento de la síntesis del neurotransmisor