ABSTRACT
This work included 30 patients with SHF, 10 of them had IDDM [group A], 10 patients had NIDDM [group B] and 10 patients had SHF only [group C]. Another 10 normal persons were used as control. All patients and control groups were subjected to clinical examination and laboratory investigations including liver function tests, fasting and PP blood glucose, complete blood picture and estimation of plasma platelet factor 4 by ELISA. A statistically significant rise of PF4 was found in the diabetic groups only, also there was a positive correlation between the increase in PF4 level versus both the increase in age of the patients and the prolonged duration of DM using multiple regression test. Therefore, the diabetic effect on PF4 supersede the effect of SHF on platelet behavior