ABSTRACT
Lung cancer is a malignant tumor with high incidence rate and mortality rate in China and even the whole world, of which non-small cell lung cancer accounts for about 80%. Anaplastic lymphoma kinase (ALK) gene mutation accounts for about 5%. Alectinib, ALK-tyrosine kinase inhibitor (ALK-TKI), has great performance in clinical. The early detection and treatment of adverse drug reactions can greatly improve clinical benefits. This paper reports a patient of ALK positive non-small cell lung cancer was admited to Baotou Central Hospital in April 2020. The diagnosis and treatment was retrospectively analyzed, and the literature was reviewed. .
Subject(s)
Humans , Anaplastic Lymphoma Kinase/genetics , Antineoplastic Agents/therapeutic use , Carbazoles/therapeutic use , Carcinoma, Non-Small-Cell Lung/secondary , Lung Neoplasms/pathology , Mutation , Piperidines/therapeutic use , Pleural Neoplasms/secondary , Protein Kinase Inhibitors/therapeutic use , Retrospective Studies , Tomography, X-Ray ComputedABSTRACT
Askin tumour, a primitive neuroectodermal tumour of the thoracopulmonary region, is a rare tumour presenting in childhood. Its presentation in adults is rare. We report a case of an Askin tumour in an adult patient who presented to us with worsening breathlessness and vague chest pain. Investigations including immunohistochemistry confirmed the diagnosis of Askin tumour.
Subject(s)
Adult , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Biopsy , Bone Neoplasms/drug therapy , Bone Neoplasms/pathology , Bone Neoplasms/physiopathology , Disease Progression , Humans , Lung/pathology , Lung Neoplasms/pathology , Lymphatic Metastasis , Male , Neuroectodermal Tumors, Primitive, Peripheral/pathology , /secondary , Pleura/pathology , Pleural Neoplasms/pathology , Pleural Neoplasms/secondary , Sarcoma, Ewing/drug therapy , Sarcoma, Ewing/pathology , Sarcoma, Ewing/physiopathology , Thoracic Wall/pathology , Tomography, X-Ray Computed/methods , Treatment OutcomeABSTRACT
We describe the case of a 72-year old male with pleural effusion associated with prostate cancer. There was a previous history of tobacco smoking (pack/year: 47) and of total prostatectomy followed by external beam radiation therapy seven years previously for prostate cancer. Furthermore, he was submitted to orchiectomy plus non-steroidal anti-androgen blockage, in addition to docetaxel-based chemotherapy and prednisone. After the beginning of chemotherapy, a progressive elevation in prostate specific antigen (PSA) levels was observed. On admission, he presented with fever, weight loss, and respiratory symptoms due to a massive right pleural effusion. Fluid samples obtained by needle aspiration showed haemorrhagic exudates without malignant cells. Pleural metastasis were detected by thorax imaging studies, and biopsy samples revealed prostate adenocarcinoma as the origin of his pleural effusion. Pleural fluid was drained and talc pleurodesis was performed. This report aims to describe the occurrence of massive pleural effusion due to metastasis of prostate cancer, and emphasizes the role of pleural biopsy with immunohistochemical studies to characterize this diagnosis.
Se describe un hombre de 72 años con efusión pleural asociada con cáncer de próstata. Había antecedentes de tabaquismo (47 paquetes por año) así como una historia de prostatectomía radical, seguida por terapia de radiación externa, siete años antes. Además, se le sometió a orquiectomía junto con bloqueo antiandrogénico no esteroideo, además de quimioterapia a base de docetaxel y prednisona. Después de iniciada la quimioterapia, se observó una elevación progresiva en los niveles de PSA. En el momento del ingreso, el paciente presentaba fiebre, pérdida de peso, y síntomas respiratorios debidos a una efusión pleural derecha voluminosa. Las muestras de fluido obtenidas mediante punción aspirativa con aguja fina, mostraron exudados hemorrágicos sin células malignas. Se detectaron implantes pleurales con los estudios imaginológicos del tórax, y las muestras de la biopsia revelaron que el origen de su efusión pleural, era un adenocarcinoma de la próstata. Se drenó el fluido pleural, y se procedió a practicar una pleurodesis con talco. Este reporte tiene por objetivo describir la ocurrencia de la efusión pleural masiva debido a la metástasis del cáncer de la próstata, y enfatiza el papel que desempeña la biopsia pleural junto a los estudios inmunohistoquímicos a la hora de caracterizar este diagnóstico.
Subject(s)
Aged , Humans , Male , Pleural Effusion/pathology , Pleural Neoplasms/secondary , Prostatic Neoplasms/pathology , Biopsy , Diagnosis, Differential , Drainage , Immunohistochemistry , Pleural Effusion/diagnosis , Pleural Effusion/therapy , Pleural Neoplasms/diagnosis , Pleural Neoplasms/therapy , Pleurodesis , Prostate-Specific Antigen/blood , Prostatic Neoplasms/therapy , Radiography, ThoracicABSTRACT
Adenoid cystic carcinoma, an uncommon malignant salivary gland neoplasm, is known for its long clinical course, indolent growth, local recurrence and late distant metastasis. We report an unusual case of adenoid cystic carcinoma of the palate in a 64-year-old woman, undiagnosed for more than 15 years, who presented as malignant pleural effusion.
Subject(s)
Carcinoma, Adenoid Cystic/diagnosis , Carcinoma, Adenoid Cystic/pathology , Carcinoma, Adenoid Cystic/secondary , Female , Humans , Middle Aged , Palatal Neoplasms/diagnosis , Palatal Neoplasms/pathology , Pleural Effusion, Malignant/etiology , Pleural Neoplasms/pathology , Pleural Neoplasms/diagnostic imaging , Pleural Neoplasms/secondaryABSTRACT
O tumor neuroectodérmico primitivo é uma neoplasia com diferenciação neural de comportamento invasivo que origina metástases para diversos órgãos. Relatamos um caso de tumor neuroectodérmico primitivo primário em axila com metástases para pulmão, pleura, osso, músculo ilíaco e medula óssea. Enfatizamos o achado incomum da análise citológica do líquido pleural.
Primitive neuroectodermal tumor is an invasive neoplasm with neuronal differentiation, which frequently results in metastasis in various organs. We report the case of a patient with primitive neuroectodermal tumor whose primary site was the axilla. The patient presented with metastases in the lung, pleura, bone, iliac muscle and bone marrow. We highlight the uncommon finding in the pleural fluid cytology.
Subject(s)
Adult , Humans , Male , Neuroectodermal Tumors, Primitive/pathology , Pleural Effusion, Malignant/diagnosis , Soft Tissue Neoplasms/pathology , Axilla , Biopsy , Bone Neoplasms/secondary , Neoplasm Recurrence, Local/therapy , Neuroectodermal Tumors, Primitive/secondary , Neuroectodermal Tumors, Primitive/therapy , Pleural Neoplasms/secondary , Soft Tissue Neoplasms/therapyABSTRACT
A 58-year-old, human immunodeficiency virus (HIV) negative, male farmer presented with a right-sided hemorrhagic, exudative, eosinophilic, rapidly reaccumulating pleural effusion. Pleural biopsy revealed secondary deposits from a squamous cell carcinoma. Wet mount film of pleural fluid unexpectedly showed filariform larvae of Strongyloides stercoralis. Our observation suggests that strongyloidiasis should be considered as the etiological cause for pleural effusion of obscure etiology. The threshold for suspicion should be high if the pleural effusion is exudative and eosinophil rich.
Subject(s)
Animals , Carcinoma, Squamous Cell/secondary , Eosinophilia/parasitology , HIV Seronegativity , Humans , Male , Middle Aged , Pleural Effusion, Malignant/parasitology , Pleural Neoplasms/secondary , Strongyloides stercoralis/isolation & purification , Strongyloidiasis/diagnosisABSTRACT
Os autores relatam um caso de coriocarcinoma metastático para a pleura, com invasäo pulmonar. Tratava-se de uma mulher de 27 anos de idade, cujos primeiros sintomas foram dispnéia leve e dor tipo pleurítica, apresentando PPD forte reator. A radiografia de tórax mostrava velamento do hemitórax direito, com desvio contralateral do mediastino. A tomografia computadorizada do tórax demonstrava volumosa massa pleural hipodensa, ocupando todo o hemitórax direito, determinando colapso do pulmäo direito e confirmando o desvio do mediastino, sem plano de clivagem definido com o fígado. A paciente foi submetida a uma toracotomia, sendo feita a exérese da massa tumoral, que se apresentava difusamente aderida à pleura parietal em toda a sua extensäo e que invadia o lobo inferior do pulmäo direito. Após o diagnóstico histopatológico e confirmaçäo laboratorial, a paciente foi encaminhada ao Instituto Nacional de Câncer para iniciar tratamento com quimioterapia combinada
Subject(s)
Humans , Female , Adult , Pregnancy , Choriocarcinoma/diagnosis , Pleural Neoplasms/secondary , Pleura/pathology , Thoracotomy , Trophoblastic Neoplasms , Uterine Neoplasms/pathology , Hepatomegaly , Hydatidiform Mole , Immunohistochemistry , Lung Neoplasms/secondary , Menorrhagia , Trophoblastic Neoplasms/diagnosis , Oligomenorrhea , Radiography, Thoracic , Thoracoscopy , Tomography, X-Ray ComputedABSTRACT
This retrospective study included 20 patients with malignant pleural effusion [MPEs], from breast and bronchogenic carcinoma who attended at NEMROCK over one-year period [1995-1996]. All patients underwent simple aspiration followed by intrapleural instillation of 60 mg bleomycine dissolved in 100 ml saline that would be repeated 2-3 times. The overall response rate was 70%. 60% had complete remission, no response was observed in 30% of the cases. The procedure is convenient and safe with low toxicity, requiring no hospitalization and can be given to immunocompromised patients and those who are under systemic chemotherapy
Subject(s)
Humans , Male , Female , Bleomycin , Pleural Effusion/drug therapy , Neoplasms/therapy , Pleural Neoplasms/secondary , Pleura/pathology , Pleural Effusion/prevention & controlABSTRACT
Se revisaron 75 casos de pacientes con derrame pleural que consultaron al HURGV entre el 15 de mayo de 1986 y el 15 de noviembre de 1987 y a quienes se les practico citologia de liquido pleural y biopsia pleural. Se estudian las principales causas de efusion pleural en nuestro medio y especificamente las producidas por lesiones tumorales maligans metastasicas a pleura. Se mide la sensibilidad, la especificidad, el valor predictivo postiivo y el valor predictivo negativo de todos los metodos dianosticos arriba enunciados en la deteccion de dichos procesos neoplasicos y se comparan sus resultados
Subject(s)
Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Adult , Aged , Humans , Male , Female , Pleural Effusion , Pleural Neoplasms , Colombia , Pleural Effusion/epidemiology , Pleural Effusion/pathology , Pleural Neoplasms/complications , Pleural Neoplasms/pathology , Pleural Neoplasms/secondaryABSTRACT
Presentamos un caso de epitelioma o carcinoma basocelular metatípico recaída con metástasis regionales ganglionares y cutáneas y a distancia cutánea y pleuropulmonares. Estas últimas fueron la causa de muerte, a los 3 años de su detección por radiografías y tomografías. La histopatología con microscópio óptico de una de las metástasis cutáneas correspondió a un carcinoma basocelular cordonado y lobulado, con sectores metatípicos, queratósicos y adenoides. El motivo del presente trabajo fue el estudio ultraestructural de esta metástasis, que mostró células pequeñas de núcleo irregular, nucléolos de distinto tamaño, desmosomas poco desarrollados, escaso citoplasma con esbozo de material disqueratósico y ausencia de tonofilamentos
Subject(s)
Middle Aged , Humans , Male , Carcinoma, Basal Cell/ultrastructure , Lung Neoplasms/ultrastructure , Neoplasm Metastasis/ultrastructure , Pleural Neoplasms/ultrastructure , Skin Neoplasms/ultrastructure , Lung Neoplasms/secondary , Pleural Neoplasms/secondary , Recurrence , Skin Neoplasms/secondaryABSTRACT
Se estudiaron en forma prospectiva 32 pacientes con diagnóstico de derrame pleural y en quienes se llegó a una conclusión diagnósticada con el estudio anatomopatológico de la pleura obtenida con aguja de Cope. Se correlacionaron los hallazgos anatómicos con las características citoquímicas, inmunológicas y bacteriológicas del líquido, para obtener un posible patrón citoquímico que pudiese ayudar al diagnóstico cuando no se dispone de la biopsia pleural. En el estudio, 14(43.7%) pacientes tuvieron tuberculosis (TBC) pleural, 6(18.7%) carcinoma (CA) metastásico a pleura y en 12(37.5%) no se obtuvo una conclusión anatomopatológica. El trabajo muestra que la biopsia pleural y el cultivo del líquido son los exámenes de mayor especificidad diagnóstica. Los otros exámenes citoquímicos no son específicos en el diagnóstico etiológico pero ayudan en la diferenciación entre exudado y trasudado