ABSTRACT
Plumbagin is a naturally occurring naphthoquinone isolated from roots of Plumbago scandens. The plant was collected at the Campus of Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. P. scandens is used as a traditional medicine for the treatment of several diseases. The antimicrobial activity of plumbagin was evaluated using the macrodilution method. The compound exhibited relatively specific activity against bacteria and yeast. The minimum inhibitory concentration test showed the growth inhibiton of Staphylococcus aureus at a concentration of 1.56 æg/ml and of Candida albicans at a concentration of 0.78 æg/ml. These results suggest the naphthoquinone plumbagin as a promising antimicrobial agent.
Subject(s)
Anti-Infective Agents , Candida albicans , Escherichia coli , Plumbago litteralis , Salmonella typhimurium , Staphylococcus aureus , Microbial Sensitivity Tests , Plant ExtractsABSTRACT
La plumbagina utilizada en la experiencia fue aislada de la Pera benesis (EUPHORBIACEAE), compuesto que ha revelado presentar actividad antibacteriana, antimicótica, pesticida y contra la leishmaniasis. Los resultadosobtenidos de DL-50 a través del Método de Reed Muench y Spearman Karber fueron de 7,9 y 6,15 mg/Kg de peso corporal respectivamente, y 4,94 a 7,65 como límites de confianza, reportándose a la plumbagina como un compuesto tóxico