ABSTRACT
Abstract Porokeratosis represents a group of disorders of epidermal keratinization that are characterized by one or more annular plaques surrounded by a histologically distinctive hyperkeratotic ridge-like border called the cornoid lamella. Many studies showed that organ transplantation and immunosuppression were associated in a significant number of cases. Furthermore, an association with squamous cell carcinoma and basal cell carcinoma has been noted in all variants of porokeratosis. The rarity of this disorder and its atypical clinical presentation – a single lesion on the thumb of an HIV-positive male patient – motivated this report.
Subject(s)
Humans , Male , Adult , HIV Infections/complications , HIV Infections/pathology , Porokeratosis/pathology , Porokeratosis/virology , Immunocompetence , Skin Transplantation , Treatment Outcome , Porokeratosis/surgery , Epidermis/pathologyABSTRACT
Las poroqueratosis son enfermedades genéticamente determinadas, definidas como desórdenes específicos de la queratinización. Se han clasificado en cinco grandes variantes clínicas: la poroqueratosis actínica superficial diseminada, la poroqueratosis clásica de Mibelli, la poroqueratosis palmoplantar diseminada, la poroqueratosis lineal y la poroqueratosis punctata, caracterizadas histológicamente por la presencia de la lámina cornoide, una columna paraqueratósica densa, bien delimitada del resto de los corneocitos. Todas las formas de presentación tienen riesgo de transformación neoplásica. Los pacientes con poroqueratosis deben fotoprotegerse adecuadamente y evitar la exposición solar excesiva y deben tener un control dermatológico periódico para pesquisar precozmente lesiones neoplásicas.