ABSTRACT
El penfigoide gestacional es una dermatosis rara, que se presenta durante el embarazo. Se caracteriza por una respuesta autoinmune contra las proteínas de los hemidesmosomas, que genera un clivaje entre la epidermis y la dermis tanto de la piel como de las mucosas. Clínicamente, presenta prurito intenso, placas y pápulas eritematosas, que evolucionan a apollas con distribución en el abdomen y los miembros. Como complicaciones, en el feto puede generar parto prematuro y bajo peso para la edad gestacional, con alto riesgo de mortalidad. (AU)
Gestational pemphygoid is a rare, autoimmune dermatosis that occurs during pregnancy. It is characterized by an autoimmune response against hemidesmosome proteins, generating a cleavage between the epidermis and the dermis in the skin and mucous membranes. Clinically it presents with intense pruritus, plaques and erythematous papules that evolve to blisters that are distributed mainly in the abdomen and limbs. The complications are preterm birth and low weight for gestational age, with high risk of mortality. (AU)
Subject(s)
Humans , Male , Female , Pregnancy , Infant, Newborn , Adult , Pemphigoid Gestationis/diagnosis , Pemphigoid, Bullous/diagnosis , Prednisone/analogs & derivatives , Pemphigoid Gestationis/drug therapy , Pemphigoid, Bullous/etiology , Pemphigoid, Bullous/drug therapy , Diabetes, Gestational/diagnosis , Glucocorticoids/therapeutic useABSTRACT
Behçet disease is an idiopathic, multisystem disorder characterized by recurrent episodes of orogenital ulceration and vasculitis of the veins and arteries of all calibers. Ocular involvement may affect the conjunctiva, sclera, uveal tract, vitreous, blood vessels, and retina. Many theories have pointed toward an autoimmune response behind its pathogenesis, which may be triggered by exposure to an infectious agent. Frosted branch angiitis is characterized by vascular inflammation, sheathing, retinal edema, and retinal hemorrhages. The disease may be idiopathic in a majority of the cases or may be associated with ocular and systemic pathology. Association between Behηet disease, Frosted branch angiitis, and neuroretinitis is not reported in literature. This uncommon combination reflects the varied systemic and ocular manifestations in Behηet disease, especially in patients who are not diagnosed and treated in time. We hereby report a case of bilateral frosted branch angiitis and neuroretinitis in a young male from Middle-east, suffering from Behçet disease.
Subject(s)
Adult , Antirheumatic Agents/administration & dosage , Behcet Syndrome/complications , Behcet Syndrome/diagnosis , Behcet Syndrome/drug therapy , Colchicine/administration & dosage , Drug Administration Schedule , Fundus Oculi , Humans , Injections, Intravenous , Magnetic Resonance Imaging , Male , Prednisone/administration & dosage , Prednisone/analogs & derivatives , Retinal Hemorrhage/diagnosis , Retinal Hemorrhage/etiology , Retinitis/diagnosis , Retinitis/etiology , Silymarin/administration & dosage , Vasculitis/diagnosis , Vasculitis/etiology , Vasculitis/pathologySubject(s)
Aged , Female , Humans , Male , Middle Aged , Young Adult , Anti-Inflammatory Agents/therapeutic use , Immunosuppressive Agents/therapeutic use , IgA Vasculitis/drug therapy , IgA Vasculitis/pathology , Skin/pathology , Biopsy , Cyclophosphamide/therapeutic use , Immunoglobulin A/blood , Immunoglobulin G/blood , Methylprednisolone/therapeutic use , Prednisone/analogs & derivatives , Prednisone/therapeutic use , Young AdultSubject(s)
Humans , Male , Female , Adult , Myositis/diagnosis , Autoantibodies/blood , Biopsy , Creatine Kinase/metabolism , Dermatomyositis/diagnosis , Methotrexate/therapeutic use , Myositis/classification , Myositis/physiopathology , Polymyositis/diagnosis , Prednisone/analogs & derivatives , Serologic TestsABSTRACT
Se presenta una síntesis del estudio multicéntrico de tratamiento de la neuritis óptica efectuado en varios centros de los Estados Unidos de Norteamérica. Se presentan las características clínicas de la neuritis óptica de este grupo de pacientes. Además se informa de los hallazgos neurológicos en el examen inicial, la incidencia de esclerosis múltiple, los hallazgos de la resonancia magnética cerebral y finalmente el valor terapéutico de los corticoides